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Serum hepatitis B virus RNA is a predictor of HBeAg seroconversion and virological response with entecavir treatment in chronic hepatitis B patients

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World Journal of Gastroenterology 2019年第6期25卷 719-728页

作者： Hao Luo Xia-Xia Zhang Li-Hua Cao Ning Tan Qian Kang Hong-Li Xi Min Yu Xiao-Yuan Xu Department of Infectious Diseases Peking University First Hospital Department of Gastroenterology Capital Medical University Beijing Tiantan Hospital Department of Infectious Diseases the Third Hospital of Qinhuangdao

BACKGROUND Characteristics of alterations of serum hepatitis B virus(HBV) RNA in different chronic hepatitis B(CHB) patients still cannot be fully explained. Whether HBV RNA can predict HBeAg seroconversion is still *** To investigate whether HBV RNA can predict virological response or HBeAg seroconversion during entecavir(ETV) treatment when HBV DNA is *** The present study evaluated 61 individuals who were diagnosed and treated with long-term ETV monotherapy at the Department of Infectious Diseases of Peking University First Hospital(China) from September 2006 to December ***, 30 treatment-naive individuals were included. Serum HBV RNA were extracted from 140 μL serum samples at two time points. Then they were reverse transcribed to cDNA with the HBV-specific primer. The product was quantified by real-time quantitative PCR(RT-PCR) using TAMARA probes. Statistical analyses were performed with IBM SPSS *** Level of serum HBV RNA at baseline was 4.15 ± 0.90 log10 copies/mL. HBV RNA levels showed no significant difference between the virological response(VR)and partial VR(PVR) groups at baseline(P = 0.940). Serum HBV RNA significantly decreased among patients who achieved a VR during ETV therapy(P seroconversion group and those with no seroconversion increased after 24 wk of treatment. Overall, HBV RNA significantly but mildly correlated to HBsAg(r =0.265, P = 0.041), and HBV RNA was not correlated to HBV DNA(r = 0.242, P =0.062). Furthermore, serum HBV RNA was an independent indicator for predicting HBeAg seroconversion and virological response. HBeAg seroconversion was more likely in CHB patients with HBV RNA levels below4.12 log10 copies/mL before *** The level of serum HBV RNA could predict HBeAg seroconversion and PVR during treatment. In the PVR group, the level of serum HBV RNA tends to be increasing.

关键词： Chronic hepatitis B Hepatitis B virus RNA Virological response HBeAg seroconversion Entecavir

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Serum hepatitis B core-related antigen as a surrogate marker of hepatitis B e antigen seroconversion in chronic hepatitis B

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World Journal of Gastroenterology 2021年第40期27卷 6927-6938页

作者： Xiu-Mei Chi Xiao-Mei Wang Zhong-Feng Wang Rui-Hong Wu Xiu-Zhu Gao Hong-Qin Xu Yan-Hua Ding Jun-Qi Niu Department of Hepatology Key Laboratory of Zoonosis ResearchMinistry EducationThe First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Phase I Clinical Trials Unit The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina

BACKGROUND Quantitative hepatitis B core-related antigen(qHBcrAg)has a better correlation with intrahepatic hepatitis B virus(HBV)covalently closed circular DNA(cccDNA)than HBV DNA or hepatitis B e antigen(HBeAg),but data are still lacking for its clinical *** The aim was to investigate serum qHBcrAg levels in patients with chronic hepatitis B and assess the correlation of serum qHBcrAg with pregenomic RNA(pgRNA),cccDNA,and HBeAg *** This study was a secondary analysis of patients who underwent percutaneous liver biopsy between July 2014 and June 2019 in two multicenter randomized controlled clinical trials of peginterferon vs nucleos(t)ide analog(NUC)-based therapy(NCT03509688 and NCT03546530).Serum qHBcrAg,pgRNA,HBV DNA,hepatitis B core antigen,HBeAg,liver cccDNA,and HBV DNA were *** correlations of serum qHBcrAg with other biomarkers were *** A total of 139 patients were *** mean qHBcrAg levels were 5.32±1.18 log10 U/mL at baseline and decreased during treatment(all Pseroconversion,with areas under the receiver operating characteristics curve of 0.788 at 24 wk and 0.825 at 48 *** HBcrAg at wk 24 and 48 was independently associated with HBeAg seroconversion[odds ratio(OR)=2.402,95%confidence interval(CI):1.314-4.391,P=0.004;OR=3.587,95%CI:1.315-9.784,P=0.013].CONCLUSION Serum HBcrAg levels were correlated with HBV virological markers and could be used to predict HBeAg seroconversion.

关键词： Hepatitis B virus Hepatitis B core antigen Hepatitis B virus DNA Detection Liver biopsy Pregenomic RNA Quantitative hepatitis B core-related antigen Receiver operating characteristic seroconversion Correlation

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Factors Associated with Antigen HBs seroconversion among Blood Donors in Ouagadougou from 2008 to 2017

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Advances in Infectious Diseases 2021年第3期11卷 278-289页

作者： Abdoul-Guaniyi Sawadogo T. Isidore Traore Salam Sawadogo Kompingnin Nebie Lucien Désiré Dahourou Juste Some Hervé Kpoda Ahmed Kabore Dahourou Honorine Arzouma Paul Yooda Bia Emile Drabo Jean-Etienne Koanda Alain Konseybo Eléonore Kafando Nicolas Meda Léon Blaise Savadogo Centre National de Transfusion Sanguine (CNTS) Ouagadougou Burkina Faso ONG Terre des hommes Lausanne Ouagadougou Burkina Faso Centre MURAZ Bobo-Dioulasso Burkina Faso Université Nazi BONI Bobo-Dioulasso Burkina Faso Université Joseph KI-ZERBO Ouagadougou Burkina Faso Institut de Recherche en Sciences de la Santé (IRSS) Ouagadougou Burkina Faso Université Norbert ZONGO Koudougou Burkina Faso

Introduction: The risk of transmission of pathogens such as hepatitis B virus threatens the safety of transfused patients especially in high endemic areas. The aim of this study was to determine the incidence and factors associated with hepatitis B virus surface antigen (HBsAg) seroconversion in blood donors at the Regional Blood Transfusion Centre of Ouagadougou. Methods: A retrospective cohort study of voluntary non-remunerated blood donors (VNRBD), was conducted from 2008 to 2017. Data on HBsAg seroconversion were collected. The Kaplan-Meier method and the Log-Rank test were used to estimate the survival curves. Cox’s regression identified the factors associated with this seroconversion. Results: Of 23,494 donors, 559 had HBsAg seroconversion. The number of donor years was 58,637.50 and the HBV incidence rate was 9.53 per 1000 donor years. The median seroconversion time was 75.73 months with extremes of 2.7 months and 107.12 months. The risk of seroconversion was 1.30 times higher among donors aged 21 to 24 years old (p = 0.007) and 2.49 times higher among those over 24 years old (p seroconversion (Hazard ratio = 1.12;p = 0.36). The risk of seroconversion decreased significantly with the number of blood donations (Hazard ratio = 0.58;p = 0.006). Conclusion: The incidence of HBsAg remains high among blood donors, which could have a negative impact on transfusion safety. The age of the blood donor was significantly associated to AgHBs seroconversion.

关键词： Time to Onset Viral Hepatitis B Blood Donors seroconversion

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HIV and seroconversion among Pregnant Women at the University Hospital of Mother and Child in Chad

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Journal of Biosciences and Medicines 2023年第1期11卷 106-115页

作者： Fissou Henry Yandai Ali Mahamat Moussa Mahamat Ali Bolti Djidda Abakar Oumar Hissene Adanaou Khadidja Attimer Hamit Mahamat Alio Kuan Abdoulaye Traore Nicolas Barro Institut de Recherche en Elevage pour le Développement (IRED) N’Djamena Tchad Centre Hospitalier Universitaire la Renaissance (CHU-R) N’Djamena Tchad Laboratoire de Biologie Moléculaire d’Epidémiologie et de Surveillance des Bactéries et Virus Transmissibles par les Aliments (LaBESTA) Université Joseph KI-ZERBO Ouagadougou Burkina Faso Faculté des Sciences de la Santé Humaine (FSSH) N’Djamena Tchad Laboratoire de Sciences de la Vie et de la Terre (LaSVT) Université Norbert ZONGO Koudougou Burkina Faso

Background: HIV in pregnant women presented a risk of transmission to newborns. This study was to determine HIV prevalence among pregnant women in the birthing rooms and give antiretrovirals to women infected and their newborns. Methods: A preliminary study was conducted from 2013 to 2015 at the Mother and Child Hospital. Pregnant women were counseled and tested for HIV-antibody according to the national algorithm using Determine HIV 1 & 2 and Immunocomb II Bispot HIV1 & 2. The women screened HIV-negative during the prenatal consultation and who accepted a second test were screened in the birth room. The data collected were processed using the Access Microsoft office 16 and SPSS software version 18. Results: A total of 6080 pregnant women were tested before and in the birth room. Of these, 5943 (97.4%) were detected as HIV-negative and 159 (2.6%) were HIV-positive. Of the 5943 with HIV-negative status, 1333 accepted the second test in the birth room, 10 of which have become HIV-positive. The rate of seroconversions was 0.75%. Conclusion: This study determined the prevalence of HIV in pregnant women. The result reveals the importance and necessity of repeating the screening test in the birth room because of the possibility of seroconversion or new infection during pregnancy.

关键词： HIV Prevalence seroconversion Pregnancy Chad

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Liver Histopathological Features Influencing HBeAg seroconversion in Patients with HBeAg-positive Chronic Hepatitis B Treated with Pegylated Interferon α

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国际感染病学（电子版） 2014年第1期3卷 10-15页

作者： Yao-ren Hu Hua-dong Yan Guo-sheng Gao Cheng-liang Zhu Ji-fang Cheng Ningbo No.2 Hospital Renmin Hospital of Wuhan University The First Affiliated Hospital of Zhejiang University

Objective To investigate the efficiency of pegylated interferon α therapy for patients with HBe Ag-positive chronic hepatitis B(CHB) and explore whether liver histopathological features and other factors might influence HBe Ag *** Total of 80 HBe Ag-positive CHB patients who received liver puncture were treated with pegylated interferon α once a week for 48 weeks. The rate of HBe Ag seroconversion was determined after therapy, and the factors influencing HBe Ag seroconversion were *** The rate of HBe Ag seroconversion was 30.00% at the end of treatment. The rate of HBe Ag seroconversion gradually increased with the elevation of liver inflammatory activity(χ2 = 9.170, P = 0.027). But liver fibrosis has little correlation with the rate of HBeA g seroconversion(χ2 = 5.917, P = 0.116). Except HBeA g, other baseline indexes including gender, age, serum ALT and serum HBV DNA 1evels had no statistical difference between the patients with HBe Ag seroconversion and the patients without HBe Ag seroconversion. By binary logistic regression analysis, liver inflammation and HBeA g were influencing factors for HBeA g seroconversion. Conclusions Pegylated interferon α therapy induces a higher rate of HBeA g seroconversion in HBeA g-positive chronic hepatitis B patients with severe liver inflammation, so the liver biopsies should be performed in time.

关键词： Chronic hepatitis B Pegylated interferon α Hepatitis B e antigen seroconversion

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Mutations of pre-core and basal core promoter before and after hepatitis B e antigen seroconversion

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World Journal of Gastroenterology 2015年第2期21卷 541-548页

作者： Nozomi Kamijo Akihiro Matsumoto Takeji Umemura Soichiro Shibata Yuki Ichikawa Takefumi Kimura Michiharu Komatsu Eiji Tanaka Department of Medicine Shinshu University School of MedicineMatsumoto 390-8621Japan

AIM: To investigate the role of pre-core and basal core promoter(BCP) mutations before and after hepatitis Be antigen(HBe Ag) ***: The proportion of pre-core(G1896A) and basal core promoter(A1762T and G1764A) mutant viruses and serum levels of hepatitis B virus(HBV) DNA, hepatitis B surface antigen(HBs Ag), and HB core-related antigen were analyzed in chronic hepatitis B patients before and after HBe Ag seroconversion(n = 25), in those who were persistently HBe Ag positive(n = 18), and in those who were persistently anti-HBe positive(n = 43). All patients were infected with HBV genotype C and were followed for a median of 9 ***: Although the pre-core mutant became predominant(24% to 65%, P = 0.022) in the HBe Ag seroconversion group during follow-up, the proportion of the basal core promoter mutation did not change. Median HBV viral markers were significantly higher in patients without the mutations in an HBe Ag positive status(HBV DNA: P = 0.003; HBs Ag: P seroconversion in patients with HBV infection.

关键词： seroconversion Hepatitis B core-related antigen Pr

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HIV seroconversion manifesting as Guillian-Barre syndrome

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Chinese Medical Journal 2014年第2期127卷 396-396页

作者： Ankur Nandan Varshney Ravi Anand Annesh Bhattacharjee Pratibha Prasad Nilesh Kumar N. K. Singh Department of General Medicine Institute of Medical Sciences Banaras Hindu University Varanasi-221005 Uttar Pradesh India

To the editor： Human immunodeficiency vires （HIV） infection is an epidemic of modem era. Primary HIV infection usually presents as fever, fatigue, lymphadenopathy, myalgia, nausea and diarrhoea. Neurological symptoms may present during primary infection in 9% of patients usually as aseptic meningitis or opportunistic infections. The occurrence of Guillian-Barre syndrome （GBS） during seroconversion of HIV is rare.

关键词： seroconversion syndrome nausea

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Characterized CD8+ T cell Repertoire Predicts seroconversion of Hepatitis B Virus e Antigen in Chronic Hepatitis B patients

Characterized CD8+ T cell Repertoire Predicts Seroconversion...

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第十一届全国免疫学学术大会

作者： Xiaoyun Shang Institute of Immunology PLAThird Military Medical University

Background: Immunotherapy based on the adoptive transfer of naturally occurring or gene-engineered T cells for cancer or chronic infection is an emerging field that shows promise recently. However, the major challenge currently facing the field is to select appropriate protective T cell clonotypes with more functional anti-viral capacity but less tissue-injury side effect. Objective: of this study was to use high-throughput TCR sequencing to identify protective clonotypes with effective immune control of chronic hepatitis B virus *** and Findings: We performed a prospective cohort study among 75 unrelated CHB patients in China. Firstly, by deciphering and comparing the global peripheral CD8 T cell repertoire using high-throughput sequencing, we defined a population of clonotypes(A) related to the favorable outcome, which were further demonstrated to be a favorable prog-nosis marker in predicting its clinical outcome in the initial stage. Secondly, another population of CD8 T cell clonotypes(B), which exists in both healthy controls and patients, predicted impending elevation of alanine aminotransferase. Thirdly, these findings and the state-of-the-art TCR repertoire analysis strategy were validated in an additional independent cohort of patients in another hospital. Lastly, based on the clonotypes in those patients with favorable outcome, we created a database including several clusters of protective anti-HBV CD8 T cell clonotypes, which might be a reasonable target for therapeutic vaccine development or adoptive cell transfer ***: By deciphering and comparing the TCRβ repertoire profile between controllers and progressors, protective and harmful clonotypes were identified and proved to be a good prognosis marker of clinical outcomes. To our knowledge, our findings provide the first evidence that effective immune control in CHB is mediated by certain characterized protective T cell clonotypes. These identified clonotypes provide a ratio

关键词： Hepatitis B T cell Repertoire seroconversion

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seroconversion of Hepatitis B and Hepatitis C among Hemodialysis Patients,Baghdad,2015

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Journal of Health Science 2019年第1期7卷 23-28页

作者： Riyadh Mraweh Ibrahim Bushra Jabbar Hashem Division of Total Quality Management and Institutional Development Directorate of Public Health. Ministry of Health Baghdad 10047 Republic of Iraq Training and Development Division Baghdad Al-rusafa directorate Republic of Iraq

Hepatitis C&B still the major problem in hemodialysis patients and the challenge continues in dialysis centers to prevent spread among patients and workers,the worldwide reported incidence of anti-HC antibody in dialysis center was range from 10.5%-24% yearly and the prevalence range 5-85%.Also,HBs-antigen had the same problem but with less incidence and *** the purpose of evaluating the seroprevalence and seroconversion of anti-HC antibody and HBs-antigen in Haemodialysis centers at Baghdad required action a retrospective incidence study from Nov.2015 to Jan.2016 on maintenance HD patients at hemodialysis centers in Al-kindi,Al-Karama and Baghdad *** data obtained from patients records of hospitals and we relied on laboratory test results for ELISA to determine the seroconversion and seroprevalence of anti-HC-antibody and *** study found the total prevalence of seropositive anti-HCV antibody in three centers were 251(28%),the seropositive patients of HBs-Ag were 14(2%)While the total seroconversion was 196(21%)anti-HCV antibody and for HBs-Ag 4(0.4%);so there was serious risk of nosocomial infection particularly for hepatitis C in the hemodialysis centers in Baghdad and AL-kindi while the problem with HBV was under control at same time The differences of seroconversion and seroprevalence of anti-HC antibody and HBs-antigen between the hospitals in the study may indicate to the level of infection control was applied in hospital.

关键词： seroconversion seroprevalence hemodialysis hepatitis

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New perspective on the natural course of chronic HBV infection

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Frontiers of Medicine 2014年第2期8卷 129-134页

作者： Yong-Yuan Zhang Ke-Qin Hu Zhongping Duan HB Vtech LLC 13901 Lullaby RD Germantown MD 20874 USA Division of Gastroenterology and Hepatology University of California Irvine School of Medicine Orange CA 92868 USA You An Hospital Capital Medical University Beijing 100069 China

Chronic hepatitis B virus （HBV） infection is a significant threat to public health and an enormous burden on society. Mechanisms responsible for chronic HBV infection remain poorly understood. A better understanding of the natural course of chronic HBV infection may shed new light on the mechanisms underlying this disease and help in designing new antiviral strategies. Natural course of chronic HBV infection is conventionally viewed as an uninterrupted process that is usually marked by HBV e antigen （HBeAg） seroconversion or characterized by different phases associated with assumed host responses to HBV infection. However, none of these descriptions captures or highlights the core events that determine the natural course of chronic HBV infection. In this review, we briefly present the current knowledge on this subject and explain the significance and implication of events that occur during infection. A pre-core mutant becomes predominant in the viral population following elimination of the wild-type virus in duck hepatitis B virus-chronically infected animals. The coupled events in which first there is viral clearance that clears wild-type virus and then there is the reinfection of wild-type virus cleared livers with mutant virus are highly relevant to understanding of the natural course of chronic HBV infection under both treated and untreated conditions. In our new perspective, a general natural course of chronic HBV infection comprises cycles of viral clearance and reinfection, and such cycles prolong the chronic HBV infection course. Reviewing published data on the natural course of chronic HBV infection can reduce the possibility of missing important points in the initial data interpretation.

关键词： hepatitis B virus chronic HBV infection natural course hepatitis B seroconversion

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