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A new self-emulsifying formulation of mefenamic acid with enhanced drug dissolution

Asian Journal of Pharmaceutical Sciences 2015年第2期10卷 121-127页

作者： Pornsak Sriamornsak Sontaya Limmatvapirat Suchada Piriyaprasarth Punyanutch Mansukmanee Zongkang Huang Department of Pharmaceutical Technology Faculty of PharmacySilpakorn UniversityNakhon Pathom 73000Thailand Pharmaceutical Biopolymer Group(PBiG) Faculty of PharmacySilpakorn UniversityNakhon Pathom 73000Thailand

To enhance the dissolution of poorly soluble mefenamic acid,self-emulsifying formulation(SEF),composing of oil,surfactant and co-surfactant,was *** the oils and surfactants studied,Imwitor■ 742,Tween■ 60,Cremophore■ EL and Transcutol■ HP were selected as they showed maximal solubility to mefenamic *** ternary phase diagram was constructed to find optimal concentration that provided the highest drug *** droplet size after dispersion and drug dissolution of selected formulations were *** results showed that the formulation containing Imwitor■ 742,Tween■ 60 and Transcutol■ HP(10:30:60)can encapsulate high amount of mefenamic *** dissolution study demonstrated that,in the medium containing surfactant,nearly 100% of mefenamic acid were dissolved from SEF within 5 min while 80% of drugs were dissolved from the commercial product in 45 *** phosphate buffer(without surfactant),80% of drug were dissolved from the developed SEF within 5 min while only about 13% of drug were dissolved in 45 min,from the commercial *** results suggested that the SEF can enhance the dissolution of poorly soluble drug and has a potential to enhance drug absorption and improve bioavailability of drug.

关键词： self-emulsifying formulation Poorly water-soluble drug Mefenamic acid Drug dissolution

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