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Mechanism of shengmai injection on Anti-Sepsis and Protective Activities of Intestinal Mucosal Barrier in Mice

Chinese Journal of Integrative Medicine 2022年第9期28卷 817-822页

作者： LU Juan YU Yue WANG Xiao-jing CHAI Rui-ping LYU Xin-kai DENG Ming-hui HU Mei-geng QI Yun CHEN Xi Institute of Medicinal Plant Development Chinese Academy of Medical SciencesPeking Union Medical CollegeBeijing100193China

Objective:To study the mechanism of shengmai injection(SMI)on anti-sepsis and protective activities of intestinal mucosal barrier.Methods:The contents of 11 active components of SMI including ginsenoside Rb1,Rb2,Rb3,Rd,Re,Rf,Rg1,Rg2,ophioposide D,schisandrol A and schisantherin A were determined using ultra-performance liquid chromatography.Fifty mice were randomly divided into the blank,the model,the low-,medium-and high-dose SMI groups(0.375,0.75,1.5 mL/kg,respectively)by random number table,10 mice in each group.On SMI group,SMI was administrated to mice daily via tail vein injection for 3 consecutive days,while the mice in the blank and model groups were given 0.1 mL of normal saline.One hour after the last SMI administration,except the blank group,the mice in other groups were intraperitoneally injected with lipopolysaccharide(LPS)saline solution(2 mL/kg)at a dosage of 5 mL/kg for development of endotoxemia mice model.The mice in the blank group were given the same volume of normal saline.Inflammatory factors including interferon-γ(INF-γ),tumor necrosis factor-α(TNF-α),interleukin(IL)-2 and IL-10 were measured by flow cytometry.Myosin light-chain kinase(MLCK),nuclear factorκB(NF-κB)levels,and change of Occludin proteins in jejunum samples were analyzed by Western blot.Results:The decreasing trends of INF-γ,TNF-α and IL-2 were found in serum of SMI treatment groups.In SMI-treated mice,the content of Occludin increased and MLCK protein decreased compared with the model group(P0.05).Conclusion:SMI may exert its anti-sepsis activity mainly through NF-κB-pro-inflammatory factor-MLCK-TJ cascade.

关键词： shengmai injection sepsis intestinal mucosal barrier mechanism Chinese medicine

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Effect of shengmai injection(生脉注射液) on Diaphragmatic Contractility in Doxorubicin-Treated Rats

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Chinese Journal of Integrative Medicine 2014年第1期20卷 43-48页

作者：葛敏方迎艳刘国平关宿东 Department of Physiology Bengbu Medical College

Objective：To explore the diaphragmatic toxicity in doxorubicin（DOX）-treated rats and the related mechanisms,as well as the effects of shengmai injection（SMI,生脉注射液）on the diaphragmatic dysfunction.Methods：Thirty Sprague-Dawley male rats were randomly divided into three groups：control,DOX-treated and DOX＋SMI treated groups.DOX was given to rats in DOX and DOX＋SMI groups in 6 equal doses[2.5 mg/kg,intraperitoneal injection（i.p.）],on alternate days,over a period of 2 weeks for a cumulative dose of 15 mg/kg.SMI was given to DOX＋SMI rats in 12 doses（3 mL/kg,i.p.）for a period of 2 weeks before the administration of DOX and 2 weeks during the administration of DOX.The rats in the control group received equal volume of normal saline.Subsequently,the twitch and tetanic characteristics and force-frequency relationships,and the malondialdehyde（MDA）levels and the superoxide dismutase（SOD）activities,as well as the mRNA content and proteins of inducible nitric oxide synthase（iNOS）were determined.Results：The DOX-treated rats had decreased the peak twitch tension（Pt）,maximal tetanic tension（P0）and force-frequency relationship as compared with the control rats（P〈0.01）,while the diaphragm contractility in rats treated with SMI were significantly higher than that in DOX-treated rats（P〈0.01）.The DOX-treated rats had increased MAD levels and decreased SOD activities（P〈0.05）,and SMI decreased the MDA levels and increased the SOD activities in DOX-treated rats（P〈0.05）.Ultrastructure of diaphragm in the DOX-treated rats revealed typical alterations including fracture of diaphragm fibers,and edema and degeneration of mitochondria;these changes were relieved by SMI treatment.The mRNA content and protein of iNOS in DOX-treated rats were remarkably higher than those in control rats（P〈0.01）,while SMI decreased the mRNA expression level of iNOS in DOX-treated rats（P〈0.05）.Conclusions：Lipid peroxidation is responsible for DOX-induced diaphragm toxicity.SMI protects diaphragm muscles and their function from DOX impairment,and these beneficial ef

关键词： shengmai injection doxorubicin diaphragm lipid peroxidation nitric oxide

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Effect of shengmai injection(生脉注射液) on Cardiac Function and Inflammatory Reaction in Patients with Acute Coronary Syndrome

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Chinese Journal of Integrative Medicine 2008年第4期14卷 107-110页

作者：张亚臣陈瑞明吕宝经荣烨之 Department of Internal Cardiology Xinhua Hospital Affiliated to Shanghai Jiaotong Medical University School of Medicine Department of Laboratory Ruijin Hospital Shanghai Jiaotong University School of Medicine

Objective： To confirm the effect of shengmai injection （生脉注射液, SMI） in improving cardiac function in patients with acute coronary syndrome （ACS） and to explore its influence on inflammatory reaction in patients. Methods： Ninety ACS patients were randomized into two groups, the control group treated with conventional therapy and the SMI group treated with SMI. The patients＇ cardiac function was noted and the content of high sensitive C-reactive protein （hs-CRP） in venous blood was measured before treatment and 1 week and 3 weeks after treatment, so as to observe and compare their changes between the two groups. Results： The cardiac output, stroke volume and ejection fraction in the SMI group after 3 weeks of treatment were all higher than those in the control group （P〈0.05）. The serum content of hs-CRP was reduced in both groups （P〈0.05）, but the reduction in the SMI group was more significant than that in the control group （P〈0.05）. Conclusion： SMI could improve the cardiac function and further inhibit the inflammatory reaction in patients with ACS.

关键词： shengmai injection acute coronary syndrome C-reactive protein inflammatory reaction cardiac function

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Protective Effect of shengmai injection on Rats with Contrast Medium-Associated Acute Renal Failure

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Chinese Journal of Integrative Medicine 1998年第4期4卷 290-292页

作者：段绍斌罗季安刘瑞洪徐锡萍

Objective: Radiographic contrast media can induce renal failure and it may serve as an experimental model of acute renal failure (ARF). The study was aimed to determine the protective effect of shengmai injection (SMI) on contrast medium-associated ARF in Sprague-Dawley (SD) rats. Methods: Twenty healthy SD rats of both sex were randomly divided into two groups, Group A (control group) treated with glycerin + 0.9 % saline + meglucamine diatrizoate, and group B (preventive group) with glycerin + SMI + meglucamine diatrizoate. Results: In Group B, the levels of blood urea nitrogen, serum creatinine, renal phospholipase A2 (PLA2) and calcium were all significantly lower than those in Group A, P < 0. 01. The results indicated the renal injury induced by meglucamine diatrizoate was alleviated by SMI. Conclusion: SMI could prevent renal tissue from contrast media induced nephropathy in SD rats. The effect may partially owe to its preventing intracellular calcium accumulation, inhibiting PLA2 activity and dilating renal vessels.

关键词： nephrotoxicity contrast media shengmai injection renal failure meglucamine diatrizoate

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The rapeutic Effect of Sheng mai injection (生脉注射液) on Respiratory Functionin Chronic Obstructive Pulmonary Disease

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Chinese Journal of Integrative Medicine 2000年第2期6卷 101-103页

作者：方宗君王丽华

Objective: To explore the therapeutic effect of shengmai injec tion (SMI) on respiratory function in chronic obstructive pulmonary disease (COPD ).Methods: Twenty patients with COPD were continuously treated w ith SMI by intravenous drip for 14 days and their lung vital capacity (VC),for ced vital capacity (FVC),forced vital capacity of the first second (FEV1),FEV1/FVC , maximum voluntary ventilation (MVV), maximum inspiratory pressure (MIP),load respiratory time (LT), 6 minute walk distance (6 MWD), arterial blood gas an alysis, and Borg dyspnea scale were examined respectively before and after treatment a nd compared before and after treatment or with the control group.Results: After treatment all parameters in the treated group were significantly better than those in the control group or than those before treatment (Pinjection in treating COPD

关键词： shengmai injection chronic obstructiv e pulmonary disease respiratory function

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