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The developmental changes in intestinal epithelial cell proliferation,differentiation,and shedding in weaning piglets

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Animal Nutrition 2022年第2期9卷 214-222页

作者： Min Wang Lixia Wang Xian Tan Lei Wang Xia Xiong Yancan Wang Qiye Wang Huansheng Yang Yulong Yin Hunan International Joint Laboratory of Animal Intestinal Ecology and Health Laboratory of Animal Nutrition and Human HealthCollege of Life SciencesHunan Normal UniversityChangsha 410081HunanChina Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry ProductionKey Laboratory of Agro-ecological Processes in Subtropical RegionInstitute of Subtropical AgricultureChinese Academy of SciencesChangsha 410125HunanChina

Intestinal epithelial homeostasis plays an important role in intestinal morphology and function.However,the developmental changes in intestinal epithelial cell turnover in piglets during early weaning are unknown so far.Thus,the aim of this work was to detect changes in piglet gut development from weaning to post-weaning d 14.Accordingly,40 piglets were used in the present study,and 8 piglets were randomly selected for sampling at d 0,1,3,7 and 14 post-weaning,respectively.The results showed that weaning stress significantly affected small intestinal morphological architecture,and this impact was the worst on d 3,and then returned to normal on d 14.Furthermore,the number of the marker of proliferation Ki-67(Ki67)positive cells was decreased on d 1 and 3,and then recovered on d 14(Pshedding on d 1 to 7 compared on d 0(Pshedding,and the mTOR signaling pathway was involved in this process.Our findings provide a cellular mechanism for intestinal developmental changes during weaning periods.This may provide nutritionists with better insight into designing efficient in-feed alternatives for preventing the unfavorable gut development in weaning piglets.

关键词： Intestinal epithelial cell Proliferation Differentiation shedding Weaning piglet

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Analysis of oil shedding and ligaments formation on bearing rotary elements

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Chinese Journal of Aeronautics 2023年第2期36卷 377-387页

作者： Donglei ZHU Guoding CHEN Yanjun LI Chaoyang ZHANG Lin WANG School of Mechanical Engineering Northwestern Polytechnical UniversityXi'an 710072China China Gas Turbine Establishment Chengdu 610500China

For designing efficient lubrication system of an aeroengine bearing chamber,sufficient knowledge on oil/air two-phase flow characteristics is required.When analyzing bearing chamber two-phase flow,the essential prerequisite is quantifying the oil ligaments,which are detached from bearing rotary elements and shed into the bearing chamber.Related investigations are mainly targeted at liquid shedding on the rotating disk as opposed to the bearing rotary elements.Moreover,the research based on bearing rotary elements is conducted by experiment.Due to the limited operating conditions,experimental studies cannot guide engineering applications.To overcome these limitations,a theoretical model is established in this paper,for revealing the mechanism of oil shedding from bearing rotary elements and quantifying the shedding ligaments.The theoretical model is validated against experimental results from classical studies.In addition,the correlation for shedding ligaments number based on aeroengine bearing structural and operational parameters is obtained via theoretical analysis.The analytical results demonstrate that oil shedding and ligaments formation appear at the edge of bearing inner race outer-periphery.The number of shedding ligaments increases with the rise of shaft rotational speed while decreases with the growth of oil viscosity.

关键词： Aeroengine bearing chamber Ligaments Lubrication Mechanical analysis shedding Wave

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Modeling ash deposition and shedding during oxy-combustion of coal/rice husk blends at 70%inlet O_(2)

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International Journal of Coal Science & Technology 2023年第2期10卷 196-209页

作者： Gautham Krishnamoorthy Department of Chemical Engineering UPSON Ⅱ Room 365241 Centennial DriveUniversity of North DakotaGrand ForksND 58202-7101USA

Co-firing rice husk(RH)and coal with carbon capture using oxy-combustion presents a net carbon negative energy produc-tion opportunity.In addition,the high fusion temperature of the non-sticky,silica rich,RH can mitigate ash deposition as well as promote shedding of deposits.To identify the optimum operating conditions,fuel particle sizes,and blend ratios that minimize ash deposition,a Computational Fluid Dynamic methodology with add-on ash deposition and shedding models were employed to predict outer ash deposition and shedding rates during co-combustion of coal/RH in AIR and O2/CO_(2)(70/30 vol%,OXY70)oxidizer compositions.After ensuring that the fly-ash particle size distributions and particle Stokes numbers near the deposition surface were accurately represented(to model impaction),appropriate models for coal ash and RH ash viscosities that were accurate in the temperature region(1200-1300 K)of interest in this study were identified.A particle viscosity and kinetic energy(PKE)based capture criterion was enforced to model the ash capture.An erosion/shed-ding criterion that takes the deposit melt fraction and the energy consumed during particle impact into account was also implemented.Deposition rate predictions as well as the deposition rate enhancement(OXY70/AIR)were in good agreement with measured values.While the OXY70 scenario was associated with a significant reduction(60%-70%)in flue gas velocities,it also resulted in larger fly-ash particles.As a result,the PKE distributions of the erosive RH ash were similar in both scenarios and resulted in similar shedding rates.

关键词： CFD Oxy-Combustion Ash Deposition shedding Co-firing

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An unusual COVID-19 case with over four months of viral shedding in the presence of low neutralizing antibodies: a case report

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The Journal of Biomedical Research 2020年第6期34卷 470-474页

作者： Wei Chen Zhiliang Hu Changhua Yi Yun Chi Qingfang Xiong Chee Wah Tan Yongxiang Yi Lin-Fa Wang Clinical Research Center the Second Hospital of NanjingNanjing University of Chinese MedicineNanjingJiangsu 210003China Nanjing infectious Disease Center the Second Hospital of NanjingNanjing University of Chinese MedicineNanjingJiangsu 210003China Center for Global Health School of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Programme in Emerging Infectious Diseases Duke-NUS Medical SchoolSingapore 169857Singapore

The ongoing coronavirus disease 2019(COVID-19)pandemic is a global public health crisis,causing social and economic disasters in many countries.In China,two-consecutive negative results of nucleic acid tests for SARS-CoV-2 from the respiratory samples are required to end the quarantine of COVID-19 patients.However,clinicians face a dilemma in case of patients with long-term viral shedding.This report described an unusual COVID-19 case who had persistent viral RNA positivity for more than 4 months after initial illness in the presence of low neutralizing antibodies,but without prolonged clinical symptoms.Multiple anti-viral drug treatments had no impact and there was no evidence of re-infection.When the patient was self-quarantined at home,no infection occurred to the three family members living with her for 15 to 19 days.Sputum viral culture in BSL-3 laboratory on the 102nd day after symptom onset was negative.From the 129th day on,8 continuous nucleic acid tests of sputum samples showed negative results.The patient was discharged on 137th days since symptom onset.In conclusion,viral RNA shedding in the sputum of the COVID-19 patient may last over 4 months.As no evidence shows the existence of infectious virus,two-consecutive negative nucleic acid tests may not be the prerequisite for ending quarantine of COVID-19 patients with prolonged viral shedding.

关键词： COVID-19 SARS-CoV-2 viral shedding neutralizing antibodies quarantine

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Ordered and chaotic phenomena of vortex shedding in an excited wake flow behind a 2-D oscillating circular cylinder

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Science China Mathematics 1995年第4期38卷 447-461页

作者：魏中磊张子强 H.E.Fiedler Department of Mechanics Peking University Beijing 100871 China H-F Institute TU D-10623 Berlin Germany

The behavior of synchronization in an open flow dynamical system, especially in an excited wake flow behind a 2-D oscillating circular cylinder with Reynolds number Re ranging from 45 to 200 is presented. The experiment reveals that only under certain conditions can the competition between frequencies of oscillating cylinder and the vortex shedding in the wake flow result in "window of chaos" with the mixed RTN and Feigenbaum scenario in the range of Re<185.

关键词： synchronization chaotic behavior wake vortex shedding oscillation.

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Load shedding Strategy Based on Combined Feed-Forward Plus Feedback Control over Data Streams

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Journal of Beijing Institute of Technology 2019年第3期28卷 437-446页

作者： Donghong Han Yi Fang Daqing Yi Yifei Zhang Xiang Tang Guoren Wang School of Computer Science and Engineering Northeastern UniversityShenyang 100819LiaoningChina School of Computer Science Carnegie Mellon UniversityPittsburghPAUSA

In data stream management systems (DSMSs), how to maintain the quality of queries is a difficult problem because both the processing cost and data arrival rates are highly unpredictable. When the system is overloaded, quality degrades significantly and thus load shedding becomes necessary. Unlike processing overloading in the general way which is only by a feedback control (FB) loop to obtain a good and stable performance over data streams, a feedback plus feed-forward control (FFC) strategy is introduced in DSMSs, which have a good quality of service (QoS) in the aspects of miss ratio and processing delay. In this paper, a quality adaptation framework is proposed, in which the control-theory-based techniques are leveraged to adjust the application behavior with the considerations of the current system status. Compared to previous solutions, the FFC strategy achieves a good quality with a waste of fewer resources.

关键词： data stream management systems (DSMSs) load shedding feedback control feed-forward control quality of service (QoS)

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EXPERIMENTAL INVESTIGATION ON ORDERED AND CHAOTIC PHENOMENA OF VORTEX shedding IN THE WAKE FLOW BEHIND A TWO-DIMENSIONAL CIRCULAR CYLINDER

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Science China Mathematics 1992年第1期35卷 81-90页

作者：魏中磊吴忠 H.E.FIEDLER Department of Mechnics Peking University Beijing 100871 PRC Hermann-Fottinger Institut Technische Universitat Berlin 1000 Berlin 12

In this paper, some preliminary experiments of ordered and chaotic vortex sheddingsbehind a 2--D circular cylinder at Reynolds numbers ranging from R_e=50 to 400 are presented.A transition in vortex shedding from the laminar to chaotic state occurs at Re=184.6-193.5,but it is seemingly not through the quasi--periodicity routes. There is a couple of dis-continuities in slope on the curve of the relationship between the vortex shedding frequencyand Reynolds number. The discontinuity at Re = 70 might correspond to the change of themode of the oblique vortex shedding. The second one at Re = 193.5 is responsible for thetransition from the ordered to the chaotic state.

关键词： ordered and chaotic phenomena vortex shedding wake.

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Analysis and Design of Conjugate Cam shedding Mechanism with Dual Driving Shafts

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Journal of China Textile University(English Edition) 1998年第1期15卷 57-60页

作者：蒋秀明 Tianjin Inst of Textile Science and Technology Tianjin China

The principle of conjugate cam shedding mechanism forthe outside tappets with dual driving shafts is discussed,and its design conditions and parameters are studied,giving the results of practical calculations finally.

关键词： conjugate cam dual driving shedding mechanism

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Inhibitory role of TACE/ADAM17 cytotail in protein ectodomain shedding

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World Journal of Biological Chemistry 2011年第11期2卷 246-251页

作者： Liliana Pérez Department of Physiology and Biophysics Robert Wood Johnson Medical School University of Medicine and Dentistry of New Jersey

AIM:To determine if the cytotail of the principal sheddase tumor necrosis factor-α converting enzyme (TACE;ADAM17) controls protein ectodomain shedding.METHODS:Site-directed mutagenesis was performed to derive TACE variants. The resulting TACE expression plasmids with amino acid substitutions in the extracel-lular,cysteine-rich disintegrin domain (CRD) and/or deleted cytotail,along with an expression vector for the enhanced green fluorescence protein were transfected into shedding-defective M1 mutants stably expressing transmembrane L-selectin or transforming growth factor (TGF)-α. The expression levels of the TACE substrates at the cell surface were determined by flow cytometry. RESULTS:Consistent with published data,a single point mutation (C600Y) in the CRD led to shedding defi-ciency. However,removal of the cytotail from the C600Y TACE variant partially restored ectodomain cleavage of TGF-α and L-selectin. Cytotail-deleted mutants with any other substituting amino acid residues in place of Cys600 displayed similar function compared with tail-less C600Y TACE.CONCLUSION:The cytotail plays an inhibitory role,which becomes evident when it is removed from an enzyme with another mutation that affects the enzyme function.

关键词： ADAM17 Ectodomain shedding L-selectin Tumor necrosis factor-α converting enzyme

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Utilizing Stability Index Tracing for Precise Load Buses Identification in Load shedding Problem

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Engineering（科研） 2013年第1期5卷 168-173页

作者： Z. Hamid I. Musirin M. M. Othman Faculty of Electrical Engineering Universiti Teknologi MARA Selangor Malaysia

This paper proposes a new approach for suitable load buses identification via stability index tracing in performing corrective load shedding. The proposed identification technique is called the Fast Voltage Stability Index Load Tracing (FVSI-LT). By implementing a power tracing algorithm, a group of major contributors on the stress experienced by a power system is able to be precisely identified by a system operator (SO) based on the traced values of FVSI. To be precise, the traced FVSI via FVSI-LT can be used to form a ranking list indicating the priority of buses committed for shedding purpose. After designing a Fuzzy Inference System (FIS) for deciding the allowable load powers to be shed and performing experiment on IEEE 57-Bus reliability test system (RTS), it is revealed that the ranking list provided by FVSI-LT results to the most consistent improvement in terms of voltage stability and losses minimization.

关键词： fuzzy logic FVSI-LT load shedding stability index tracing

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