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Study on the correlation and predictive value of serum pregnancyassociated plasma protein A, triglyceride and serum 25-hydroxyvitamin d levels with gestational diabetes mellitus

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World Journal of Clinical Cases 2020年第5期8卷 864-873页

作者： Zhuo Ren dong Zhe Zhi Li Xin-Ping Sun Kai Yang Li Lin department of Obstetrics and Gynecology Peking University International HospitalBeijing 102206China department of Clinical Laboratory Peking University International HospitalBeijing 102206China

BACKGROUNd Gestational diabetes mellitus(GdM)is a concern due to its rapid increase in incidence in recent *** To investigate the correlation and predictive value of serum pregnancyassociated plasma protein A(PAPP-A),triglyceride(TG),and 25-hydroxyvitamin d[25-(OH)d]with GdM in early *** A total of 99 patients in early pregnancy admitted to Peking University International Hospital from November 2015 to September 2017 were included,and underwent a fasting glucose test and oral glucose tolerance test screening at 24-28 wk of *** these cases with GdM,51 were assigned to group A and the remaining 48 cases without GdM were enrolled in group *** PAPP-A,TG and 25-(OH)d in the two groups were compared and their correlation with blood sugar was *** addition,their diagnostic value in GdM was determined using receiver operating characteristic(ROC)curve *** Group A had markedly lower serum PAPP-A and 25-(OH)d levels and a significantly higher serum TG level than group B,with statistical significance(Pdentified that PAPP-A and 25-(OH)d levels were negatively correlated with fasting blood glucose(FBG)levels(r=-0.605,Pd FBG levels were positively correlated(r=0.628,Pder the curve(AUC)and optimal cut-off value of serum PAPP-A level in the diagnosis of GdM were 72.55%,82.35%,0.861 and 16.340,respectively,while the sensitivity of TG in diagnosing GdM was 86.27%,the specificity was 66.67%,the AUC was 0.813,with an optimal cut-off value of *** corresponding sensitivity,specificity,AUC and optimal cut-off value of serum 25-(OH)d were 64.71%,70.59%,0.721 and 23.140,***,multivariate logistic regression analysis revealed that FBG,vascular endothelial growth factor,Flt-1,serum PAPP-A,TG,and 25-(OH)d were related risk factors leading to GdM in *** serum PAPP-A,TG,and 25-(OH)d levels

关键词： Early pregnancy serum pregnancy-associated plasma protein A level Triglyceride serum 25-hydroxyvitamin d Gestational diabetes mellitus Oral glucose tolerance test

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