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The effect of acupuncture at Jǐngjiājǐ(颈夹脊) on the repair and regeneration of cochlear hair cells of rats with sensorineural deafness

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World Journal of Acupuncture-Moxibustion 2018年第1期28卷 55-58,I0008页

作者： Li ZHONG-TAI Cui LI-NA Department of Acupuncture-Moxibustion Yanbian University Hospital Yanji 133000 Jilin Province China

Objective： To observe the effect of acupuncture at Jǐngjiājǐ（颈夹脊）on the repair and regeneration of cochlear hair cells of guinea pigs with sensorineural ***： Sixty healthy guinea pigs were selected, 20 guinea pigs were randomly assigned to the normal control group（group A）, and other guinea pigs were randomly divided into model control group（group B） and acupuncture treatment group（group C） after injection with gentamicin sulfate in order to induce deafness. No intervention was given to the guinea pigs in group A and group B, and acupuncture at Jǐngjiājǐ was given to the guinea pigs in group C for 30 days. ABR threshold, DPOAE amplitudes and hair cells counting of guinea pigs in each group were recorded after intervention for 30 ***： After intervention for 30 days, ABR threshold in group C was significantly lower than that in group B（38.46 ±7.36 vs 82.94 ±6.47, P〈0.01）. and the DPOAE amplitudes in group C were obviously higher than that in group B（28.06 ±5.64 vs 25.23 ±5.38, P〈0.01）. The number of cochlear hair cells in group C increased significantly, over 50% of the hair cells survived, accounting for 66.67% of the observation cases. The number of cochlear hair cells in the 3 rd and 4 th gyri was close to the normal level, and plenty of proliferous sustentacular cells can be seen. Compared with group B, the number of cochlear outer hair cells in each gyrus in group C significantly increased（36.76 ±1.97 vs 28.59±2.24, P〈0.01）, indicating that acupuncture at Jǐngjiajǐ can promote the repair and regeneration of cochlear hair ***： Acupuncture at Jǐngjiajǐ can promote the repair and regeneration of cochlear hair cells, thus improving the hearing of guinea pigs with deafness.

关键词： sensorineural deafness Jingjiaji ABR DPOAE Hair cell

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Clinical and Experimental Observation on Treatment of sensorineural deafness with Bushen Conger Tablet (补肾聪耳片)

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Chinese Journal of Integrative Medicine 1998年第2期4卷 103-106页

作者：林文森石志兴马恩明陈洁伍孝先周文洛袁洪达 Department of Otorhinolaryngology Nankai Hospital 300100 Tianjin Institute of Acute Abdomen of Integrated TCM-WM Tianjin

Objective: To observe the effect of Bushen Conger （BSCE） tablet, a pure Chinese herbal medicine for reinforcing Kidney, removing blood stasis and opening apertures, in treating sensorineural deafness. Methods: Three hundred and ten patients were treated by BSCE tablet and the effects were observed. At the same time the effects of BSCE tablet on hearing, SOD, LPO, etc. were also assayed in guinea pigs. Results: The clinical total effective rate of BSCE tablet was 71.9 %. Animal experiment proved that the drug was effective in preventing and treating toxic deafness induced by aminoglycoside antibiotics. Conclusion: BSCE tablet could cure sensorineural deafness through adjusting the cochlear cyclic neucleotides as well as its SOD level, reducing the LPO level, and raising the thyroid and sexual glandular functions.

关键词： Bushen Conger tablet sensorineural deafness toxic deafness model

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HDR syndrome presented with nephrotic syndrome in a Chinese boy: A case report

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World Journal of Clinical Cases 2024年第27期12卷 6111-6116页

作者： Li-Juan Ma Wu Yang Hong-Wen Zhang Department of Pediatrics Peking University First Hospital Ningxia Women and Children’s HospitalYinchuan 750001Ningxia Hui Autonomous RegionChina Department of Pediatric Peking University First HospitalBeijing 100034China

BACKGROUND HDR syndrome is a rare genetic disease caused by variants in the GATA3 gene and is phenotypically defined by the triad of hypoparathyroidism(H),deafness(D),and renal disease(R).Renal disorders of HDR are mainly developmental ab-normalities,although renal functional abnormalities can also be ***-phrotic syndrome or nephrotic-level proteinuria is rare in HDR ***,we report a Chinese infant with HDR syndrome who presented with early-onset nephrotic *** suggest that variants in the GATA3 gene might be asso-ciated with nephrotic syndrome.(***235 Leu),in exon 3 of the GATA3 *** We report an infant with HDR syndrome who presented with early-onset nephrotic syndrome in *** suggest that variants in the GATA3 gene might be associated with infant-onset nephrotic syndrome.

关键词： HDR syndrome sensorineural deafness Nephrotic syndrome China Case report

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