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Maternal serum lipids in Pre-Eclamptic and Normotensive Pregnant Women: A Case-Control Study

Open Journal of Obstetrics and Gynecology 2021年第11期11卷 1619-1628页

作者： Olumide Emmanuel Adewara Adeleye Niyi Ogundolire Adebayo Augustine Adeniyi Segun Murtala Ghazali Sunday Babatunde Awoyinka Idowu Adebara Olumide Mojisola Ayankunle Ayokunle Moses Olumodeji Olabisi Timothy Adeyemo Adewumi Bakare Department of Obstetrics and Gynaecology Afe Babalola University Ado-Ekiti Ekiti State Nigeria Department of Obstetrics and Gynaecology Federal Teaching Hospital Ido-Ekiti Ekiti State Nigeria Department of Chemical Pathology Afe Babalola University Ado-Ekiti Ekiti State Nigeria Department of Obstetrics and Gynaecology Lagos State University Teaching Hospital Ikeja Lagos State Nigeria

Background: preeclampsia-eclampsia is a major contributor to maternal and fetal, morbidity and mortality especially in low to middle income countries. This hypertensive disorder of pregnancy remains a disease of theor... 详细信息

Background: Preeclampsia-eclampsia is a major contributor to maternal and fetal, morbidity and mortality especially in low to middle income countries. This hypertensive disorder of pregnancy remains a disease of theories due to its unclear etiology. We evaluated for possible associations between maternal serum lipids and preeclampsia. Methods: This was a prospective case-control study that recruited 60 consenting women diagnosed with preeclampsia (cases) and 60 normotensive healthy pregnant women (controls), matched for maternal age and gestational age over an 8-month period (18th June, 2014 to 18th February, 2015) at the Federal Teaching Hospital Ido-Ekiti, Nigeria. Cases and controls were recruited using the non-probability convenience sampling. Fasting venous blood samples were collected in both cases and controls and analyzed for serum total cholesterol (TC), triglycerides (TG), high density lipoproteins (HDL) and low density lipoproteins (LDL) using Randox standard enzymatic methods. Data obtained were analyzed using SPSS version 18 to compare and test for significance using Student t-test, Chi-square, and Pearson’s correlation as the appropriate. Tests of association were determined using logistic regression models. The difference was considered significant at P Findings: The mean serum levels of TC, HDL and LDL were significantly (p < 0.001) higher in the pre-eclamptics (6.6 ± 2.9 mmol/L, 2.1 ± 1.0 mmol/L and 3.6 ± 2.6 mmol/L) th

关键词： Pregnancy and serum lipids serum lipids and preeclampsia preeclampsia

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