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Emerging nanomedicine-based therapeutics for hematogenous metastatic cascade inhibition:Interfering with the crosstalk between “seed and soil”

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Acta Pharmaceutica Sinica B 2021年第8期11卷 2286-2305页

作者： Junyu Wu Yang Long Man Li Qin He Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of Pharmacy Sichuan UniversityChengdu 610064China

Despite considerable progresses in cancer treatment,tumor metastasis is still a thorny issue,which leads to majority of cancer-related *** hematogenous metastasis,the concept of"seed and soil"suggests that the crosstalk between cancer cells(seeds)and premetastatic niche(soil)facilitates tumor *** efforts have been dedicated to inhibit the tumor metastatic cascade,which is a highly complicated process involving various pathways and biological ***,satisfactory therapeutic outcomes are rarely observed,since it is a great challenge to thwart this multi-phase *** advances in nanotechnology-based drug delivery systems have shown great potential in the field of anti-metastasis,especially compared with conventional treatment methods,which are limited by serious side effects and poor *** this review,we summarized various factors involved in each phase of the metastatic cascade ranging from the metastasis initiation to *** we reviewed current approaches of targeting these factors to stifle the metastatic cascade,including modulating primary tumor microenvironment,targeting circulating tumor cells,regulating premetastatic niche and eliminating established ***,we highlighted the multiphase targeted drug delivery systems,which hold a better chance to inhibit ***,we demonstrated the limitation and future perspectives of nanomedicine-based anti-metastasis strategies.

关键词： Tumor metastasis Drug delivery systems Nanomedicine Metastatic cascade seed and soil Tumor microenvironment Circulating tumor cells Premetastatic niche

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