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World Journal of Gastroenterology 2008年第40期14卷 6140-6144页

作者： Toru Ishikawa Department of Gastroenterology and Hepatology Saiseikai Niigata Second Hospital

Chronic hepatitis C is a leading cause of hepatocellular carcinoma (HCC) *** (IFN) ther-apy decreases the incidence of HCC in patients with chronic hepatitis *** of chronic-hepatitis-C-related HCC is one of the most important issues in current *** have previously reported that male gender and high titer of hepatitis C virus (HCV) RNA are predictive factors for the development of HCC in HCV-related *** efforts at eradicat-ing or reducing the viral load may reduce the risk for ***,because HCC often recurs after ablation therapy,we performed a trial of IFN in pa-tients with chronic liver disease caused by HCV to see whether IFN therapy decreases recurrence after abla-tion therapy of HCV-related *** using IFN therapy as a secondary prevention,patients with HCC who had received complete tumor ablation showed better sur-vival,primarily as a result of the preservation of liver function and also probably prevention of *** IFN therapy appears to decrease recur-rence after ablation therapy such as radiofrequency ablation (RFA) therapy of HCV-related *** believe that there is a survival benefit in secondary prevention using IFN ***,a controlled study is es-sential to obtain conclusive evidence of the efficacy of this strategy.

关键词： Hepatocellular carcinoma Radiofrequency ablation Interferon secondary prevention

Influence of education and working background on physicians' knowledge of secondary prevention guidelines for coronary heart disease: results from a survey in China

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第3期13卷 231-238页

作者： Yan-jun GONG Tao HONG Jie JIANG Rong-hui YU Yan ZHANG Zhao-ping LIU Yong HUO Department of Cardiology Peking University First Hospital Beijing 100034 China

Background and objective： In clinical practice, the standard of secondary prevention for coronary heart disease （CHD） is quite disappointing in China. The physicians＇ shortage of knowledge of secondary prevention guidelines is thought to be a key factor contributing to the inadequate and delayed translation of guidelines into clinical practice. The purpose of this study is to investigate the influence of physicians＇ characteristics, including their educa- tion and work experience, on their knowledge of secondary prevention in China. Methods： A representative ques- tionnaire survey was made of physicians from cardiology departments in 35 tertiary hospitals in China. The survey contained 19 questions on knowledge of guideline recommendations for the secondary prevention of CHD. We col- lected basic information about the physicians, including their educational degree, clinical practice duration/work experience and geographic region. Results： In total, 864 physicians participated in the survey. Eight hundred and thirty-seven completed questionnaires were analyzed. For 6 of the 19 questions, physicians with a postgraduate degree were more likely to answer correctly than those without such a degree. For 11 of the 19 questions, physicians with more than three years＇ clinical experience were more likely to answer correctly than those who had less than three years＇ experience. For 5 of the 19 questions, *** eastern areas were more likely to answer correctly than those from mid/western areas. The mean total score of correct answers to the questionnaire was 11.69 points. Edu- cational degree and clinical practice duration affected total scores significantly while practice location did not （β=0.500, P=0.004; ,β=0.979, P=0.000; and 8=0.228, P=0.162, respectively）. Even if a relatively low score of 12 is taken as a threshold level of acceptable knowledge （defined as a pass）, the pass rate of all physicians was only 53.9%. Educational degree and clinical practice durat

关键词： Coronary heart disease secondary prevention Guidelines Survey

Naoxintong Capsule for secondary prevention of Ischemic Stroke:A Multicenter,Randomized,and Placebo-Controlled Trial

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Chinese Journal of Integrative Medicine 2022年第12期28卷 1063-1071页

作者： YU Xiao-fei ZHU Xu-ying YUAN Can-xing WU Dan-hong ZHAO Yu-wu YANG Jia-jun WANG Chang-de WUWei-wen LIU Xue-yuan LIU Zhen-guo NIE Zhi-yu DENG Ben-qiang BAO Huan LI Long-xuan WANG Chun-yan ZHANG Hong-zhi ZHANG Jing-si HUANG Ji-han GONG Fan WANG Ming-zhe GUO Yong-mei SUN Yan CAI Ding-fang Department of Neurology and Institute of NeurologyShuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China Department of Neurology Longhua Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200030China DepartmentofNeurology Shanghai Third People'sHospitalAffiliatedto Shanghai JiaoTongUniversityShanghai 201900China Department of Neurology Shanghai SixthPeople's Hospital Affiliated to Shanghai Jiao TongUniversityShanghai 200233China Department of Neurology Shanghai Sixth People's Hospital East BranchShanghai 201306China Department of Neurology Shanghai TCM-Integrated Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200083China Department of Neurology Zhongshan Hospital Qingpu Branch Affiliated to Fudan UniversityShanghai 201799China Department of Neurology Shanghai Tenth People's Hospital Affiliated to Tongji UniversityShanghai 200072China Department of Neurology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Neurology Shanghai Tongji Hospital Affiliated to Tongji UniversityShanghai 200065China Department of Neurology Changhai HospitalShanghai 200433China Department of Neurology Orient Hospital Affiliated to Tongji UniversityShanghai 200120China Department of Neurology Shanghai Pudong New Area Gongli HospitalShanghai 200135China Department of Neurology Shanghai Yangpu Hospital of Traditional Chinese MedicineShanghai 200090China Center for Drug Clinical Research Shanghai University of Traditional Chinese MedicineShanghai 201203China

Objective:To examine whether the combination of Naoxintong Capsule with standard care could further reduce the recurrence of ischemic stroke without increasing the risk of severe ***:A total of 23 Chinese medical centers participated in this *** patients with a history of ischemic stroke were randomlyassigned ina 1:1ratiousing a blockdesign toreceive eitherNaoxintong Capsule(1.2gorally,twice a day)or placebo in addition to standard *** primary endpoint was recurrence of ischemic stroke within 2 *** outcomes included myocardial infarction,death due to recurrent ischemic stroke,and all-cause *** safety of drugs was *** were analyzed using the intention-to-treat principle.

关键词： ischemic stroke Naoxintong Capsule secondary prevention randomized controlled trial Chinese medicine

Awareness intervention for Beijing neurologists regarding secondary prevention of cerebral infarction/transient ischemia Cross-sectional investigation

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Neural Regeneration Research 2008年第3期3卷 333-336页

作者： Ruihua Ma Chunxue Wang Xianwei Wang Yuhui Zhang Yongjun Wang Yilong Wang Xingquan Zhao Jingjing Li Ying Lu Mingjie Xu Zhuo Zhang Li Wang Weiwei Zhang Lang Lin Jiping Tan Yao Li Ming Wei Hongtao Li Department of Neurology Beijing Tiantan Hospital Capital Medical University Beijing 100050 China Department of Neurology Beijing Chuiyangliu Hospital Beijing 100022 China Department of Neurology Beijing Anzhen Hospital Beijing 100029 China Department of Neurology General Hospital of Beijing Military Area Command of Chinese PLA Beijing 100070 China Department of Neurology General Hospital of Chinese PLA Beijing 100853 China Department of Neurology Beijing 6^th Hospital Beijing 100007 China Department of Neurology Beijing Hepingfi Hospital Beijing 100013 China Department of Neurology Beijing Daxing District Hospital Beijing 102600 China

BACKGROUND： Stroke prevention guidelines should be made available application to aid in uniformity, timing, preciseness, and acceptance of disease. OBJECTIVE： To investigate the awareness of neurologists in some Beijing secondary prevention of cerebral infarction/transient ischemia. DESIGN： Cross-sectional study. to neurologists for clinical hospitals of intervention in SETTING： Beijing Tiantan Hospital, Beijing Anzhen Hospital, General Hospital of Beijing Military Area, Command of Chinese PLA, Beijing Chuiyangliu Hospital, Beijing 6^th Hospital, Beijing Hepingli Hospital, and Beijing Daxing District Hospital. PARTICIPANTS： A total of 28 （associate） chief physicians, 58 attending physicians, and 54 resident physicians who engaged in clinical treatment of cerebrovascular diseases were selected from 8 hospitals in Beijing from March to April 2007. All physicians provided informed consent. METHODS： Self-made closed questionnaires were provided for data collection, consisting of 16 questions that were single choice or multiple choice. Specifically, questions 1-7 focused on awareness of blood pressure regulation in different patients and first choice of decompression drug; questions 8-12 focused on awareness of lipid regulation; and questions 13-16 focused on awareness of anti-blood platelet drugs applied in secondary prevention. The scores ranged from 0-100 points, and each question was worth 6.25 points. The scores positively correlated with the awareness rate. To test leveling real-time, the survey lasted for a maximum of 20 minutes. One questionnaire was independently finished by each subject in the survey. MAIN OUTCOME MEASURES： Awareness intervention among neurologists during secondary prevention of cerebral infarction/transient ischemia and questionnaire scores. RESULTS： 140 subjects were included in the final analysis. ① The awareness rate among neurologists for intervention during secondary prevention of cerebral infarction/transient ischemia ranged from 0.7-57.

关键词： secondary prevention cerebral infarction transient ischemic attack cross-sectional study

Use of Evidence-Based Pharmacotherapy for secondary prevention of Coronary Heart Disease:A Chinese Medicine Hospital Versus A General Hospital

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Chinese Journal of Integrative Medicine 2014年第5期20卷 375-380页

作者：徐慧敏蔡宏文戴海斌颜小锋周权徐耕黄兆铨毛威 Department of Pharmacy the Second Affiliated HospitalSchool of MedicineZhejiang University Department of Cardiovascular Medicine the First Affiliated HospitalZhejiang Chinese Medical University Department of Cardiovascular Medicine the Second Affiliated HospitalSchool of MedicineZhejiang University

Objective： To determine differences in adherence to secondary prevention guidelines （pharmacological interventions） among coronary heart disease （CHD） patients between a Chinese medicine （CM） hospital and a general hospital in a Chinese city. Methods： Medical records of 200 patients consecutively discharged from the CM hospital and the general hospital for CHD were reviewed to determine the proportions of eligible patients who received antiplatelet agents, 13-blockers, angiotensin-converting enzyme （ACE） inhibitors or angiotensin receptor blockers （ARBs） and statins at discharge. The effects of patient characteristics and hospital type on the use of these medicines were estimated using logistic regression models. Results： Patients discharged from the CM hospitals were older; more likely females; had greater history of hyperlipidemia, cerebrovascular diseases and less smoker （P〈0.01 or P〈0.05）. They were less likely to receive coronary angiography and percutaneous coronary intervention, and had a longer length of stay than those discharged from the general hospital （P〈0.01 or P〈0.05）. There were no significant differences in antiplatelet agents （96% vs. 100%, P=0.121） or statins （97.9% vs. 100%, P=0.149） use between the CM hospital and the general hospital. In multivadable analyses that adjusted for patient characteristics and hospital type, there was no significant difference in use of 13 -blockers between the CM hospital and the general hospital. In contrast, patients discharged from the CM hospital were less likely to receive ACE inhibitors/ARBs compared with those discharged from the general hospital （odds ratio： 0.3, 95% confidence interval： 0.105-O.854）. Conclusion： In this study, the CM hospital provides the same quality of care in CHD for prescribing evidence-based medications at discharge compared with another general hospital except for ACE inhibitors/ARBs use.

关键词： coronary disease drugs secondary prevention Chinese medicine

Cardiac rehabilitation and its essential role in the secondary prevention of cardiovascular diseases

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World Journal of Clinical Cases 2021年第8期9卷 1761-1784页

作者： Petr Winnige Robert Vysoky Filip Dosbaba Ladislav Batalik Department of Public Health Faculty of MedicineMasaryk UniversityCzech RepublicBrno 62500JihomoravskyCzech Republic Department of Rehabilitation University Hospital BrnoBrno 62500Czech Republic Department of Health Promotion Faculty of Sports StudiesMasaryk UniversityBrno 62500JihomoravskyCzech Republic

Cardiovascular diseases are the most common causes of mortality *** are frequently the reasons for patient hospitalization,their incapability for work,and *** diseases represent a significant socio-economic burden affecting the medical system as well as patients and their *** has been demonstrated that the etiopathogenesis of cardiovascular diseases is significantly affected by lifestyle,and so modification of the latter is an essential component of both primary and secondary *** rehabilitation(CR)represents an efficient secondary prevention model that is especially based on the positive effect of regular physical *** review presents an overview of basic information on CR with a focus on current trends,such as the issue of the various training modalities,utilization,and barriers to it or the use of telemedicine *** attention should be devoted to these domains,as CR continues evolving as an effective and readily available intervention in the future.

关键词： Cardiac rehabilitation secondary prevention Cardiovascular diseases Utilization Barriers Telerehabilitation

Risk factors in cardiovascular patients:Challenges and opportunities to improve secondary prevention

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World Journal of Cardiology 2023年第7期15卷 342-353页

作者： Rahima Gabulova Anna Marzà-Florensa Uzeyir Rahimov Mahluga Isayeva Shahana Alasgarli Afag Musayeva Sona Gahramanova Firdovsi Ibrahimov Farid Aliyev Galib Imanov Rahmana Rasulova Ilonca Vaartjes Kerstin Klipstein-Grobusch Ian Graham Diederick E Grobbee Teaching-Therapeutical Hospital Azerbaijan Medical UniversityBaku AZ1022Azerbaijan Julius Center for Health Sciences and Primary Care University Medical Center UtrechtUtrecht 3508 GANetherlands Department of Cardiology Baku Medical PlazaBaku AZ1014Azerbaijan Department of CHD and Arrhythmias Scientific-Research Institute of CardiologyBaku AZ1072Azerbaijan Department of Cardiology Central Clinic HospitalBaku AZ1006Azerbaijan Heart Center Baku Health CenterBaku AZ1072Azerbaijan Teaching-Surgical Hospital Azerbaijan Medical UniversityBaku AZ1022Azerbaijan Department of Public Health Azerbaijan Medical UniversityBaku AZ1022Azerbaijan Department of Cardiology Trinity College DublinDublin Dublin-2Ireland

BACKGROUND Effective management of major cardiovascular risk factors is of great importance to reduce mortality from cardiovascular disease(CVD).The Survey of Risk Factors in Coronary Heart Disease(SURF CHD)II study is a clinical audit of the recording and management of CHD risk *** was developed in collaboration with the European Association of Preventive Cardiology and the European Society of Cardiology(ESC).Previous studies have shown that control of major cardiovascular risk factors in patients with established atherosclerotic CVD is generally *** is a country in the South Caucasus,a region at a very high risk for *** To assess adherence to ESC recommendations for secondary prevention of CVD based on the measurement of both modifiable major risk factors and their therapeutic management in patients with confirmed CHD at different hospitals in Baku(Azerbaijan).METHODS Six tertiary health care centers participated in the SURF CHD II study between 2019 and *** on demographics,risk factors,physical and laboratory data,and medications was collected using a standard questionnaire in consecutive patients aged≥18 years with established CHD during outpatient *** from 687 patients(mean age 59.6±9.58 years;24.9%female)were included in the *** Only 15.1%of participants were involved in cardiac rehabilitation *** rate of uncontrolled risk factors was high:Systolic blood pressure(BP)(SBP)(54.6%),low-density lipoprotein cholesterol(LDL-C)(86.8%),diabetes mellitus(DM)(60.6%),as well as overweight(66.6%)and obesity(25%).In addition,significant differences in the prevalence and control of some risk factors[smoking,body mass index(BMI),waist circumference,blood glucose(BG),and SBP]between female and male participants were *** cardiovascular health index score(CHIS)was calculated from the six risk factors:Non-or ex-smoker,BMI<25 kg/m2,moderate/vigorous physical activity,controlled BP(<140/90 mmHg;140/80 mmHg

关键词： Coronary heart disease Cardiovascular risk factors secondary prevention Clinical practice guidelines Clinical audit Survey of risk factors

Primary and secondary prevention of colorectal cancer: An evidence- based review

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Family Medicine and Community Health 2017年第1期5卷 78-84页

作者： Sandra J.Gonzalez Maria C.Mejia de Grubb Robert S.Levine Department of Family and Community Medicine Baylor College of MedicineHoustonTXUSA

Colorectal cancer (CRC) is a common cancer that affects one in three men and one in four women worldwide. Late-stage detection is associated with significantly lower 5-year survival rates. Although it is well established that CRC mortality rates have decreased in the past several decades, adoption of routine screening continues to lag behind screening for other common cancers such as cervical and breast cancer. The decrease in overall rates has been attributed, in part, to improved primary and secondary prevention efforts, including smoking prevention and cessation programs, nutritional counseling, and the use of evidence-based screening protocols, as well as access to better treatment. Despite the increased screening rates, it is estimated that at least one-third of eligible people do not receive appropriate screening. The objective of this review is to describe the current epidemiology of CRC and to demonstrate effective primary and secondary prevention strategies for the primary care provider.

关键词： Colorectal cancer adenocarcinoma modifiable risk factors primary prevention secondary prevention primary care

The utilization status of aspirin for the secondary prevention of ischemic stroke

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Chinese Medical Journal 2009年第2期122卷 165-168页

作者： KE Xian-jun YU Yong-fei GUO Zhen-li XU Kang HAI Hong ZHANG Ai-he JIANG Hong PENG Hong Department of Neurology People's Hospital of East and West Lake District Wuhan Hubei 430040 China

Background The present study was aimed to investigate the usage of aspirin for the secondary prevention of ischemic stroke, evaluate the correlated factors, and analyze the reasons for not taking and irregularly taking aspirin. Methods The patients in this group were all stroke survivors who have formerly been diagnosed with a cerebral infarction or transient ischemic attack （TIA） in our hospital. We investigated their use of aspirin over a three-year period following their hospitalization. According to the patients＇ aspirin usage, they were divided into treatment and non-treatment groups. In addition, the reasons for not taking or irregularly taking aspirin were analyzed in the two groups. Results A total of 1240 patients were studied, including 367 （29.60%） in the treatment group and 873 （70.40%） cases in the non-treatment group. In addition, 201 （16.20%） cases in the treatment group had been regularly taking aspirin （50-325 mg of aspirin daily） for 1 to 3 years or longer. The results demonstrated that the main reasons for not taking aspirin in this study were related to patients＇ concerns regarding the side effects of taking aspirin （46.45%）, as well as the doctors＇ inadequacy in informing their patients to take aspirin （38.71%）. The major reasons for patients to irregularly take aspirin were that the doctors did not notify the length of aspirin usage to their patients （41.57%）, and that doctors did not prescribe aspirin upon the patients＇ follow-up visit （26.51%）. Conclusion The most effective way to increase patient＇s compliance for aspirin consumption is to promote the guidelines for stroke treatment and to relay these advances in stroke therapy to the patient. Chin Med J 2009; 122（2）： 165-168

关键词： ischemic stroke aspirin secondary prevention

Physical activity in primary and secondary prevention of cardiovascular disease:Overview updated

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World Journal of Cardiology 2016年第10期8卷 575-583页

作者： Alberto J Alves Joao L Viana Suiane L Cavalcante Nórton L Oliveira JoséA Duarte Jorge Mota JoséOliveira Fernando Ribeiro Research Centre in Sports Sciences Health and Human DevelopmentCIDESDUniversity Institute of Maia Research Center in Physical Activity Health and LeisureCIAFELFaculty of SportUniversity of Porto School of Health Sciences and Institute of Biomedicine iB iM EDUniversity of Aveiro

Although the observed progress in the cardiovascular disease treatment, the incidence of new and recurrent coronary artery disease remains elevated and constitutes the leading cause of death in the developed countries. Three-quarters of deaths due to cardiovascular diseases could be prevented with adequate changes in lifestyle, including increased daily physical activity. New evidence confirms that there is an inverse dose-response relationship between physical activity and cardiovascular disease and mortality risk. However, participation in moderate to vigorous physical activity may not fully attenuate the independent effect of sedentary activities on increased risk for cardiovascular diseases. Physical activity also plays an important role in secondary prevention of cardiovascular diseases by reducing the impact of the disease, slowing its progress and preventing recurrence. Nonetheless, most of eligible cardiovascular patients still do not benefit from secondary prevention/cardiac rehabilitation programs. The present review draws attention to the importance of physical activity in the primary and secondary prevention of cardiovascular diseases. It also addresses the mechanisms by which physical activity and regular exercise can improve cardiovascular health and reduce the burden of the disease.

关键词： Physical activity Primary prevention secondary prevention Cardiovascular disease Health care evaluation mechanisms