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5’tiRNA-Pro-TGG,a novel tRNA halve,promotes oncogenesis in sessile serrated lesions and serrated pathway of colorectal cancer

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World Journal of Gastrointestinal Oncology 2023年第6期15卷 1005-1018页

作者： Xin-Yuan Wang Yu-Jie Zhou Hai-Ying Chen Jin-Nan Chen Shan-Shan Chen Hui-Min Chen Xiao-Bo Li Division of Gastroenterology and Hepatology Renji HospitalShanghai Jiaotong University School of MedicineShanghai 200000China Department of Spleen and Stomach and Rheumatology Affiliated Traditional Chinese Medicine Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina

BACKGROUND Transfer RNA(tRNA)-derived small RNAs(tsRNAs)are small fragments that form when tRNAs *** halves(tiRNAs),a subcategory of tsRNA,are involved in the oncogenic processes of many ***,their specific role in sessile serrated lesions(SSLs),a precancerous lesion often observed in the colon,has not yet been *** To identify SSL-related tiRNAs and their potential role in the development of SSLs and serrated pathway of colorectal cancer(CRC).METHODS Small-RNA sequencing was conducted in paired SSLs and their adjacent normal control(NC)*** expression levels of five SSL-related tiRNAs were validated by q-polymerase chain *** counting kit-8 and wound healing assays were performed to detect cell proliferation and *** target genes and sites of tiRNA-1:33-Pro-TGG-1(5′tiRNA-Pro-TGG)were predicted by TargetScan and miRanda ***-associated and immune-related pathways were analyzed by single-sample gene set enrichment *** analyses were performed to establish the roles of 5′tiRNA-Pro-TGG based on the target *** In total,we found 52 upregulated tsRNAs and 28 downregulated tsRNAs in SSLs compared to *** expression levels of tiRNA-1:33-Gly-CCC-2,tiRNA-1:33-Pro-TGG-1,and tiRNA-1:34-Thr-TGT-4-M25′tiRNAs were higher in SSLs than those in NC,while that of 5′tiRNA-Pro-TGG was associated with the size of *** was demonstrated that 5′tiRNAPro-TGG promoted cell proliferation and migration of RKO cell in ***,heparanase 2(HPSE2)was identified as a potential target gene of 5′*** lower expression was associated with a worse prognosis in ***,lower expression of HPSE2 was observed in SSLs compared to normal controls or conventional adenomas and in BRAF-mutant CRC compared to BRAF-wild *** analyses revealed that its low expression was associated with a low interferonγresponse and also with many metabolic pathways such as riboflavin,retinol,and cy

关键词： Noncoding RNA tRNA halves sessile serrated lesions Colon cancer serrated pathway

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Current progress on the endoscopic features of colorectal sessile serrated lesions

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World Journal of Clinical Oncology 2023年第4期14卷 171-178页

作者： Rui-Gang Wang Lai Wei Bo Jiang Department of Gastroenterology Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 102218China Department of Digestive Medicine Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 102218China

Along with the discovery and refinement of serrated pathways,the World Health Organization amended the classification of digestive system tumors in 2019,recommending the renaming of sessile serrated adenomas/polyps to sessile serrated lesions(SSLs).Given the particularity of the endoscopic appearance of SSLs,it could easily be overlooked and missed in colonoscopy screening,which is crucial for the occurrence of interval colorectal *** literature has found that adequate bowel preparation,reasonable withdrawal time,and awareness of colorectal SSLs have improved the quality and accuracy of *** particularly,with the continuous advancement and development of endoscopy technology,equipment,and accessories,a potent auxiliary tool is provided for accurate observation and immediate diagnosis of *** white light endoscopy,chromoendoscopy,and magnifying endoscopy have distinct roles in the detection of colorectal SSLs and are valuable in identifying the size,shape,character,risk degree,and potential malignant *** article delves into the relevant factors influencing the detection rate of colorectal SSLs,reviews its characteristics under various endoscopic techniques,and expects to attract the attention of colonoscopists.

关键词： Colorectal cancer sessile serrated lesions Endoscopic features

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Usefulness of analyzing endoscopic features in identifying the colorectal serrated sessile lesions with and without dysplasia

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World Journal of Clinical Cases 2023年第29期11卷 6995-7003页

作者： Rui-Gang Wang Yu-Tang Ren Xuan Jiang Lai Wei Xiao-Fei Zhang Hao Liu Bo Jiang Department of Gastroenterology Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 102218China Center for Hepatobiliary and Pancreatic Diseases Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 102218China Center for Clinical Epidemiology and Statistics Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 102218China Department of Pathology Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 102218China

BACKGROUND sessile serrated lesions(SSLs)are often missed on colonoscopy,and studies have shown this to be an essential cause of interstitial colorectal *** SSLs with dysplasia(SSL-D+),in particular,have a faster rate of carcinogenesis than conventional tubular ***,there is a clinical need for some endoscopic features with independent diagnostic value for SSL-D+s to assist endoscopists in making immediate diagnoses,thus improving the quality of endoscopic examination and *** To compare the characteristics of SSLs,including those with and without dysplasia(SSL-D+and SSL-D-),based on white light and image-enhanced endoscopy,to achieve an immediate differential diagnosis for *** From January 2017 to February 2023,cases of colorectal SSLs confirmed by colonoscopy and histopathology at the Gastrointestinal Endoscopy Center of Beijing Tsinghua Changgung Hospital were *** general,endoscopic,and histopathological data were reviewed and analyzed to determine the diagnostic *** analysis was used to find potential diagnostic factors,and then multivariate regression analysis was performed to derive endoscopic features with independent diagnostic values for the SSL-D+.RESULTS A total of 228 patients with 253 lesions were collected as a *** were 225 cases of colorectal SSL-D-s and 28 cases of SSL-D+*** to the colorectal SSL-D-,the SSL-D+was more common in the right colon(P=0.027)with complex patterns of depression,nodule,and elevation based on cloud-like surfaces(P=0.003),reddish(Plesions had a reddish color[odds ratio(OR)=18.705,95%confidence interval(CI):3.684-94.974],microvascular varicose(OR=6.768,95%CI:1.717-26.677),and mixed pattern of crypt opening(OR=20.704,95%CI:2.955-145.086)as the independent predictors fo

关键词： sessile serrated lesions Dysplasia Endoscopic features

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What could microRNA expression tell us more about colorectal serrated pathway carcinogenesis?

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World Journal of Gastroenterology 2020年第42期26卷 6556-6571页

作者： Milena Peruhova Monika Peshevska-Sekulovska Boris Krastev Gabriela Panayotova Viktoriya Georgieva Rossitza Konakchieva Georgi Nikolaev Tsvetelina Veselinova Velikova Department of Gastroenterology University Hospital LozenetzSofia 1407Bulgaria Medical Faculty Sofia University St.Kliment OhridskiSofia 1407Bulgaria Department of Clinical Oncology MHAT Hospital for Women Health NadezhdaSofia 1330Bulgaria Faculty of Biology Sofia University St.Kliment OhridskiSofia 1407Bulgaria Department of Clinical Immunology University Hospital LozenetzSofia 1407Bulgaria

In the last two decades,the vision of a unique carcinogenesis model for colorectal carcinoma(CRC)has completely *** addition to the adenoma to carcinoma transition,colorectal carcinogenesis can also occur via the serrated *** non-coding RNA,known as microRNAs(miRNAs),were also shown to be involved in progression towards ***,increased expression of certain miRNAs in premalignant sessile serrated lesions(SSLs)was found,emphasizing their role in the serrated pathway progression towards colon *** miRNAs function as post-transcriptional gene regulators,they have enormous potential to be used as useful biomarkers for CRC and screening in patients with SSLs *** this review,we have summarized the most relevant information about the specific role of miRNAs and their relevant signaling pathways among different serrated lesions and polyps as well as in serrated *** focus is put on the correlation between gut immunity and miRNA expression in the serrated pathway,which remains unstudied.

关键词： MicroRNA serrated pathway Carcinogenesis Colorectal carcinoma sessile serrated lesions Adenocarcinoma

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serrated lesions:A challenging enemy

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World Journal of Gastroenterology 2021年第34期27卷 5625-5629页

作者： Alexa Trovato Alla Turshudzhyan Micheal Tadros Albany Medical College AlbanyNY 12208United States Department of Medicine University of ConnecticutSchool of MedicineFarmingdaleCT 06032United States Department of Gastroenterology Albany Medical CenterAlbanyNY 12208United States

The serrated pathway accounts for 30%-35%of colorectal cancer(CRC).Unlike hyperplastic polyps,both sessile serrated lesions(SSLs)and traditional serrated adenomas are premalignant lesions,yet SSLs are considered to be the principal serrated precursor of *** lesions represent a challenge in detection,classification,and removal–contributing to post-colonoscopy ***,it is of the utmost importance to characterize these lesions properly to ensure complete removal.A retrospective cohort study developed a diagnostic scoring system for SSLs to facilitate their detection endoscopically and subsequent *** the study,it can be ascertained that both indistinct border and mucus cap are essential in both recognizing and diagnosing serrated *** proximal colon poses technical challenges for some endoscopists,which is why high-quality colonoscopy plays such an important *** indistinct border of some SSLs poses another challenge due to difficult complete ***,it is imperative that gastroenterologists use the key features of mucus cap,indistinct borders,and size of at least five millimeters along with a high-quality colonoscopy and a good bowel preparation to improve the SSL detection rate.

关键词： sessile serrated lesions Colonoscopy Polyps Colorectal cancer screening Hyperplastic polyps Traditional serrated adenomas

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How to"pick up"colorectal serrated lesions and polyps in daily histopathology practice:From terminologies to diagnostic pitfalls

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World Journal of Clinical Oncology 2024年第9期15卷 1157-1167页

作者： Thai H Tran Vinh H Nguyen Diem TN Vo Department of Pathology Da Nang HospitalDa Nang 50000Viet Nam Department of Pathology University Medical Center Ho Chi Minh CityHo Chi Minh 70000Viet Nam Department of Histology-Embryology and Pathology University of Medicine and Pharmacy at Ho Chi Minh CityHo Chi Minh 70000Viet Nam

Over the last decade,our knowledge of colorectal serrated polyps and lesions has significantly improved due to numerous studies on this group of precursor *** lesions were misleading as benign before 2010,but they are currently reclassified as precancerous lesions that contribute to 30%of colorectal cancer through the serrated neoplasia *** World Health Organization updated the classification for serrated lesions and polyps of the colon and rectum in 2019,which is more concise and applicable in daily *** responsible authors prescribe that“colorectal serrated lesions and polyps are characterized by a serrated(sawtooth or stellate)architecture of the epithelium.”From a clinical standpoint,sessile serrated lesion(SSL)and SSL with dysplasia(SSLD)are the two most significant *** these advancements,the precise diagnosis of SSL and SSLD based mainly on histopathology remains challenging due to various *** review describes the nomenclature and the terminology of colorectal serrated polyps and lesions and highlights the diagnostic criteria and obstacles encountered in the histopathological diagnosis of SSL and SSLD.

关键词： sessile serrated lesions sessile serrated lesions with dysplasia serrated polyps sessile serrated adenoma Benign hyperplastic polyps serrated lesions/polyps

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