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Effectiveness and Safety of Double-balloon Catheter versus Intra-amniotic Injection of Ethacridine Lactate for Termination of Second Trimester Pregnancy in Patients with liver dysfunction

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2015年第1期35卷 129-134页

作者：李娜吴鹏赵捷冯玲乔福元曾万江 Department of Obstetrics and Gynecology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology

severe liver dysfunction in pregnancy（SLDP） is rare but serious complications with high mortality rate. This study compared the effectiveness and safety of double-balloon catheter versus intra-amniotic injection of ethacridine lactate for the termination of second trimester pregnancy in patients with SLD. A total of 55 patients with indications of labor induction were enrolled and analyzed by retrospective control analysis method. Twenty-three cases adopted Cook double balloon dilation as Cook group, and 32 cases received intra-amniotic injection of ethacridine lactate as EL group. The primary outcome was evaluated by successful abortion rate and the difference in the induction-to-abortion interval. Secondary outcomes included liver function recovery and the frequency of adverse events. Both Cook and EL regimens were effective, with successful abortion rate of 87.0% and 93.8%, respectively（P=0.639）. The induction-to-delivery interval was similar between Cook group and EL group（38.1±21.5 vs. 41.3±17.4, P=0.543）. The liver disease status was more severe in Cook group than in EL group, but it did not show any significant difference after pregnancy termination between the two groups and the improvement rate also did not show any significant difference. Both treatments were safe and there was no significant difference in bleeding and cervical laceration adverse events between the two groups. Our study firstly compared double-balloon catheter and ethacridine lactate for the induction of labor in women with SLD during second trimester pregnancy.

关键词： severe liver dysfunction labor induction double-balloon catheter mechanical method ethacridine lactate

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Reliability of neutrophil gelatinase-associated lipocalin in detecting acute tubular necrosis in decompensated cirrhosis:Systematic review and meta-analysis

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World Journal of Hepatology 2024年第11期16卷 1331-1338页

作者： Nirav Agrawal Scarlet Louis-Jean Zoya Ladiwala Harsha Adnani Ayesha Kamal Mitchell Karpman Albert Steven Fleisher Sanmeet Singh Department of Internal Medicine Anne Arundel Medical CenterAnnapolisMD 21401United States Department of Biostatistics Anne Arundel Medical CenterAnnapolisMD 21401United States Department of Gastroenterology Anne Arundel Medical CenterAnnapolisMD 21401United States

BACKGROUND Acute kidney injury(AKI)in cirrhosis is *** diagnosis of AKI in cirrhosis patients depends on clinical presentation and laboratory tests like serum ***,urine biomarkers could also be used to assess the type of AKI and the severity of the *** performed a systematic review with metaanalysis to evaluate the association with urine neutrophil gelatinase-associated lipocalin(NGAL)marker in identifying acute tubular necrosis(ATN)in patients with *** To assess the reliability of urine NGAL in the detection of ATN in patients with *** We systematically searched MEDLINE and PubMed using keywords including“urine biomarkers”,“NGAL”,“kidney dysfunction”,and“cirrhosis”to identify relevant *** was screened and *** studies assessed hospitalized cirrhosis patients with AKI using the urine NGAL *** synthesized the data using diagnostic odds ratio(DOR),comparative and descriptive analyses,and Cochran Mantel-Haenszel(CMH)statistics to evaluate *** Three thousand seven hundred and one patients with cirrhosis were analyzed from a total of 21 cohort *** DOR of 14 of those studies[pooled DOR:22.150,(95%CI:17.58-27.89),P<0.0001]demonstrated a significant association between urine NGAL levels and its identification of *** stratification by cirrhosis status,heterogeneity was analyzed and showed a significant non-zero correlation between NGAL and AKI(CMH statistic=702.19,P<0.0001).CONCLUSION In patients with cirrhosis,the use of urine NGAL is a reliable biomarker for detecting ATN and identifying the etiology of AKI.

关键词： Neutrophil gelatinase-associated lipocalin Acute tubular necrosis Acute kidney injury Cirrhosis Biomarker severe liver dysfunction

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