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Assessment on the Effects of Hepatitis B Prevention and Control Measures in Western China:A Comparison of Three Population-based serosurveys

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Biomedical and Environmental Sciences 2020年第10期33卷 735-744页

作者： CHEN Hui LIU Nan JI Zhao Hua PU Zhong Shu GUO Zhi Wen GAO Jie SHAO Zhong Jun LIU Yi Wen YAN Yong Ping Department of Epidemiology School of Public HealthAir Force Medical UniversityXi'an 710032ShaanxiChina Wuwei municipal Center for Disease Control and Prevention Wuwei 733000GansuChina

Objective Despite the remarkable progress in efforts to control disease spread,the nationwide elimination of hepatitis B in China is still hindered by the persistently high rate of hepatitis B virus(HBV)infection in Western *** study aimed to evaluate the strategy of hepatitis B prevention and control in Western China and identify potential areas and strategies for *** Susceptible population vaccination,health education,professional training of doctors,and other prevention and control measures have been implemented in Wuwei city since *** were obtained from three representative cross-sectional serosurveys conducted in 2010,2013,and *** serum samples were subjected to enzyme-linked immunosorbent assays to detect the following seromarkers:HBV surface antigen(HBsAg),antibody against hepatitis B surface antigen(anti-HBs),and antibody against hepatitis B core antigen(anti-HBc).Estimates of variance were determined using Taylor series linearization *** The three serosurveys revealed decreases in the prevalence of HBsAg(7.19% in 2010 vs.6.51% in 2013 vs.5.87% in 2015)and anti-HBc positivity(43.89%vs.32.87%vs.28.46%)and an increase in the prevalence of anti-HBs positivity(49.07%vs.53.66%vs.53.72%)over *** 2010 to 2015,the legally reported incidence of hepatitis B in Wuwei city decreased from 686.53/100,000 to 53.72/100,***,persistently high HBsAg-positive rates(above 5.40%)were observed among subjects aged 20–69 years old in the three serosurveys;the prevalence of HBsAg was above 1% among children younger than 10 years ***,rural subjects had higher rates of HBsAg and anti-HBc positivity than their urban counterparts(6.04%vs.4.83% and 30.26%vs.20.35%,respectively)in 2015 but had a lower rate of anti-HBs positivity(49.68 vs.55.18%).Multivariate regression analysis showed that age,urban and rural areas,and education level were the main factors affecting HBV *** Although vaccine-based preve

关键词： Hepatitis B Prevention a n d control measures serosurvey Western China

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Immunological evidence of Zika virus transmission in Thailand

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Asian Pacific Journal of Tropical Medicine 2016年第2期9卷 136-139页

作者： Nitwara Wikan Yupin Suputtamongkol Sutee Yoksan Duncan R.Smith Prasert Auewarakul Institute of Molecular Biosciences Mahidol University Faculty of Medicine Siriraj Hospital Mahidol University

Objective: To identify immunological evidence of Zika virus transmission in Thailand. Methods: To undertake a preliminary serosurvey of possible exposure to Zika virus, 21 serum samples from cohort of acute undifferentiated fever patients were examined for immunoreactivity to Zika, Dengue, Japanese encephalitis and Chikungunya envelope antigens by Western blot analysis. Results: Twenty of the 21 serum samples showed immunoreactivity to at least one of the antigens, with seven samples showing immunoreactivity to all antigens. Of particular note, two serum samples showed immunoreactivity only to Zika envelope antigen, with no immunoreactivity to other envelope antigens. Conclusions: This study presents the first evidence of Zika virus transmission in Thailand, although as yet the relationship between transmission and possible cases of Zika fever in Thailand requires further investigation.

关键词： Emerging infectious diseases serosurvey Thailand Zika virus

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