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sex hormones in the modulation of irritable bowel syndrome

World Journal of Gastroenterology 2014年第10期20卷 2433-2448页

作者： Agata Mulak Yvette Taché Muriel Larauche Department of Gastroenterology and Hepatology Wroclaw Medical University 50-556 Wroclaw Poland CURE:Digestive Diseases Research Center and Oppenheimer Family Center for Neurobiology of Stress Digestive Diseases Division Department of MedicineUniversity of California Los Angeles VA Greater Los Angeles Healthcare System Los Angeles CA 90073 United States

Compelling evidence indicates sex and gender differences in epidemiology, symptomatology, pathophysiology, and treatment outcome in irritable bowel syndrome (IBS). Based on the female predominance as well as the correlation between IBS symptoms and hormonal status, several models have been proposed to examine the role of sex hormones in gastrointestinal (GI) function including differences in GI symptoms expression in distinct phases of the menstrual cycle, in pre- and post-menopausal women, during pregnancy, hormonal treatment or after oophorectomy. sex hormones may influence peripheral and central regulatory mechanisms of the brain-gut axis involved in the pathophysiology of IBS contributing to the alterations in visceral sensitivity, motility, intestinal barrier function, and immune activation of intestinal mucosa. sex differences in stress response of the hypothalamic-pituitary-adrenal axis and autonomic nervous system, neuroimmune interactions triggered by stress, as well as estrogen interactions with serotonin and corticotropin-releasing factor signaling systems are being increasingly recognized. A concept of “microgenderome” related to the potential role of sex hormone modulation of the gut microbiota is also emerging. Significant differences between IBS female and male patients regarding symptomatology and comorbidity with other chronic pain syndromes and psychiatric disorders, together with differences in efficacy of serotonergic medications in IBS patients confirm the necessity for more sex-tailored therapeutic approach in this disorder.

关键词： Brain-gut axis Irritable bowel syndrome Microbiota Pain modulation sex hormones

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A possible relationship between serum sex hormones and benign prostatic hyperplasia/Iower urinary tract symptoms in men who underwent transurethral prostate resection

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Asian Journal of Andrology 2017年第2期19卷 230-233页

作者： Yu Wu Hong Pan Wei-Ming Wang Ding Xu Liang Zhang Zheng-Qin Gu Qiang Bai un Qi e-Feng Huang Department of Urology Xinhua Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200092 China Department of Gynecology Xinhua Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200092 China Department of Assisted Reproduction Medicine International Peace Maternity and Child Health Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200030 China

In this study, we examined the relationship between sex hormone levels and lower urinary tract symptoms （LUTS） in men with benign prostatic hyperplasia （BPH） who underwent transurethral surgery. The study was conducted in 158 patients who came to our hospital for surgery. Clinical conditions were assessed by body mass index （BMI）, digital rectal examination, International Prostate Symptom Score （IPSS） and transrectal ultrasound （TRUS）. The levels of sex hormones （including total testosterone （TT）, estradiol （E2）, progesterone （P）, luteinizing hormone （LH）, follicle-stimulating hormone （FSH） and prolactin （PRL）） and prostate-specific antigen （PSA） were reviewed. Correlations were determined through statistical analysis. The mean age was 72.06 _＋ 8.68 years. The total IPSS was significantly associated with the TT level （r = -0.21, P = 0.01）. Other sex hormone levels were not correlated with total IPSS. However, some ratios such as E2/TT （r = 0.23, P = 0o00） and FSH/LH （r = -0.17, P = 0.04） were associated with total IPSS. Further analysis showed that the nocturia was associated with age （r = 0.16, P = 0.04）, BMI （r = 0.21, P = 0.01）, and TT （r = -0.19, P = 0.02）. Moreover, we divided the patients into two subgroups based on IPSS severity （〈20 or 〉20）. The mean TT level was in the normal range, but it was significantly related to the presence of severe LUTS. In summary, our study has shown that the severity of LUTS is associated with TT, EJTT and FSH/LH in men who underwent prostate surgery. Increasing nocturia was observed in lower testosterone patients. Additional larger studies are needed to elucidate the potential mechanisms.

关键词： aging benign prostatic hyperplasia lower urinary tract symptoms sex hormones testosterone

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Role of sex hormones in gastrointestinal motility in pregnant and non-pregnant rats

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World Journal of Gastroenterology 2016年第25期22卷 5761-5768页

作者： Juliana Fernandes Matos Madileine Francely Americo Yuri Karen Sinzato Gustavo Tadeu Volpato Luciana Aparecida Corá Marcos Felipe Freitas Calabresi Ricardo Brandt Oliveira Debora Cristina Damasceno Jose Ricardo Arruda Miranda Sao Paulo State University BotucatuSP 18618-970Brazil Instituto de Ciencias Biologicas e da Saude Federal University of Mato GrossoBarra do GarcasMT 78600-000Brazil Universidade Estadual de Ciencias da Saude de Alagoas MaceioAL 57010-300Brazil Sao Paulo University Ribeirao PretoSP 14049-900Brazil

AIM: To correlate gastric contractility, gastrointestinal transit, and hormone levels in non-pregnant(estrous cycle) and pregnant rats using noninvasive techniques. METHODS: Female rats(n = 23) were randomly divided into(1) non-pregnant,(contractility, n =6; transit, n = 6); and(2) pregnant(contractility, n = 5; transit, n = 6). In each estrous cycle phase or at 0, 7, 14, and 20 d after the confirmation of pregnancy, gastrointestinal transit was recorded by AC biosusceptometry(ACB), and gastric contractility was recorded by ACB and electromyography. After each recording, blood samples were obtained for progesterone and estradiol determination. RESULTS: In the estrous cycle, despite fluctuations of sex hormone levels, no significant changes in gastrointestinal motility were observed. Days 7 and 14 of pregnancy were characterized by significant changes in the frequency of contractions(3.90 ± 0.42 cpm and 3.60 ± 0.36 cpm vs 4.33 ± 0.25 cpm) and gastric emptying(168 ± 17 min and 165 ± 15 min vs 113 ± 15 min) compared with day 0. On these same days, progesterone levels significantly increased compared with control(54.23 ± 15.14 ng/m L and 129.96 ± 30.52 ng/mL vs 13.25 ± 6.31 ng/mL). On day 14, we observed the highest level of progesterone and the lowest level of estradiol compared with day 0(44.3 ± 15.18 pg/mL vs 24.96 ± 5.96 pg/mL). CONCLUSION: Gastrointestinal motility was unaffected by the estrous cycle. In our data, high progesterone and low estradiol levels can be associated with decreased contraction frequency and slow gastric emptying.

关键词： Reproductive physiological process sex hormones Gastrointestinal motility Magnetic fields Gastric emptying

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World Journal of Gastroenterology 2014年第22期20卷 6725-6743页

作者： Mathieu Meleine Julien Matricon Department of Inflammation Nutrition and Gut-Brain Axis DysfunctionInserm Unit 1073Faculté de Médecine et PharmacieUniversité de Rouen76183 RouenFrance Julien Matricon Clermont UniversitéUniversité d’Auvergne63001 Clermont-FerrandFrance Department of Pharmacology. University of Texas Health Science Center San AntonioTX 78229-3900United States

According to epidemiological studies,twice as many women as men are affected by irritable bowel syndrome(IBS)in western countries,suggesting a role for sex hormones in IBS *** growing evidence about the implications of sex hormones in IBS symptom modulation,data on mechanisms by which they influence disease development are *** review aims to determine the state of knowledge about the role of sex hormones in sensorimotor dysfunctions and to address the possible interplay of sex hormones with common risk factors associated with *** scientific bibliography was searched using the following keywords:irritable bowel syndrome,sex,gender,ovarian hormone,estradiol,progesterone,testosterone,symptoms,pain,sensitivity,motility,permeability,stress,immune system,brain activity,spinal,supraspinal,*** hormones variations along themenstrual cycle affect sensorimotor gastrointestinal function in both healthy and IBS *** can modulate pain processing by interacting with neuromodulator systems and the emotional system responsible for visceral pain *** hormones can also modulate the susceptibility to stress,which is a pivotal factor in IBS occurrence and symptom *** instance,estrogen-dependent hyper-responsiveness to stress can promote immune activation or impairments of gut barrier *** conclusion,whereas it is important to keep in mind that ovarian hormones cannot be considered as a causal factor of IBS,they arguably modulate IBS onset and ***,our understanding of the underlying mechanisms remains limited and studies assessing the link between IBS symptoms and ovarian hormone levels are needed to improve our knowledge of the disease evolution with regard to *** studies assessing the role of male hormones are also needed to understand fully the role of sex hormones in ***,investigation of brain-gut interactions is critical to decipher how stress,ovarian hormones,an

关键词： Irritable bowel syndrome Pathophysiology Gender sex hormones Gut Sensori-motricity Neurosensitization Stress Immune activation Permeabilization

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Brain-derived neurotrophic factor, sex hormones and cognitive decline in male patients with schizophrenia receiving continuous antipsychotic therapy

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World Journal of Psychiatry 2023年第12期13卷 995-1004页

作者： Jin Li Wen-Huan Xiao Fei Ye Xiao-Wei Tang Qiu-Fang Jia Xiao-Bin Zhang Department of Psychiatry The Affiliated Guangji Hospital of Soochow UniversitySuzhou 215137Jiangsu ProvinceChina Department of Psychiatry Affiliated Wutaishan Hospital of Medical College of Yangzhou UniversityYangzhou 225000Jiangsu ProvinceChina

BACKGROUND There are systematic differences in clinical features between women and men with schizophrenia(SCZ).The regulation of sex hormones may play a potential role in abnormal neurodevelopment in ***-derived neurotrophic factor(BDNF)and sex hormones have complex interacting actions that contribute to the etiology of *** To investigate the influence of BDNF and sex hormones on cognition and clinical symptomatology in chronic antipsychotic-treated male SCZ *** The serum levels of follicle-stimulating hormone,luteinizing hormone(LH),estradiol(E2),progesterone,testosterone(T),prolactin(PRL)and BDNF were compared between chronic antipsychotic-treated male(CATM)patients with SCZ(n=120)and healthy controls(n=120).The Positive and Negative Syndrome Scale was used to quantify SCZ symptoms,while neuropsychological tests were used to assess *** tests,such as the Digit Cancellation Test(DCT),Semantic Verbal Fluency(SVF),Spatial Span Test(SS),Paced Auditory Serial Addition Test(PASAT),Trail Making Task(TMT-A),and Block Design Test(BDT),were used to assess executive functions(BDT),attention(DCT,TMT-A),memory(SS,PASAT),and verbal proficiency(SVF).RESULTS Although E2 levels were significantly lower in the patient group compared to the healthy controls,T,PRL,and LH levels were all significantly ***,the analysis revealed that across the entire sample,there were positive correlations between E2 Levels and BDNF levels as well as BDNF levels and the digital cancellation *** CATM patients with SCZ,a significant correlation between the negative symptoms score and PRL levels was *** sex hormones and BDNF levels may also be linked to cognitive function in patients with chronic SCZ.

关键词： Brain-derived neurotrophic factor Clinical symptoms Cognitive function Schizophrenia sex hormones

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Examining the Effect of Hydroalcoholic Extract of Dracaena cinnabari on sex hormones and Ovarian and Uterine Tissues of Rats

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World Journal of Traditional Chinese Medicine 2024年第2期10卷 213-219页

作者： Elham Najafi Bahareh Babaei Hoolari Akbar Karimi Aliasghar Pilehvarian Department of Cellular Biology Genesis Evolution-Develoment Isfahan Payame Noor University IsfahanIran Department of Anatomy School of MedicineTehran University of Medical SciencesTehranIran Department of Biology Group Faculty Member of Isfahan Payame Noor UniversityIsfahanIran

Introduction: Dracaena cinnabari is considered a rich source of phytochemicals used widely in traditional medicine. In the present study, the effect of D. cinnabari hydraulic extract on the reproductive system of female rats was investigated. Methods: The samples were randomly divided into four groups(six samples in each group), including three treatment groups and one control group, and all samples were kept at the same conditions. Hydraulic extract of D. cinnabari and injected intraperitoneally daily for 10 days, while physiological serum was used for injection in to the control group. After 10 days of injection, estrogen and progesterone levels were measured by enzyme immunoassay technique. After dissection, the ovaries and uterine tissues were isolated for histological examination, and tissue changes were carefully examined. Results: The results revealed that the levels of estrogen and progesterone in experimental Groups 2 and 3 had a significant increase(P < 0.001). Regarding tissue changes, a significant increase was observed in epithelial thickness(P < 0.001), number of corpus luteum(P < 0.01), and Graafian follicle(P < 0.01) in doses of 100 and 150 mg/kg. Conclusions: Based on the results, it seems that D. cinnabari extract has an effect on the ovarian follicles.

关键词： Dracaena cinnabari herbal medicine ovarian tissues reproductive sex hormones

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The relationship between sex hormones and extent of coronary artery disease in postmenopausal women

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Chinese Medical Journal 2007年第1期120卷 71-73页

作者： Odgerel Tumur HAN Jiang-li YANG Chi-sun MAO Jie-ming Department of Cardiology Peking University Third HospitalBeijing 100083 China Department of Obstetrics and Gynaecology Peking UniversityThird Hospital Beijing 100083 China

The prevalence of coronary artery disease （CAD） in women increases with menopause. Results from the studies on the role of endogenous sex hormones on CAD in postmenopausal women are conflicting. The present study evaluated the relationship between endogenous sex hormones and extent of CAD in postmenopausal women and the associations of sex hormones with CAD risk factors.

关键词： sex hormones coronary artery disease postmenopausal women

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Research on the Effects of the Extract of Polygala fallax Hemsl on sex hormones andβ-EP in Perimenopausal Rat Models

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Journal of Clinical and Nursing Research 2020年第3期4卷 120-124页

作者： Siyuan Yang Zhiyong Cao Jiabao Chen Gang Fang Faculty of Chinese Medicine Science Guangxi University of Chinese MedicineNanning 530200China Guangxi Zhuang Yao Medicine Center of Engineering and Technology Guangxi University of Chinese MedicineNanning 530200China

Objective:To study the effects of the ethnic medicine Polygala fallax Hemsl with Guangxi characteristics on the sex hormones andβ-EP in research objective perimenopausal rat ***:40 female SPF rats were randomly divided into 4 groups,including the normal,model,high-dose and lowdose *** of three groups except for the normal one were treated with perimenopausal modelling through the method of subcutaneous injection of compound 4-VCD for 15 consecutive *** of the normal and model group were normally fed without any *** of the high-dose and low-dose groups were administered by high-and low-dose intragastric administration of the extract of Polygala fallax *** to the menstrual cycle of the vaginal smear of the rat,each menstrual cycle is a course of treatment and 6 consecutive courses of treatment would be *** indexes of serum sex hormones(E2,FSH,LH)andβ-EP of rats in each group were observed after ***:After the treatment of 6 cycles,for the levels ofβ-EP and E2,the model group was lowest(Psex hormones andβ-EP in perimenopausal rat models and relieve the related symptoms with a certain dose-effect relationship.

关键词： Polygala fallax Hemsl Perimenopausal syndrome sex hormones β-EP

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Role of sex hormones on CRH expressing-neurons in the human hypothalamic paraventricular nucleus

Role of sex hormones on CRH expressing-neurons in the human ...

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中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Dick F.SWAAB Netherlands Institute for Neuroscience Meibergdreef 471105 BA Amsterdam ZOThe Netherlands

＜正＞Introduction:The activity of corticotropin-re leasing hormone（CRH） neurons in the hypothalamic paraventricular nucleus（PVN） forms the basis of the activity of the hypothalamo-pituitary-adrenal（HPA）-axis,which is the final common pathway for stress response and for a number of signs and symptoms in specific neurological and psychiatric disorders. A number of studies have pointed to the involvement of sex steroids in the regulation of the stress response and mood *** aimed at determining whether such regulations could be,at least partly,direct effects of sex steroids on the CRH-expressing neurons,via sex hormone ***,the gender difference in age-related number of CRH expressing-neurons and the role of sex hormones on it was also studied. Materials and Methods:Immunocytochemical study:Human hypothalami tissue was obtained from the Netherlands Brain *** monoclonal rat anti-CRH’PFU 83’ antibody and the polyclonal rabbit anti-estrogen receptor（ER）αantibody （MC-20） and polyclonal rabbit anti-androgen receptor（AR） antibody（ARIE） were used for double-labeling of CRH and ERα,and CRH and AR,respectively,in the hypothalamic PVN（virtually no ERβwere found）.CRH and ERαcolocolization was further studied in a depressed-patient-group,which was well-matched for the *** total numbers of CRH neurons in the PVN were also analyzed in 22 control subjects（11 males and 11 females） between the ages of 22 and 89 year, and of 10 subjects with abnormal sex hormone *** assay and co-transfection experiment:The human CRH promoter region was searched and a sequence strongly resembling an androgen responsive element（ARE） was found. Bandshift analysis of this potential ARE was ***,the function of this ARE was investigated by cotransfection of CRH-promoter reporter constructs with AR expression plasmid in SK-N-BE（2）c neuroblastoma ***: Significant correlations between the number of CRH cells and the number of CRH-ERαnuclear

关键词： CRH neurons the HPA axis sex hormones Mood disorders Aging sex difference

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The effects of 17β-trenbolone and bisphenol A on sexual behavior and social dominance via the hypothalamic-pituitary-gonadal axis in male mice

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Journal of Environmental Sciences 2025年第5期151卷 54-67页

作者： Xiang Zuo Minghe Sun Huijuan Bai Shuhui Zhang Jialu Luan Qian Yu Zhenhua Fu Qili Zhao Mingzhu Sun Xin Zhao Xizeng Feng College of Life Science State Key Laboratory of Medicinal Chemical BiologyThe Key Laboratory of Bioactive MaterialsMinistry of EducationNankai UniversityTianjin 300071China Institute of Robotics&Automatic Information System College of Artificial IntelligenceNankai UniversityTianjin 300071China

17β-Trenbolone(17-TB)is well documented as an environmental endocrine disruptor in aquatic biological studies,but its effects on mammals remain poorly ***,17-TB acts as a hormone with properties similar to testosterone,and the consequences of juvenile exposure on adult social behavior remain *** A(BPA)acts as an estrogen-like hormone,compared to ***-week-old male Balb/c mice were exposed orally to 17-TB(100μg/(kg·day))and BPA(4 mg/(kg·day))for 28 *** of social interactions and a three-chamber test showed that 17-TB increased virility in male mice,intensified both male and female sexual behavior,and attracted and accepted female *** also increased social dominance through tube tests inmalemice and markedly activated the c-Fos^(+)immune response in themedial prefrontal cortex(mPFC)and basal amygdala(BLA).ELISA data showed that 17-TB and BPA exposure significantly affected serum gonadotropin-releasing hormone(GnRH),growth hormone(GH),estradiol(E2),and luteinizing hormone(LH)levels,as well as testicular lesions and androgen receptor(ARβ)and estrogen receptor(ERα)*** transcriptomic analysis further confirmed that could disrupt steroid synthesis and linoleic acid-related biometabolic *** findings suggest the influence of 17-TB and BPA exposure on sexual behavior and fertility in male mice,possibly through modulation of the hypothalamic-pituitary-gonadal *** study provides insights relevant to human reproductive health and neuro-social behavioral research,and the potential risk of environmental disturbances should not be overlooked.

关键词： 17β-Trenbolone(17-TB) Bisphenol A(BPA) hypothalamic-pituitary-gonadal axis(HPG) sex hormones Social dominance sexual behavior

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