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Repeatedly elevatedγ-glutamyltransferase levels are associated with an increased incidence of digestive cancers:A population-based cohort study

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World Journal of Gastroenterology 2021年第2期27卷 176-188页

作者： Chang-Hoon Lee Kyungdo Han Da Hye Kim Min-Sun Kwak Department of Internal Medicine Seoul National University HospitalSeoul 03080South Korea Department of Statistics and Actuarial Science Soongsil UniversitySeoul 06978South Korea Department of Biostatistics College of MedicineCatholic University of KoreaSeoul 06591South Korea Department of Internal Medicine Healthcare Research InstituteHealthcare System Gangnam CenterSeoul National University HospitalSeoul 06236South Korea

BACKGROUND The association between elevatedγ-glutamyltransferase(GGT)at a certain point and incident cancer has been suggested;however,no study has evaluated the association between repeatedly elevated GGT and cancer *** To investigate the effects of repeatedly elevated GGT on the incidence of digestive *** Participants who had undergone health screening from 2009 to 2012 and 4 consecutive previous examinations were *** points were calculated as the number of times participants met the criteria of quartile 4 of GGT in four serial measurements(0-4 points).Multivariable Cox proportional hazard regression models were *** In total,3559109 participants were included;among them,43574 digestive cancers developed during a median of 6.8 years of *** incidence of total digestive cancers increased in a dose-response manner in men[adjusted hazard ratio(aHR)compared with those with 0 GGT points=1.28 and 95%confidence interval(CI)=1.24-1.33 in those with 1 point;aHR=1.40 and 95%CI=1.35-1.46 in those with 2 points;aHR=1.52 and 95%CI=1.46-1.58 in those with 3 points;aHR=1.88 and 95%CI=1.83-1.94 in those with 4 points;P for trend<0.001].This trend was more prominent in men than in women and those with healthy habits(no smoking,no alcohol consumption,and a low body mass index)than in those with unhealthy *** Repeatedly elevated GGT levels were associated with an increased risk of incident digestive cancer in a dose-responsive manner,particularly in men and those with healthy *** GGT measurements may be a good biomarker of incident digestive cancer and could help physicians identify high-risk populations.

关键词： Gamma-glutamyltransferase Cancer Digestive organ serial exam Incident cancer Biomarker

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