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Assessment of immune responses and intestinal flora in BALB/c mice model of wheat food allergy via different sensitization methods

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Food Science and Human Wellness 2023年第3期12卷 871-881页

作者： Chenglong Liu Chen Chen Xingyu Yan Shimin Gu Xin Jia Wenhui Fu Xiao Meng Wentong Xue College of Food Science and Nutritional Engineering China Agricultural UniversityBeijing 100083China

Increasing incidences showed that food allergies have attracted more and more attention from ***/c mice were sensitized with wheat gluten combined with aluminum hydroxide adjuvant via intraperitoneal injection,transdermal sensitization,and oral gavage sensitization *** showed that all the three sensitization methods could induce allergic symptoms;increase the serum antibody(total immunoglobulin E(IgE),specific IgE,IgG,IgA)and histamine content;promote the secretion of Th2 cytokines(interleukin(IL)-4,IL-5,IL-13)and inflammatory factors(IL-6,IL-17 A,IL-10);and inhibit the production of Th1 cytokines(IFN-γ,IL-2).However,the allergic symptoms of mice sensitized by intraperitoneal injection were the most obvious among the three *** level of serum antibodies in intraperitoneal injection group was significantly higher than ***,16 S rRNA sequencing technology was used to analyze the intestinal flora of *** results showed that the abundance of Firmicutes in the wheat protein sensitized group was lower than that in the normal group,while the abundance of Bacteroidetes was higher,and Lactobacillus was the difference marker in normal *** species diversity analysis showed that the species richness and diversity of intestinal flora in mice were decreased,the difference between mice induced by intraperitoneal injection and normal control group mice was the most *** together,these results show that among three sensitization methods used to build a mouse model with aluminum hydroxide as adjuvant,intraperitoneal injection is the comparably best way to build a mouse sensitization mode.

关键词： Allergy Wheat gluten BALB/c mice sensitization methods Intestinal flora

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