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Autoimmune hepatitis in a patient with immunoglobulin A nephropathy:A case report

World Journal of Clinical Cases 2020年第17期8卷 3828-3834页

作者： You Hyun Jeon Da Woon Kim So Jeong Lee Young Joo Park Hyo Jin Kim Miyeun Han Il Young Kim Dong Won Lee Sang Heon Song Soo Bong Lee Eun Young Seong Department of Internal Medicine Pusan National University School of MedicineBusan 49241South Korea Department of Pathology Pusan National University HospitalBusan 49241South Korea Division of Gastroenterology Department of Internal MedicineBiomedical Research InstitutePusan National University HospitalBusan 49241South Korea Division of Nephrology Department of Internal MedicineBiomedical Research InstitutePusan National University HospitalBusan 49241South Korea Division of Nephrology Department of Internal MedicinePusan National University Yangsan HospitalYangsan 626-770South Korea

BACKGROUND immunoglobulin A nephropathy(IgAN)is the most commonly encountered glomerular disease in Asian *** has a broad clinical presentation,and it is frequently associated with other *** liver disease is well recognized as the leading cause of secondary ***,cases of IgAN associated with autoimmune hepatitis(AIH)have seldom been *** SUMMARY A 63-year-old Korean woman was admitted to Pusan National University Hospital for an evaluation of abdominal pain and elevated liver *** weeks prior,she had presented to our hospital with proteinuria of approximately 1350 mg/d and hematuria and was diagnosed with *** profiles were highly positive for antinuclear antibodies,and symptoms related to portal hypertension including ascites and peripheral edema were present.A diagnosis of AIH was made according to the simplified scoring system of the International Autoimmune Hepatitis *** immunosuppression with prednisolone and azathioprine,rapid deterioration of liver function led to end-stage liver *** a living-donor liver transplantation,liver function gradually improved,and she had maintained stable liver and kidney function at the six months *** Cases of secondary IgAN with chronic liver disease have been frequently reported in the literature but are rarely associated with *** encountered an IgAN patient with concurrent progressive liver failure due to AIH.

关键词： immunoglobulin A nephropathy secondary immunoglobulin a nephropathy Autoimmune hepatitis Liver transplantation Case report

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