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Simultaneous determination of metronidazole and tinidazole in plasma by using HPLC-DAD coupled with second-order calibration

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Chinese Chemical Letters 2010年第10期21卷 1223-1226页

作者： Li Qun Ouyang Hai Long Wu Ya Juan Liu Jian Yue Wang Yong Jie Yu Hong Yan Zou Ru Qin Yu State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical Engineering Hunan University Changsha 410082 China Zhoushan Municipal Center for Disease Control & Prevention Zhoushan 310062 China

A method using HPLC-DAD coupled with second-order calibration was developed to simultaneously determine metronidazole and tinidazole in plasma samples in this paper. The second-order calibration method based on APTLD （alternating penalty trilinear decomposition） algorithm was proposed to analyze the three-way HPLC-DAD data from both standard and prediction samples, which makes it possible that calibration can be performed even in the presence of unknown interferences with a simple and green chromatographic condition and short analysis time. The results showed that good recoveries were obtained although the chromatographic and spectral profiles of the analytes of interest as well as background were partially overlapped with each other in plasma samples.

关键词： HPLC-DAD second-order calibration Alternating penalty trilinear decomposition (APTLD) Metronidazole Tinidazole Plasma

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Rapid Determination of Costunolide and Dehydrocostuslactone in Human Plasma Sample and Chinese Patent Medicine Xiang Sha Yang Wei Capsule Using HPLC-DAD Coupled with second-order calibration

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Chinese Journal of Chemistry 2012年第5期30卷 1137-1143页

作者：刘亚娟吴海龙朱绍华康超许慧苏志义谷惠文俞汝勤 State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangshaHunan 410082China Hunan Entry-Exit Inspection and Quarantine Bureau ChangshaHunan 410082China

A novel methodology that combines high performance liquid chromatography with photodiode-array detector （HPLC-DAD） coupled with second-order calibration method based on alternating trilinear decomposition （ATLD） algorithm was used in determination of the effective constituents such as costunolide and dehydrocostuslactone, in plasma sample and Chinese patent medicine Xiang Sha Yang Wei （XSYW） capsule. Complicated systems such as plasma and Chinese patent medicine which have intricate components are tedious to isolate and purify. The problem that chromatographic peaks are heavily overlapped among the analytes and interferents from the background matrices can be resolved, and the satisfactory quantification results have been gained with the help of the ATLD algorithm which utilized ＂mathematical separation＂ instead of partial ＂physical or chemical separation＂. Meanwhile, HPLC-MS/MS method was used to validate the accuracy of the proposed determination method.

关键词： costunolide dehydrocostuslactone HPLC-DAD second-order calibration alternating trilinear decomposition

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Pharmacokinetic Analysis of Four Bioactive Iridoid and Secoiridoid Glycoside Components of Radix Gentianae Macrophyllae and Their Synergistic Excretion by HPLC-DAD Combined with second-order calibration

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Natural Products and Bioprospecting 2017年第6期7卷 445-459页

作者： Tian-Ming Yang Yang-Xi Liu Hai-Yan Fu Wei Lan Han-Bo Su He-Bin Tang Qiao-Bo Yin He-Dong Li Li-Ping Wang Hai-Long Wu The Modernization Engineering Technology Research Center of Ethnic Minority Medicine of Hubei Province School of Pharmaceutical SciencesSouth-Central University for NationalitiesWuhan 430074China State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China

An HPLC-DAD method combined with second-order calibration based on the alternating trilinear decomposition(ATLD)algorithm with the aid of region selection was developed to simultaneously and quantitatively characterize the synergistic relationships and cumulative excretion of the four bioactive ingredients of Radix Gentianae Macrophyllae in *** the analytes spectra substantially overlapped with that of the biological matrix,the overlapping profiles between analytes and co-eluting interferences can be successfully separated and accurately quantified by the ATLD method on the basis of the strength of region *** proposed approach not only determined the content change but also revealed the synergistic relationships and the cumulative excretion in vivo of the four ingredients in urine and feces samples collected at different excretion time *** addition,several statistical parameters were employed to evaluate the accuracy and precision of the *** results were confirmed by HPLC-mass *** results indicated that the proposed approach can be utilized to investigate the pharmacokinetics of Radix Gentianae Macrophyllae excretion in vivo.

关键词： Radix Gentianae Macrophyllae HPLC-DAD second-order calibration Pharmacokinetic analysis

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