检索结果-南通市图书馆

Structural changes in pyramidal cell dendrites and synapses in the unaffected side of the sensorimotor cortex following transcranial magnetic stimulation and rehabilitation training in a rat model of focal cerebral infarct

引用

Neural Regeneration Research 2011年第9期6卷 676-680页

作者： Chuanyu Liu Surong Zhou Xuwen Sun Zhuli Liu Hongliang Wu Yuanwu Mei Department of Neurology the Affiliated Yantai Yuhuangding Hospital of Qingdao University Medical College Yantai 264000 Shandong Province China Department of Neurology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 Hubei Province China

Very little is known about the effects of transcranial magnetic stimulation and rehabilitation training on pyramidal cell dendrites and synapses of the contralateral, unaffected sensorimotor cortex in a rat model of focal cerebral infarct. The present study was designed to explore the mechanisms underlying improved motor function via transcranial magnetic stimulation and rehabilitation training following cerebral infarction. Results showed that rehabilitation training or transcranial magnetic stimulation alone reduced neurological impairment in rats following cerebral infarction, as well as significantly increased synaptic curvatures and post-synaptic density in the non-injured cerebral hemisphere sensorimotor cortex and narrowed the synapse cleft width. In addition, the percentage of perforated synapses increased. The combination of transcranial magnetic stimulation and rehabilitation resulted in significantly increased total dendritic length, dendritic branching points, and dendritic density in layer V pyramidal cells of the non-injured cerebral hemisphere motor cortex. These results demonstrated that transcranial magnetic stimulation and rehabilitation training altered structural parameters of pyramidal cell dendrites and synapses in the non-injured cerebral hemisphere sensorimotor cortex, thereby improving the ability to compensate for neurological functions in rats following cerebral infarction.

关键词： cerebral infarction transcranial magnetic stimulation rehabilitation training sensorimotor cortex pyramidal cell dendrites synapse neural regeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Deletion of Krüppel-like factor-4 promotes axonal regeneration in mammals

引用

Neural Regeneration Research 2021年第1期16卷 166-171页

作者： Jin-Hui Xu Xu-Zhen Qin Hao-Nan Zhang Yan-Xia Ma Shi-Bin Qi Hong-Cheng Zhang Jin-Jin Ma Xin-Ya Fu Ji-Le Xie Saijilafu Department of Orthopedics The First Affiliated Hospital of Soochow UniversityOrthopedic InstituteSoochow UniversitySuzhouJiangsu ProvinceChina

Axonal regeneration plays an important role in functional recovery after nervous system ***,after axonal injury in mammals,regeneration is often *** deletion of Krüppel-like factor-4(Klf4)has been shown to promote axonal regeneration in retinal ganglion ***,the effects of Klf4 deletion on the corticospinal tract and peripheral nervous system are *** this study,using a mouse model of sciatic nerve injury,we show that the expression of Klf4 in dorsal root ganglion sensory neurons was significantly reduced after peripheral axotomy,suggesting that the regeneration of the sciatic nerve is associated with *** vitro,dorsal root ganglion sensory neurons with Klf4 knockout exhibited significantly enhanced axonal ***,the regeneration of the sciatic nerve was enhanced in vivo following Klf4 ***,AAV-Cre virus was used to knockout the Klf4 gene in the *** deletion of Klf4 enhanced regeneration of the corticospinal tract in mice with spinal cord ***,our findings suggest that regulating KLF4 activity in neurons is a potential strategy for promoting axonal regeneration and functional recovery after nervous system *** study was approved by the Animal Ethics Committee at Soochow University,China(approval ***20200316A01).

关键词： axonal regeneration corticospinal tract dorsal root ganglion Klf4 peripheral nervous system sciatic nerve crush sensorimotor cortex spinal cord crushl

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Surface-based map plasticity of brain regions related to sensory motor and pain information processing after osteonecrosis of the femoral head

引用

Neural Regeneration Research 2022年第4期17卷 806-811页

作者： Jie Ma Xu-Yun Hua Mou-Xiong Zheng Jia-Jia Wu Bei-Bei Huo Xiang-Xin Xing Sheng-Yi Feng Bo Li Jian-Guang Xu School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Traumatology and Orthopedics Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center) Tongji UniversityShanghaiChina Center of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina

Pain is one of the manifestations of hip disorder and has been proven to lead to the remodeling of somatotopic map plasticity in the ***,most studies are volume-based which may lead to inaccurate anatomical positioning of functional *** methods that work on the cortical surface may be more sensitive than those using the full brain volume and thus be more suitable for map plasticity *** this prospective cross-sectional study performed in Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,China,20 patients with osteonecrosis of the femoral head(12 males and 8 females,aged 56.80±13.60 years)and 20 healthy controls(9 males and 11 females,aged 54.56±10.23 years)were included in this *** of resting-state functional magnetic resonance imaging were *** results revealed that compared with healthy controls,compared with the healthy controls,patients with osteonecrosis of the femoral head(ONFH)showed significantly increased surface-based regional homogeneity(Re Ho)in areas distributed mainly in the left dorsolateral prefrontal cortex,frontal eye field,right frontal eye field,and the premotor cortex and decreased surface-based Re Ho in the right primary motor cortex and primary sensory *** showing significant differences in surfacebased Re Ho values between the healthy controls and patients with ONFH were defined as the regions of ***-based functional connectivity was performed to investigate interregional functional *** the areas with decreased surface-based Re Ho in the frontal eye field and right premotor cortex were used as the regions of interest,compared with the healthy controls,the patients with ONFH displayed increased functional connectivity in the right middle frontal cortex and right inferior parietal cortex and decreased functional connectivity in the right precentral cortex and right middle occipital ***

关键词： cortical thickness functional connectivity hip disorder osteonecrosis of the femoral head Re Ho sensorimotor cortex surface-based map plasticity volume of subcortical gray matter nuclei

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nerve root magnetic stimulation improves locomotor function following spinal cord injury with electrophysiological improvements and cortical synaptic reconstruction

引用

Neural Regeneration Research 2022年第9期17卷 2036-2042页

作者： Ya Zheng Dan Zhao Dong-Dong Xue Ye-Ran Mao Ling-Yun Cao Ye Zhang Guang-Yue Zhu Qi Yang Dong-Sheng Xu Department of Rehabilitation Tongji HospitalSchool of MedicineTongji UniversityShanghaiChina Department of Hepatobiliary Surgery Hebei General HospitalShijiazhuangHebei ProvinceChina Department of Rehabilitation Baoshan BranchShuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghaiChina School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Rehabilitation The Sixth People’s Hospital Affiliated to Shanghai Jiao Tong UniversityShanghaiChina Department of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghaiChina Rehabilitation Engineering Research Center for Integrated Traditional Chinese and Western Medicine Ministry of EducationShanghaiChina Department of Rehabilitation Medicine Ruijin Hospital Affiliated to Shanghai Jiao Tong UniversityShanghaiChina

Following a spinal cord injury,there are usually a number of neural pathways that remain intact in the spinal *** residual nerve fibers are important,as they could be used to reconstruct the neural circuits that enable motor *** group previously designed a novel magnetic stimulation protocol,targeting the motor cortex and the spinal nerve roots,that led to significant improvements in locomotor function in patients with a chronic incomplete spinal cord ***,we investigated how nerve root magnetic stimulation contributes to improved locomotor function using a rat model of spinal cord *** underwent surgery to clamp the spinal cord at T10;three days later,the rats were treated with repetitive magnetic stimulation(5 Hz,25 pulses/train,20 pulse trains)targeting the nerve roots at the L5-L6 *** treatment was repeated five times a week over a period of three *** found that the nerve root magnetic stimulation improved the locomotor function and enhanced nerve conduction in the injured spinal *** addition,the nerve root magnetic stimulation promoted the recovery of synaptic ultrastructure in the sensorimotor ***,the results suggest that nerve root magnetic stimulation may be an effective,noninvasive method for mobilizing the residual spinal cord pathways to promote the recovery of locomotor function.

关键词： evoked potentials H-reflex motor activity nerve conduction neural plasticity rehabilitation sensorimotor cortex spinal cord injury synapses transcranial magnetic stimulation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Global Multiregional Proteomic Map of the Human Cerebral cortex

引用

Genomics, Proteomics & Bioinformatics 2022年第4期20卷 614-632页

作者： Zhengguang Guo Chen Shao Yang Zhang Wenying Qiu Wenting Li Weimin Zhu Qian Yang Yin Huang Lili Pan Yuepan Dong Haidan Sun Xiaoping Xiao Wei Sun Chao Ma Liwei Zhang Core Facility of Instrument Institute of Basic Medical SciencesChinese Academy of Medical SciencesSchool of Basic MedicinePeking Union Medical CollegeBeijing 100005China State Key Laboratory of Proteomics Beijing Proteome Research CenterNational Center for Protein Sciences(Beijing)Beijing Institute of LifeomicsBeijing 102206China Department of Neurosurgery China National Clinical Research Center for Neurological DiseasesBeijing Tiantan HospitalCapital Medical UniversityBeijing 100050China Department of Human Anatomy Histologyand EmbryologyInstitute of Basic Medical SciencesNeuroscience CenterChinese Academy of Medical SciencesSchool of Basic MedicinePeking Union Medical CollegeBeijing 100005China

The Brodmann area(BA)-based map is one of the most widely used cortical maps for studies of human brain functions and in clinical practice;however,the molecular architecture of BAs remains *** present study provided a global multiregional proteomic map of the human cerebral cortex by analyzing 29 *** 29 BAs were grouped into 6 clusters based on similarities in proteomic patterns:the motor and sensory cluster,vision cluster,auditory and Broca’s area cluster,Wernicke’s area cluster,cingulate cortex cluster,and heterogeneous function *** identified 474 cluster-specific and 134 BA-specific signature proteins whose functions are closely associated with specialized functions and disease vulnerability of the corresponding cluster or *** findings of the present study could provide explanations for the functional connections between the anterior cingulate cortex and sensorimotor cortex and for anxiety-related function in the sensorimotor *** brain transcriptome and proteome comparison indicates that they both could reflect the function of cerebral cortex,but show different *** proteomic data are publicly available at the Human Brain Proteome Atlas(***).Our results may enhance our understanding of the molecular basis of brain functions and provide an important resource to support human brain research.

关键词： Brodmann area Proteomics Cerebral cortex Cingulate cortex sensorimotor cortex

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Detection of Ca^(2+)-dependent acid phosphatase activity identifies neuronal integrity in damaged rat central nervous system after application of bacterial melanin

引用

Neural Regeneration Research 2016年第7期11卷 1147-1152页

作者： Tigran R. Petrosyan Anna S. Ter-Markosyan Anna S. Hovsepyan Yerevan State Medical University YerevanArmenia SPC"Armbiotechnology"SNPO NAS RA YerevanArmenia

The study aims to confirm the neuroregenerative effects of bacterial melanin （BM） on central nervous system injury using a special staining method based on the detection of Ca^2＋-dependent acid phosphatase activity. Twenty-four rats were randomly assigned to undergo either unilateral destruction of sensorimotor cortex （group I; n = 12） or unilateral rubrospinal tract transection at the cervical level （C3-4）（group II; n = 12）. In each group, six rats were randomly selected after surgery to undergo intramuscular injection of BM solution （BM subgroup） and the remaining six rats were intramuscularly in）ected with saline （saline subgroup）. Neurological testing confirmed that BM accelerated the recovery of motor function in rats from both BM and saline subgroups. Two months after surgery, Ca^2＋-dependent acid phosphatase activity detection in combination with Chilingarian＇s calcium adenoside triphosphate method revealed that BM stimulated the sprouting of fibers and dilated the capillaries in the brain and spinal cord. These results suggest that BM can promote the recovery of motor function of rats with central nervous system injury; and detection of Ca^2＋-dependent acid phosphatase activity is a fast and easy method used to study the regeneration-promoting effects of BM on the injured central nervous system.

关键词： nerve regeneration bacterial melanin histochemical analysis rubrospinal tract sensorimotor cortex Ca^2+-dependent acid phosphatase activity rats neural regeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：