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Chinese Journal of Cancer 2016年第3期35卷 120-125页

作者： Shu‑Xiong Zeng Xin Lu Wei‑Dong Xu Zhen‑Sheng Zhang Hai‑Hang Li Ying‑Hao Sun Chuan‑Liang Xu Department of Urology Changhai HospitalSecond Military Medical UniversityShanghaiP.R.China Department of Burns Changhai HospitalSecond Military Medical UniversityShanghaiP.R.China.

segmental ureterectomy is less invasive than radical nephroureterectomy and results in nephron preservation and satisfactory tumor *** study was to determine the feasibility of segmental ureteroileal conduit resection(SUICR) for patients with distal upper urinary tract recurrence of bladder cancer following radical *** patients with high-grade distal upper urinary tract recurrence underwent SUICR 15-108 months after radical *** surgical technique details of SUICR,operative results,and follow-up outcomes are *** median operation time was 280 min,and estimated blood loss was less than 100 ml One patient suffered from ileus 5 days after surgery and was managed *** evaluation showed high-grade stages pTa-pT1 diseases for these patients,and ureteral margins were all *** patient suffered from tumor recurrence,with a median follow-up of 39 *** preserved the ipsilateral renal unit and conformed to oncological principles during *** oncological outcome was satisfactory for these properly selected *** technique provides a valid alternative to nephroureterectomy for patients with imperative indications and high-grade upper urinary tract recurrence of bladder cancer following radical cystectomy.

关键词： Cystectomy, Urothelial carcinoma, Upper urinary tract recurrence, segmental resection

Self-centring segmental retaining walls—A new construction system for retaining walls

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Frontiers of Structural and Civil Engineering 2021年第4期15卷 980-1000页

作者： Mehdi JAVADI Reza HASSANLI Md Mizanur RAHMAN Md Rajibul KARIM UniSA STEM University of South AustraliaMawson Lakes5095Australia

This paper reports on an experimental study on a new self-centring retaining wall *** post-tensioned segmental retaining walls(PSRWs)were experimentally *** of the walls was constructed using seven T-shaped concrete segments with a dry *** walls were tested under incrementally increasing cyclic lateral *** effect of the wall height,levels of post-tensioning(PT)force,and bonded versus unbonded condition of PT reinforcement on the structural behavior of the PSRWs was *** results showed that such PSRWs are structurally adequate for water retaining *** to the results,increasing the wall height decreases initial strength but increases the deformation capacity of the *** larger deformation capacity and ductility of PSRW make it a suitable structural system for fluctuating loads or deformation,e.g.,*** was also found that increasing the PT force increases the wall’s stiffness;however,reduces its *** residual drift and the extent of damage of the unbonded PSRWs were significantly smaller than those of the bonded *** suggest that this newly developed self-centring retaining wall can be a suitable structural system to retain lateral *** to its unique deformation capacity and self-centring behavior,it can potentially be used for seawall application.

关键词： retaining wall segmental precast concrete unbonded post-tensioning water retaining wall seawall

segmental colitis associated diverticulosis syndrome

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World Journal of Gastroenterology 2016年第36期22卷 8067-8069页

作者： Hugh J Freeman Department of Medicine(Gastroenterology) University of British Columbia

segmental colitis associated diverticulosis(SCAD) has become increasingly appreciated as a form of inflammatory disease of the colon. Several features suggest that SCAD is a distinct disorder. SCAD tends to develop almost exclusively in older adults, predominately, but not exclusively, males. The inflammatory process occurs mainly in the sigmoid colon, and usually remains localized to this region of the colon alone. SCAD most often presents with rectal bleeding and subsequent endoscopic visualization reveals a well localized process with non-specific histopathologic inflammatory changes. Granulomas are not seen, and if present, may be helpful in definition of other disorders such as Crohn's disease of the colon, an entity often confused with SCAD. Bacteriologic and parasitic studies for an infectious agent are negative. Normal rectal mucosa(i.e., "rectal sparing") is present and can be confirmed with normal rectal biopsies. SCAD often resolves spontaneously without treatment, or completely after a limited course of therapy with only a 5-aminosalicylate. Recurrent episodes may occur, but most often, patients with this disorder have an entirely self-limited clinical course. Occasionally, treatment with other agents, including corticosteroids, or surgical resection has been required.

关键词： segmental colitis associated Diverticulosis syndrome Ulcerative colitis Diverticulitis segmental colitis Diverticulosis Inflammatory bowel disease

Middle segmental pancreatectomy: A safe and organ-preserving option for benign and low-grade malignant lesions

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World Journal of Gastroenterology 2013年第9期19卷 1458-1465页

作者： Zhi-Yong Du Shi Chen Bao-San Han Bai-Yong Shen Ying-Bing Liu ChengHong Peng Department of General Surgery Xinhua Hospital Shanghai Jiaotong University School of Medicine Department of General Surgery Ruijin Hospital Shanghai Jiaotong University School of Medicine Department of Hepatobiliary Surgery Fujian Provincial Hospital

AIM: To study the feasibility and safety of middle segmental pancreatectomy (MSP) compared with pancreaticoduodenectomy (PD) and extended distal pancreatectomy (EDP). METHODS: We studied retrospectively 36 cases that underwent MSP, 44 patients who underwent PD, and 26 who underwent EDP with benign or low-grade malignant lesions in the mid-portion of the pancreas, between April 2003 and December 2009 in Ruijin Hospital. The perioperative outcomes and long-term outcomes of MSP were compared with those of EDP and PD. Periop-erative outcomes included operative time, intraoperative hemorrhage, transfusion, pancreatic fistula, intraabdominal abscess/infection, postoperative bleeding, reoperation, mortality, and postoperative hospital time. Long-term outcomes, including tumor recurrence, newonset diabetes mellitus (DM), and pancreatic exocrine insufficiency, were evaluated. RESULTS: Intraoperative hemorrhage was 316.1 ± 309.6, 852.2 ± 877.8 and 526.9 ± 414.5 mL for the MSP, PD and EDP groups, respectively (P < 0.05). The mean postoperative daily fasting blood glucose level was significantly lower in the MSP group than in the EDP group (6.3 ± 1.5 mmol/L vs 7.3 ± 1.5 mmol/L, P < 0.05). The rate of pancreatic fistula was higher in the MSP group than in the PD group (42% vs 20.5%, P = 0.039), all of the fistulas after MSP corresponded to grade A (9/15) or B (6/15) and were sealed following conservative treatment. There was no significant difference in the mean postoperative hospital stay between the MSP group and the other two groups. After a mean follow-up of 44 mo, no tumor recurrences were found, only one patient (2.8%) in the MSP group vs five (21.7%) in the EDP group developed new-onset insulin-dependent DM postoperatively (P = 0.029). Moreover, significantly fewer patients in the MSP group than in the PD (0% vs 33.3%, P < 0.001) and EDP (0% vs 21.7%, P = 0.007) required enzyme substitution. CONCLUSION: MSP is a safe and organ-preserving option for benign or low-grade mal

关键词： Middle segmental pancreatectomy Pancreaticoduodenectomy Extended distal pancreatectomy Pancreatic fistula Pancreatic endocrine function Pancreatic exocrine function

Diagnosis and management of fibromuscular dysplasia and segmental arterial mediolysis in gastroenterology field: A mini-review

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World Journal of Gastroenterology 2018年第32期24卷 3637-3649页

作者： Masayoshi Ko Kenya Kamimura Kohei Ogawa Kentaro Tominaga Akira Sakamaki Hiroteru Kamimura Satoshi Abe Kenichi Mizuno Shuji Terai Division of Gastroenterology and Hepatology Graduate School of Medical and Dental Sciences Niigata University

The vascular diseases including aneurysm, occlusion, and thromboses in the mesenteric lesions could cause severe symptoms and appropriate diagnosis and treatment are essential for managing patients. With the development and improvement of imaging modalities, diagnostic frequency of these vascular diseases in abdominal lesions is increasing even with the small changes in the vasculatures. Among various vascular diseases, fibromuscular dysplasia(FMD) and segmental arterial mediolysis(SAM) are noninflammatory, nonatherosclerotic arterial diseases which need to be diagnosed urgently because these diseases could affect various organs and be lethal if the appropriate management is not provided. However, because FMD and SAM are rare, the cause, prevalence, clinical characteristics including the symptoms, findings in the imaging studies, pathological findings, management, and prognoses have not been systematically summarized. Therefore, there have been neither standard diagnostic criteria nor therapeutic methodologies established, to date. To systematically summarize the information and to compare these disease entities, we have summarized the characteristics of FMD and SAM in the gastroenterological regions by reviewing the cases reported thus far. The information summarized will be helpful for physicians treating these patients in an emergency care unit and for the differential diagnosis of other diseases showing severe abdominal pain.

关键词： Fibromuscular dysplasia segmental arterial mediolysis Mesenteric lesion diagnosis Humans

SegHMC:一种基于segmental HMM模型的顺式调控模块识别算法

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自动化学报 2016年第11期42卷 1718-1731页

作者：郭海涛霍红卫于强西安电子科技大学计算机学院西安710071

顺式调控模块(Cis-regulatory module,CRM)在真核生物基因的转录调控中起着重要作用,识别顺式调控模块是当前计算生物学的一个重要课题.虽然当前有许多计算方法用于识别顺式调控模块,但识别准确率仍有待进一步提高.将顺式调控模块的多... 详细信息

顺式调控模块(Cis-regulatory module,CRM)在真核生物基因的转录调控中起着重要作用,识别顺式调控模块是当前计算生物学的一个重要课题.虽然当前有许多计算方法用于识别顺式调控模块,但识别准确率仍有待进一步提高.将顺式调控模块的多种特征信息结合在一起,有助于提高识别顺式调控模块的准确率.基于此,本文提出了一种识别顺式调控模块的算法Seg HMC(segmental HMM model for discovery of cis-regulatory module).该算法建立了一种关于顺式调控模块识别问题的segmental HMM模型,进一步扩展了顺式调控模块调控结构(或调控语法)的表示,不仅将顺式调控模块表示为模体(Motif)的组合,还进一步将模体共同出现的频率、模体顺序偏好以及顺式调控模块中相邻模体间的距离分布等特征引入到顺式调控模块的调控语法中.在模拟数据集和真实生物数据集上的实验结果表明,本文方法识别顺式调控模块的准确率显著优于当前的主要方法.

关键词：基因的转录调控模体 segmental HMM 顺式调控模块识别

New Mutation of Coenzyme Q10 Monooxygenase 6 Causing Podocyte Injury in a Focal segmental Glomerulosclerosis Patient

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Chinese Medical Journal 2018年第22期131卷 2666-2675页

作者： Cheng-Cheng Song Quan Hong Xiao-Dong Geng Xu Wang Shu-Qiang Wang Shao-Yuan Cui Man-Di Guo Ou Li Guang-Yan Cai Xiang-Mei Chen Di Wu Department of Nephrology Chinese People's Liberation Army General HospitalChinese People's Liberation Army Institute of NephrologyState Key Laboratory of Kidney Diseases (2011DAV00088)National Clinical Research Center for Kidney DiseasesBeijing Key Laboratory of Kidney DiseasesBeijing 100853China

Background:Focal segmental glomerulosclerosis (FSGS)is a kidney disease that is commonly associated with proteinuria and the progressive loss of renal function,which is characterized by podocyte injury and the depletion and collapse of glomerular capillary *** pathogenesis of FSGS has not been completely elucidated;however,recent advances in molecular genetics have provided increasing evidence that podocyte structural and functional disruption is central to FSGS ***,we identified a patient with FSGS and aimed to characterize the pathogenic gene and verify its mechanism. Methods:Using next-generation sequencing and Sanger sequencing,we screened the causative gene that was linked to FSGS in this *** patient's total blood RNA was extracted to validate the messenger RNA (mRNA)expression of coenzyme Q10 monooxygenase 6(COQ6)and validated it by ***6 knockdown in podocytes was performed in vitro with small interfering RNA, and then,F-actin was determined using immunofluorescence *** apoptosis was evaluated by flow cytometry,the expression of active caspase-3was determined by Western blot,and mitochondrial function was detected by MitoSOX. Results:Using whole-exome sequencing and Sanger sequencing,we screened a new causative gene,COQ6,NM_182480:exonl:c.G41A: *** mRNA expression of COQ6 in the proband showed ***,the expression of COQ6,which was validated by immunohistochemistry,also had the same change in the ***,we focused on the COQ6 gene to clarify the mechanism of podocyte *** cytometry showed significantly increased in apoptotic podocytes,and Western blotting showed increases in active caspase-3in si-COQ6 ***,reactive oxygen species (ROS)levels were increased and F-actin immunofluorescence was irregularly distributed in the si-COQ6 group. Conclusions:This study reported a possible mechanism for FSGS and suggested that a new mutation in COQ6,which could c

关键词： Apoptosis Coenzyme Q10 Monooxygenase 6 Mutation Focal segmental Glomerulosclerosis Podocyte

segmental arterial mediolysis, reparative phase: An analysis and case report showing conversion to fibromuscular dysplasia with renal infarction

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World Journal of Cardiovascular Diseases 2014年第2期4卷 50-60页

作者： Richard E. Slavin Julian del Cerro Gonzalez Jose Manuel Machin Angel Robles Rita Maria Regojo Marie Luisa Diez Department of Internal Medicine La Paz University Hospital Madrid Spain Department of Internal Medicine University Hospital Guadalajara Spain Department of Pathology Legacy Emanuel Hospital Portland Oregon USA Department of Pathology University Hospital Guadalajara Spain Family Practice Physician Guadalajara Health Center Cervantes Branch Guadalajara Spain Interventional Radiologist University Hospital Guadalajara Spain

segmental arterial mediolysis (SAM), an uncommon arteriopathy putatively caused by norepinephrine released by alpha-1 adrenergic agonists or some Beta-2 agonists capable of releasing norepinephrine from the peripheral sympathetic nervous system potentially can present ischemic and organ injury symptoms caused by sequelae created in its reparative phase in lieu of catastrophic hemorrhages announced in its injurious phase. The case documents this presentation—the patient presenting renal infarcts and ischemic lesions causing abdominal angina, hypertension and a nephrectomy event developing 10 years after prolonged ritodrine treatment for premature labor. This agent may have directly caused SAM or sensitized the patient to agonists causing SAM encountered at a latter date. A variety of lesions derived from injurious phase arterial injuries characterize reparative phase SAM. All were encountered in a hilar branch of the resected renal artery. These included side-by-side sequela aneurysms grossly forming a large fusiform aneurysm, granulation tissue filling adventitial medial tear spaces in which a dissecting hematomas developed, medial muscle loss centered to the outer media repaired with fibrous tissue, arterial stenosis created by reparative intimal plaques, and arterial thrombo-embolism. These lesions were mirrored in accompanying radiologic studies. The accompanying renal vein exhibited changes consistent with repair of the spastic venous angiopathy that often accompanies abdominal SAM. This angiopathy, putatively induced by Endothelin-1, suggested that this agent played a role in the genesis of the arterial lesions. Angiographic resolution of non-treated sequelae occurred in 5 months either spontaneously or due to treatment with bosentem. Conclusions: The histologic and angiographic changes demonstrate that the clinical onset of reparative SAM may be significantly delayed to produce ischemic lesions, renal infarction and in this case report, medial fibromuscular dy

关键词： segmental Arterial Mediolysis Fibromuscular Dysplasia Ritodrine Renal Infarcts Dissecting Hematoma Intestinal Angina Endothelin-1 Bosentem

segmental arterial mediolysis: A clinical-pathologic review, its role in fibromuscular dysplasia and description and differential diagnosis of the masquerader-muscular artery cystic necrosis

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World Journal of Cardiovascular Diseases 2013年第1期3卷 64-81页

作者： Richard E. Slavin Cascade Pathology Group Department of Pathology Emanuel Hospital and Health Center Portland USA

segmental arterial mediolysis (SAM) is an uncommon non-inflammatory iatrogenic arteriopathy caused by alpha-1 adrenergic agonists or Beta-2 agonists able to release norepinephrine from the peripheral nervous system. Causative agents include adrenergic agonists used to control blood pressure, B-2 tocolytic agonists, and ractopamine used as a repartitioning agent in animal husbandry. The liberated norepinephrine both injures and stimulates a robust reparative response in the muscular arteries in the abdomen, brain base, and coronary arteries. This response may be augmented by endothelin-1 formed in the arterial adventitia. Three types of arterial lesions develop in the injurious stage: 1) apoptotic induced mediolysis, 2) separation of the outer media from the adventitia and 3) the formation of arterial gaps. The latter enlarge, particularly in elderly patients, to form gap-aneurysms complicated by dissections and dissecting an- eurysms that when ruptured cause the calamitous hemorrhages that clinically announce SAM. The other types of injury remain clinically silent but with repair develop sequelae and can metamorphose into fibromuscular dysplasia. The sequelae are mainly asymptomatic but may cause arterial stenosis and ischemic lesions. The definitive diagnosis of SAM re- quires histological conformation but misinterpreta- tion of smooth muscle vacuolar change has caused di- agnostic errors. Muscular artery cystic necrosis a newly named non-inflammatory muscular artery ar- teriopathy may be confused with SAM both clinically and pathologically. This arteriopathy represents the muscular artery equivalent of cystic media necrosis of the elastic arteries since it exhibits similar morphol- ogic features and can occur concomitantly with this entity. Adrenergic agents to counter hemorrhagic shock in SAM are contraindicated since they may intensify injury and create new lesions. The use of norepinehrine antagonists introduces a new, but as yet untested, treatment option for

关键词： segmental Arterial Mediolysis Norepinephrine Adrenergic Agonists Ractopamine Arterial Apoptosis Aneurysms Dissecting Hematomas Arterial Fibromuscular Dysplasia Muscular Artery Cystic Necrosis

segmental Pigmentation Disorder with Congenital Heterochromia Iridis

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Open Journal of Pediatrics 2015年第3期5卷 213-217页

作者： Carmen Madrigal Díez Sara Rodríguez Prado José Héctor Fernández Llaca Primary Paediatric Health Care Centro de Salud Bezana Servicio Cántabro de Salud Spain Department of Opthalmology Hospital de Sierrallana Torrelavega Cantabria Spain Department of Dermatology Hospital Universitario Marqués de Valdecilla Santander Cantabria Spain

We report the case of a 10-year-old girl with congenital complete heterochromia iridis and segmental pigmentation disorder in its hyperpigmented form. We have found no publication that mentions the combination of thes... 详细信息

关键词： Congenital Heterochromia Iridis segmental Pigmentation Disorder Café-au-Lait Macules