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Biomimetic nanoparticles drive the mechanism understanding of shear-wave elasticity stiffness in triple negative breast cancers to predict clinical treatment

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Bioactive Materials 2023年第4期22卷 567-587页

作者： Dongdong Zheng Jin Zhou Lang Qian XueJiao Liu Cai Chang Shuang Tang Hongbo Zhang Shichong Zhou Department of Ultrasound Fudan University Shanghai Cancer CenterShanghai200032PR China Pharmaceutical Sciences Laboratory Åbo Akademi UniversityFI-00520TurkuFinland Cancer Institute Fudan University Shanghai Cancer CenterShanghai200032PR China Institutes of Biomedical Sciences and Department of Chemistry Fudan UniversityShanghai200032PR China Department of Nuclear Medicine Fudan University Shanghai Cancer CenterShanghai200032PR China Turku Bioscience Center University of Turku andÅbo Akademi UniversityFI-00520TurkuFinland The First Affiliated Hospital of Wenzhou Medical University Wenzhou325000PR China

In clinical practice,we noticed that triple negative breast cancer(TNBC)patients had higher shear-wave elasticity(SWE)stiffness than non-TNBC patients and a higherα-SMA expression was found in TNBC tissues than the non-TNBC ***,SWE stiffness also shows a clear correlation to neoadjuvant response *** elaborate this phenomenon,TNBC cell membrane-modified polylactide acid-glycolic acid(PLGA)nanoparticle was fabricated to specifically deliver artesunate to regulate SWE stiffness through inhibiting CAFs functional *** tested in MDA-MB-231 and E0771 orthotopic tumor models,CAFs functional status inhibited by 231M-ARS@PLGA nanoparticles(231M-AP NPs)had reduced the SWE stiffness as well as attenuated hypoxia of tumor as tumor soil loosening agent which amplified the antitumor effects of paclitaxel and PD1 ***-cell sequencing indicated that the two main CAFs(extracellular matrix and wound healing CAFs)that produces extracellular matrix could influence the tumor SWE stiffness as well as the antitumor effect of ***,biomimetic nanoparticles inhibited CAFs function could attenuate tumor hypoxia by increasing proportion of inflammatory blood vessels and oxygen transport ***,our finding is fundamental for understanding the role of CAFs on affecting SWE stiffness and drugs antitumor effects,which can be further implied in the potential clinical theranostic predicting in neoadjuvant therapy efficacy through non-invasive analyzing of SWE imaging.

关键词： Cancer-associated fibroblasts Biomimetic nanoparticles shear-wave elasticity imaging Theranostic prediction

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