检索结果-南通市图书馆

Efficacy of concurrent chemoradiotherapy with thalidomide and S-1 for esophageal carcinoma and its influence on serum tumor markers

引用

World Journal of Gastrointestinal Oncology 2023年第7期15卷 1262-1270页

作者： Tian-Wei Zhang Peng Zhang Dong Nie Xin-Yu Che Tian-Tai Fu Yan Zhang Department of Hematology and Radiotherapy Zibo 148 HospitalZibo 255300Shandong ProvinceChina

BACKGROUND Although the current conventional treatment strategies for esophageal carcinoma(EC)have been proven effective,they are often accompanied by serious adverse ***,it is still necessary to continue to explore new therapeutic strategies for EC to improve the clinical outcome of *** To elucidate the clinical efficacy of concurrent chemoradiotherapy(CCRT)with thalidomide(THAL)and S-1(tegafur,gimeracil,and oteracil potassium capsules)in the treatment of EC as well as its influence on serum tumor markers(STMs).METHODS First,62 patients with EC treated at the Zibo 148 Hospital between November 2019 and November 2022 were selected and grouped according to the received *** these,30 patients undergoing CCRT with cis-platinum and 5-fluorouracil were assigned to the control group(Con),and 32 patients receiving CCRT with THAL and S-1 were assigned to the research group(Res).Second,inter-group comparisons were carried out with respect to curative efficacy,incidence of drug toxicities,STMs[carbohydrate antigen 125(CA125)and macrophage inflammatory protein-3α(MIP-3α)],angiogenesis-related indicators[vascular endothelial growth factor(VEGF);VEGF receptor-1(VEGFR-1);basic fibroblast growth factor(bFGF);angiogenin-2(Ang-2)],and quality of life(QoL)[QoL core 30(QLQ-C30)]after one month of *** The analysis showed no statistical difference in the overall response rate and disease control rate between the two patient cohorts;however,the incidences of grade I–II myelosuppression and gastrointestinal reactions were significantly lower in the Res than in the ***,the post-treatment CA125,MIP-3α,VEGF,VEGFR-1,bFGF,and Ang-2 Levels in the Res were markedly lower compared with the pre-treatment levels and the corresponding post-treatment levels in the ***,more evident improvements in QLQ-C30 scores from the dimensions of physical,role,emotional,and social functions were determined in the *** The above results d

关键词： Thalidomide Concurrent chemoradiotherapy Esophageal carcinoma Therapeutic effect serum tumor markers

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

serum tumor markers for detection of hepatocellular carcinoma

引用

World Journal of Gastroenterology 2006年第8期12卷 1175-1181页

作者： Lin Zhou Jia Liu Feng Luo Division of Biotherapy for Cancer Cancer Center West China Hospital'ofSichuan University Chengdu 610041 Sichuan Province China Cancer Center West China Hospital of Sichuan University Chengdu 610041 Sichuan Province China

Hepatocellular carcinoma （HCC） is one of the most frequent malignant tumors and is the second most common cause of cancer death in China. Therefore, it is very important to detect this disease and the recurrence at its earlier period. serum tumor markers, as the effective method for detecting hepatocellular carcinoma for a long time, could be divided into 4 categories： oncofetal antigens and glycoprotein antigens; enzymes and isoenzymes; genes; and cytokines. serum alpha fetoprotein （AFP） is the most widely used tumor marker in detecting patients with hepatocellular carcinoma, and has been proven to have capability of prefiguring the prognosis. However, it has been indicated that AFP-L3 and DCP excel AFP in differentiating hepatocellular carcinoma from nonmalignant hepatopathy and detecting small hepatocellular carcinoma. Some tumor markers, such as human cervical cancer oncogene and human telomerase reverse transcriptase mRNA, have also been indicated to have higher accuracies than AFP. Furthermore, some other tumor markers, such as glypican-3, gamma-glutamyl transferase Ⅱ, alpha-Ifucosidase, transforming growth factor-beta1, tumorspecific growth factor, have been indicated to be available supplementaries to AFP in the detection. AFP mRNA has been shown to correlate with the metastasis and recurrence of HCC, and it may be the most useful marker to prefigure the prognosis. Some other markers, such as gamma-glutamyl transferase mRNA, vascular endothelial growth factor, and interleukin-8, could also be used as available prognostic indicators, and the simultaneous determination of AFP and these markers may detect the recurrence of HCC at its earlier period.

关键词： Hepatocellular carcinoma serum tumor markers Sensitivity Specificity Prognosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The real-world research of lung cancer-associated autoantibodies and serum tumor markers

The real-world research of lung cancer-associated autoantibo...

引用

2021年中国肿瘤标志物学术大会暨第十五届肿瘤标志物青年科学家论坛

作者： Feng Chen Xiaoqian Xu Fan Ren Jun Chen Song Xu 天津医科大学总医院

Background: Lung cancer is one of the most common malignant tumors in the world, and it is also the main cause of death for both sexes. Early detection and treatment are considered to be the main means to reduce mortality. At present, the strategy of lung cancer screening is conducting low-dose computed tomography(LDCT), however there is risk of false positivity and radiation exposure. In order to avoid these problems, some hematological biomarkers are used in the auxiliary diagnosis and screening of lung cancer. Currently, serum tumor markers and seven autoantibodies are widely used *** and Methods: Enzyme-linked immunosorbent assay(ELISA) is used to detect the expression levels and positive expression rate of seven autoantibodies(AABs) and tumor markers in serum of 354 patients with lung cancer and 108 patients with benign pulmonary diseases in the real ***: Through the analysis of real-world data, the sensitivity, specificity, PPV and area under ROC curve of seven AABs were 30.0%, 84.3%,86.3% and 0.61 respectively;the sensitivity of seven AABs combined with tumor markers was 68.6%, the specificity was 52.8%, and the area under the ROC curve was 0.72. The positive expression rate of seven AABs in patients with lung cancer was significantly higher than those with benign expression diseases(30.1% vs. 15.7%). Combined seven AABs with tumor markers, the positive rates increased to 68.6%. The positive expression of seven AABs was affected by clinical features and pathological stages, among which the expression rate of stage I was the lowest, only 17.1%.Conclusion: Through the analysis of real-world data, the value of seven AABs as auxiliary diagnosis of lung cancer has been affirmed. However, due to its low sensitivity and susceptibility to clinical features, its application in lung cancer screening is limited. After the combination of tumor markers,although the sensitivity increased, but the specificity decreased, the false positive rate inc

关键词： Lung cancer Seven autoantibodies serum tumor markers Diagnosis Early screening

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Impact of oxaliplatin and trastuzumab combination therapy on tumor markers and T lymphocyte subsets for advanced gastric cancer

引用

World Journal of Gastrointestinal Oncology 2024年第9期16卷 3905-3912页

作者： Cheng-Wan Zheng Yun-Mo Yang Hui Yang Department of Thyroid Surgery The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina

BACKGROUND Advanced gastric cancer(AGC)remains a challenging malignancy with poor *** combination of oxaliplatin and trastuzumab has shown promising results in AGC *** study aimed to investigate the effects of oxaliplatin and trastuzumab combination therapy on serum tumor markers and T lymphocyte subsets in patients with AGC and to explore their potential as predictive biomarkers for treatment *** To investigate the impact of oxaliplatin and trastuzumab combination therapy on serum markers and T cell subsets in patients with *** This prospective study enrolled 60 patients with *** patients received oxaliplatin(130 mg/m^(2),every 3 weeks)and trastuzumab(8 mg/kg loading dose,followed by 6 mg/kg every 3 weeks)for six *** carcinoembryonic antigen(CEA),cancer antigen 19-9(CA19-9),and cancer antigen 72-4(CA72-4)were measured before and after treatment.T-lymphocyte subsets,including CD3+,CD4+,CD8+,and CD4+/CD8+ratios,were also *** clinical response was assessed using the Response Evaluation Criteria in Solid tumors version *** After six cycles of treatment,the CEA,CA19-9,and CA72-4 serum levels significantly decreased compared to baseline levels(Pserum tumor markers(≥50%reduction)and a higher increase in CD4+/CD8+ratio(≥1.5-fold)showed better clinical response rates(Pserum tumor marker levels and modulated T lymphocyte subsets in patients with *** therapy not only has a direct antitumor effect,but also enhances the immune response in patients with *** tumor markers and T lymphocyte subsets may serve as potential predictive biomarkers for treatment respon

关键词： Advanced gastric cancer Oxaliplatin Trastuzumab serum tumor markers T lymphocyte subsets Predictive biomarkers

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Validation of serum tumor biomarkers in predicting advanced cystic mucinous neoplasm of the pancreas

引用

World Journal of Gastroenterology 2021年第6期27卷 501-512页

作者： Li-Qi Sun Li-Si Peng Jie-Fang Guo Fei Jiang Fang Cui Hao-Jie Huang Zhen-Dong Jin Department of Gastroenterology Changhai HospitalSecond Military Medical UniversityShanghai 200433China

BACKGROUND Early detection of advanced cystic mucinous neoplasms[(A-cMNs),defined as high-grade dysplasia or malignancy]of the pancreas is of great *** a simple and feasible detection method,serum tumor markers(STMs)may be used to predict advanced intraductal papillary mucinous neoplasms(IPMNs)and mucinous cystic neoplasms(MCNs).However,there are few studies on the usefulness of STMs other than carbohydrate antigen(CA)19-9 for early detection of *** To study the ability of five STMs-CA19-9,carcinoembryonic antigen(CEA),CA125,CA724,and CA242 to predict A-cMNs and distinguish IPMNs and *** We mainly measured the levels of each STM in patients pathologically diagnosed with *** mean levels of STMs and the number of A-cMN subjects with a higher STM level than the cutoff were compared respectively to identify the ability of STMs to predict A-cMNs and distinguish MCNs from IPMNs.A receiver operating characteristic curve with the area under curve(AUC)was also created to identify the performance of the five *** A total of 187 patients with cMNs were identified and 72 of them showed *** found that CA19-9 exhibited the highest sensitivity(SE)(54.2%)and accuracy(76.5%)and a moderate ability(AUC=0.766)to predict *** predicting high-grade dysplasia IPMNs,the SE of CA19-9 decreased to 38.5%.The ability of CEA,CA125,and CA724 to predict A-cMNs was low(AUC=0.651,0.583,and 0.618,respectively).The predictive ability of CA242 was not *** combination of STMs improved the SE to 62.5%.CA125 may be specific to the diagnosis of advanced *** CA19-9 has a moderate ability,and CEA,CA125,and CA724 have a low ability to predict *** combination of STM testing could improve SE in predicting A-cMNs.

关键词： serum tumor markers Diagnosis Advanced cystic mucinous neoplasms Mucinous cystic neoplasms Intraductal papillary mucinous neoplasms

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Laparoscopic vs open surgery for gastric cancer: Assessing time, recovery, complications, and markers

引用

World Journal of Gastrointestinal Surgery 2024年第1期16卷 40-48页

作者： Yun-Yao Lu Yun-Xiao Li Meng He Ya-Li Wang Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment Chongqing University Cancer HospitalChongqing 400030China

BACKGROUND Gastric cancer(GC)is one of the most common cancers *** and mortality have increased in recent years,making it an urgent issue to ***-paroscopic radical surgery(LRS)is a crucial method for treating patients with GC;However,its influence on tumor markers is still under *** data of 194 patients treated at Chongqing University Cancer Hospital bet-ween January 2018 and January 2019 were retrospectively *** who underwent traditional open surgery and LRS were assigned to the control(n=90)and observation groups(n=104),*** sample t-tests andχ2 tests were used to compare the two groups based on clinical efficacy,changes in tumor marker levels after treatment,clinical data,and the incidence of posto-perative *** investigate the association between tumor marker levels and clinical efficacy in patients with GC,three-year recurrence rates in the two groups were *** Patients in the observation group had a shorter duration of operation,less in-traoperative blood loss,an earlier postoperative eating time,and a shorter hospital stay than those in the control group(P0.05).After treatment,the overall response rate in the control group was significantly lower than that in the observation group(P=0.001).Furthermore,after treatment,the levels of carbohydrate antigen 19-9,cancer antigen 72-4,carcinoembryonic antigen,and cancer antigen 125 decreased *** observation group also exhibited a significantly lower incidence rate of postoperative complications compared to the control group(P0.05).CONCLUSION LRS effectively treats early gastric cancer by reducing intraoperative bleeding,length of hospital stays,and postoperative complications.I

关键词： Laparoscopic radical surgery Gastric cancer serum tumor markers Prognosis Recurrence Intraoperative bleeding

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Study on relationship between paraneoplastic syndrome and nerver system injury

引用

中国组织工程研究 2002年第5期6卷 768-768页

作者：郭晓玲李柱一 Fourth Military Medical University Xi' an 710038 China

Non-metastatic or invaded neoplasms sometimes produce distal effects in nervous system,nerve-muscle junction and muscle i.e paraneoplastic syndrome(PNS).PNS is diverse in clinical *** system symptoms and neoplasm may occur simultaneously or months-years ***,clinical diagnosis and management are very *** is our report about clinical manifestations in 23 PNS patients admitted in our department. 1 Subjects data 25 PNS patients including 18 males and 7 females,aging from 20～ 76(mean age:54.2) were included in our *** consisted of pulmonary cancer(n=16),digestive system tumor(n=3),leukemia(n=1),cervical carcinoma(n=1). All nervous system symptoms occur earlier than neoplasm *** cervical carcinoma patients(1 month～ 6 year,mean:10 months). serum tumor markers was increased in 22 *** symptoms:myasthenic syndrome was observed in 11 subjects,asthenia of extremities in 8 subjects,asthenia of bilateral lower limbs in 3 subjects,peripheral neuropathy in 9 subjects,numbness of limbs in 4 cases,brachia plexus injury in 1 subject,greater occipital nerve pain in 2 cases,ischialgia neuralgia in 1 subjects,muscle atrophy in 6 subjects,acute transverse myelophthy in 1 subject,progressive multifocal leukoencephalopathy in 1 subject. 2 Discussion Myasthenic syndrome is more common among these symptoms such as myopathy,peripheral neuropathy,spinal disease,*** is diverse in clinical *** to these symptoms,tumor is very available if diagnosis of nervous system disease could not be *** carcinoma,mammary carcinoma,digestive system tumor,cervical carcinoma,adrenal tumor esp. pulmonary carcinoma may be the causes of *** may occur 15 years earlier than *** PNS is determined,disease status should be actively observed and primary lesion be *** could be confirmed if (1)Aged over 40;(2)Existence of serum tumor ***,TPA and NSE increased in 22 *** addit

关键词：副肿瘤神经系统损害相关分析 nervous system cervical carcinoma serum tumor markers diagnosis of paraneoplastic syndrome pulmonary cancer liquid pressure abdominal pain lower limbs

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：