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Efficacy and anti-inflammatory analysis of glucocorticoid,antihistamine and leukotriene receptor antagonist in the treatment of allergic rhinitis

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World Journal of Clinical Cases 2023年第28期11卷 6725-6732页

作者： Chen Qiu Dai Feng Department of Pharmacy Hongshan District Health Service CenterWuhan 430000Hubei ProvinceChina Department of Ear-Nose-Throat Wuchang Hospital Affiliated to Wuhan University of Science and TechnologyWuhan 430063Hubei ProvinceChina

BACKGROUND There are many adverse reactions in the treatment of allergic rhinitis(AR)mainly with conventional *** receptor antagonists,glucocorticoids and nasal antihistamines can all be used as first-line drugs for AR,but the clinical effects of the three drugs are not *** To examine the impact of glucocorticoids,antihistamines,and leukotriene receptor antagonists on individuals diagnosed with AR,specifically focusing on their influence on serum inflammatory *** The present retrospective study focused on the clinical data of 80 patients diagnosed and treated for AR at our hospital between May 2019 and May *** participants were categorized into the control group and the observation *** control group received leukotriene receptor antagonists,while the observation group was administered glucocorticoids and *** an observation and comparison of the symptoms,physical sign scores,adverse reactions,and effects on serum inflammatory indexes in two distinct groups of patients,both before and after *** Subsequent to treatment,the nasal itching score,sneeze score,runny nose score,nasal congestion score,and physical signs score exhibited notable discrepancies(P<0.05),with the observation group demonstrating superior outcomes compared to the control group(P<0.05).The interleukin(IL)-6,IL-10,tumor necrosis factor-alpha,Soluble Intercellular Adhesion Molecule-1,Leukotriene D4 after treatment were significantly different and the observation group It is better than the control group,which is statistically significant(P<0.05).Following the intervention,the incidence of adverse reactions in the observation group,including symptoms such as nasal dryness,discomfort in the throat,bitter taste in the mouth,and minor erosion of the nasal mucosa,was found to be 7.5%.This rate was significantly lower compared to the control group,which reported an incidence of 27.5%.The difference between the two groups was statist

关键词： Glucocorticoid Histamine Leukotriene receptor antagonist Allergic rhinitis serum inflammatory index

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