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Concomitant atypical knee gout and seronegative rheumatoid arthritis:A case report

World Journal of Clinical Cases 2024年第22期12卷 5245-5252页

作者： Zhou-Yi Chen Min-Hua Ou-Yang Shao-Wei Li Rui Ou Zhi-Huang Chen Song Wei Department of Chinese Medicine General Hospital of Southern Theater CommandGuangzhou 510010Guangdong ProvinceChina Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhou 510405Guangdong ProvinceChina The Second Clinical Medical College Guangzhou University of Chinese MedicineGuangzhou 510405Guangdong ProvinceChina Department of Gout Guangdong Hydropower HospitalGuangzhou 511340Guangdong ProvinceChina

BACKGROUND Gout and seronegative rheumatoid arthritis(SNRA)are two distinct inflammatory joint diseases whose co-occurrence is relatively infrequently *** information is available regarding the clinical management and prognosis of these combined *** SUMMARY A 57-year-old woman with a 20-year history of joint swelling,tenderness,and morning stiffness who was negative for rheumatoid factor and had a normal uric acid level was diagnosed with *** initial regimen of methotrexate,leflunomide,and celecoxib alleviated her symptoms,except for those associated with the *** symptom recurrence after medication cessation,her regimen was updated to include iguratimod,methotrexate,methylprednisolone,and folic acid,but her knee issues *** invasive needle-knife scope therapy revealed proliferating pannus and needle-shaped crystals in the knee,indicating coexistent SNRA and atypical knee *** postarthroscopic surgery to remove the synovium and urate crystals,and following a tailored regimen of methotrexate,leflunomide,celecoxib,benzbromarone,and allopurinol,her knee symptoms were significantly alleviated with no recurrence observed over a period of more than one year,indicating successful management of both *** This study reports the case of a patient concurrently afflicted with atypical gout of the knee and SNRA and underscores the significance of minimally invasive joint techniques as effective diagnostic and therapeutic tools in the field of rheumatology and immunology.

关键词： Arthroscopic debridement Minimally invasive diagnostic techniques seronegative rheumatoid arthritis Atypical knee gout Case report

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