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sevelamer as an efficient and reusable heterogeneous catalyst for the Knoevenagel reaction in water

Chinese Chemical Letters 2014年第8期25卷 1141-1144页

作者： Xian-Liang Zhao Ke-Fang Yang Yan-Ping Zhang Ju Zhu Li-Wen Xu School of Biological and Chemical Engineering Zhejiang University of Science and Technology Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education Hangzhou Normal University

A catalyst system of sevelamer, a phosphate-binding drug, has been prepared and used in the Knoevenagel reaction of aromatic aldehydes in water to produce substituted electrophilic alkenes. The products were obtained in excellent yields. Several novel, related catalytic systems showed promising catalytic properties for aromatic and heterocyclic aldehydes. The sevelamer catalyst can be recovered using simple filtration and reused numerous times（up to 15 times） in the aqueous Knoevenagel reaction without any significant lowering of activity.

关键词： Knoevenagel reaction sevelamer Recycle Heterogeneous

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Lower gastrointestinal bleeding: Association with sevelamer use

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World Journal of Gastroenterology 2008年第16期14卷 2615-2616页

作者： Pankaj Madan Suverta Bhayana Prakash Chandra John I Hughes Department of Medicine Baylor College of Medicine

Stercoral ulceration results from impaction of hard fecal mass on the colonic wall and is a relatively unknown cause of lower gastrointestinal bleeding. In this report, we describe a case of lower gastrointestinal ble... 详细信息

关键词： Stercoral Ulcer sevelamer Chronic renalfailure Lower gastrointestinal bleeding

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Effect of sevelamer Hydrochloride on the Serum Calcitriol Concentration in Hemodialysis Patients

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International Journal of Clinical Medicine 2014年第20期5卷 1320-1327页

作者： Kazumichi Matsushita Keitaro Sato Kohei Unagami Kosaku Nitta Kiichiro Tago Matsushita Nephrology Clinic Yamanashi Japan Department of Medicine Kidney Center Tokyo Women’s Medical University Tokyo Japan

Back ground: There are no published clinical data in hemodialysis (HD) patients with mineral bone disorder (CKD-MBD) regarding the effect of sevelamer hydrochloride on the absorption of the oral calcitriol. Objectives: The aim of the present study was to determine the association of the sevelamer hydrochloride and serum 1-25(OH)2D concentration during oral calcitriol therapy. Methods: This was a before-and-after study in HD patients. Forty-six patients co-administered with phosphate-binder and calcitriol for CKD-MBD therapy took lanthanum carbonate (LC) and sevelamer hydrochloride (SH) for 4 weeks, respectively with calcitriol. The serum 1-25(OH)2D concentration was assessed after each period. Results: Serum 1-25(OH)2D concentration was significantly reduced with co-administration of SH compared to LH (mean, calcitriol with LC→SH: 19.9 pg/ml → 14.2 pg/ml, p 2D concentrations after oral calcitriol administration compared to LH in HD patients. When we use SH as a phosphate binder with calcitriol for HD patients with CKD-MBD, we should consider the inhibitory effect of SH on oral calcitriol absorption.

关键词： Hemodialysis Calcitriol sevelamer Hydrochrolide Lanthanum Carbonate Bioavailability

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Vascular calcification:When should we interfere in chronic kidney disease patients and how?

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World Journal of Nephrology 2016年第5期5卷 398-417页

作者： Usama Abdel Azim Sharaf El Din Mona Mansour Salem Dina Ossama Abdulazim Department of Nephrology School of MedicineCairo UniversityCairo 11759Egypt Department of Endocrinology School of MedicineCairo UniversityCairo 11759Egypt Department of Rheumatology and Rehabilitation School of MedicineCairo UniversityCairo 11759Egypt

Chronic kidney disease （CKD） patients are endangered with the highest mortality rate compared to other chronic diseases. Cardiovascular events account for up to 60% of the fatalities. Cardiovascular calcifcations affect most of the CKD patients. Most of this calcification is related to disturbed renal phosphate handling. Fibroblast growth factor 23 and klotho defciency were incriminated in the pathogenesis of vascular calcification through different mechanisms including their effects on endothelium and arterial wall smooth muscle cells. In addition, deficient klotho gene expression, a constant feature of CKD, pro-motes vascular pathology and shares in progression of the CKD. The role of gut in the etio-pathogenesis of systemic infammation and vascular calcifcation is a newly discovered mechanism. This review will cover the medical history, prevalence, pathogenesis, clinical relevance, different tools used to diagnose, the ideal timing to prevent or to withhold the progression of vascular cal-cification and the different medications and medical procedures that can help to prolong the survival of CKD patients.

关键词： Chronic kidney disease Uremia Calcifcation sevelamer Calcific uremic arteriolopathy Fibroblast growth factor 23 Klotho Phosphate binders Kidney transplantation

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