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Profiling and identification of chemical components of shenshao tablet and its absorbed components in rats by comprehensive HPLC/DAD/ESI-MS^n analysis

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Chinese Journal of Natural Medicines 2018年第10期16卷 791-800页

作者： MIAO Wen-Juan HU Ying JIA Li ZHANG Chun-Xia YANG Wen-Zhi ZHANG Ping GUO De-An Department of Pharmacy Institute of Hematology and Blood Disease HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin 300020China Tianjin State Key Laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 300193China State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China

shenshao tablet(SST),prepared from Paeoniae Radix Alba(PRA)and total ginsenoside of Ginseng Stems and Leaves(GSL),is a traditional Chinese medicine(TCM)preparation prescribed to treat coronary heart ***,its chemical composition and the components that can migrate into blood potentially exerting the therapeutic effects have rarely been *** developed an HPLC/DAD/ESI-MS^n approach aiming to comprehensively profile and identify both the chemical components of SST and its absorbed ingredients(and metabolites)in rat plasma and *** separation was performed on an Agilent Eclipse XDB C_(18) column using acetonitrile/0.1% formic acid as the mobile *** detection was conducted in both negative and positive ESI modes to yield more structure *** with reference compounds(t_R,MS^n),interpretation of the fragmentation pathways,and searching of in-house database,were utilized for more reliable structure elucidation.A total of 82 components,including 21monoterpene glycosides,four galloyl glucoses,two phenols from PRA,and 55 ginsenosides from GSL,were identified or tentatively characterized from the 70% ethanolic extract of *** them,seven and 24 prototype compounds could be detectable in the plasma and urine samples,respectively,after oral administration of an SST extract(4 g×kg^(–1))in *** metabolites were observed in the rat *** findings of this work first unveiled the chemical complexity of SST and its absorbed components,which would be beneficial to understanding the therapeutic basis and quality control of SST.

关键词： shenshao tablet Paeoniae Radix Alba Total ginsenoside of Ginseng Stems and Leaves Chemical component

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Effect of shenshao tablet(参芍片) on the Quality of Life for Coronary Heart Disease Patients with Stable Angina Pectoris

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Chinese Journal of Integrative Medicine 2009年第5期15卷 328-332页

作者：王阶何庆勇张允岭 Guang'anmen Hospital China Academy of Chinese Medical Sciences Dongfang Hospital Beijing University of Chinese Medicine

Objective： To observe the effect of Chinese medicine shenshao tablet （参芍片, SST） on the quality of life in coronary heart disease （CHD） patients with stable angina pectoris （SAP）. Methods： Sixty-six patients with SAP confirmed by coronary angiography were enrolled and assigned to two groups by means of PROC PLAN using a SAS 6.12 software in a double-blinded, randomized, placebo-controlled design. Patients in the treated group were treated with SST, and the others in the control group were given placebo. The weekly angina frequency, quality of life scale [Seattle Angina Questionnaire （SAQ）] and incidence of important clinical events were observed to evaluate the intervention effect of SST on the quality of life for CHD patients with SAP. Results： During the study, one case dropped out in the treated group and two cases in the control group, respectively, and 63 cases including 32 cases in the treated group, and 31 cases in the control group completed the trial. After four weeks of treatment, the weekly angina frequency of the treated group （5.32± 2.46 times per week） was significantly less than that of the control group （7.32± 3.20 times per week, P 〈 0.05）. The total score of the quality of life in the treated group （71.30± 5.44） was obviously higher than that in the control group （63.50± 4.60, P 〈 0.01）, and the angina stability, angina frequency, and treatment satisfaction were significantly superior to those in the control group （P〈 0.01）. The incidence of important clinical events of the treated group （3.1%） was lower than that of the control group （6.5%） during the six-month follow-up period, but the difference was insignificant （P 〉 0.05）. Conclusion： SST could lower the angina frequency and greatly improve the quality of life in CHD patients with SAP.

关键词： shenshao tablet stable angina pectoris Seattle Angina Questionnaire important clinical events

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