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second-trimester maternal β-human chorionic gonadotropin level associated with subsequent development of pregnancy-induced hypertension

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Journal of Medical Colleges of PLA(China) 2010年第5期25卷 293-297页

作者： Tang Longying Chen Qizhen Zuo Wanxin Sun Tingwei Wang Yianshu Jin Hua Department of Obstetrics and Gynecology Shanghai Changning Central Hospital Shanghai 200334 China Department of Obstetrics and Gynecology Shanghai First People's Hospital Baoshan Branch Shanghai 200940 China

Objective:To determine whether maternal β-human chorionic gonadotropin(β-hCG) level in second-trimester may be associated with subsequent development of pregnancy-induced hypertension(PIH).Methods:Seven hundred and sixty-two women in mid-trimester were to have maternal urine β-hCG standardized concentrations and maternal serum β-hCG *** case histories were recorded and reviewed from mid-trimester to *** relation was observed between maternal urine,serum markers and subsequent development of ***:Among 762 women,504 cases were normal pregnancies,42 cases had PIH,94 cases had premature rupture of membrane (PROM),69 cases had preterm delivery (PD),53 other cases were excluded by various *** levels of maternal urine,serum β-hCG in PIH were (61.75±9.78) IU/L and (304.56±54.17) ng/mg respectively,which were higher significantly than normal pregnancy group ([20.65±7.61] IU/L and [146.34±47.81] ng/mg,Ptrimester urine,serum β-hCG levels is not only an early signal for dysfunction of placenta but also a dangerous signal for development of ***-trimester maternal urine β-hCG measurement proves to be superior to serum marker in clinical prediction.

关键词： second-trimester β-human chorionic gonadotropin Pregnancy-induced hypertension Placenta

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Comparison of two misoprostol regimens for cervical priming before surgical pregnancy termination at 13 to 16 weeks gestations

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Open Journal of Obstetrics and Gynecology 2011年第4期1卷 187-190页

作者： Dennis G. Chambers Robin J. Willcourt Anthony R. Laver Jane K. Baird Wye Y. Herbert 不详

Background: The optimal regimen has still to be determined for the use of misoprostol in the surgical termination of pregnancy in the early second trimester. Objective: To compare the outcomes of two different regimens for cervical priming with misoprostol before dilatation and evacuation (D & E) in 13 weeks - 16 weeks gestation pregnancy terminations. Methods: A retrospective analysis was performed of the medical records of two cohorts of 334 women each who were treated with either 3 sublingual doses of 2 misoprostol 200 μg tablets 30 minutes apart on admission or the same dosage preceded by 1 oral tablet of misoprostol 200 μg at home 3 hours before admission. Results: The addition of the home tablet of misoprostol increased the rate of one day completion of D & E from 97.3% to 100% (P = 0.004), and the overall mean theatre time for D&E was reduced by 12.3% in parous women (P = 0.001) and 6.4% in nulliparous women (P = 0.003) with the reduction being consistent across all gestations. Conclusions: This retrospective study showed that the addition of 1 oral tablet of misoprostol 200 μg at home 3 hours before admission to a regimen of 3 sublingual doses of 2 misoprostol 200 μg tablets 30 minutes apart on admission significantly increases the probability of all women at 13 weeks - 16 weeks gestation completing a termination of pregnancy in one day with a single D & E procedure and with a reduced theatre time.

关键词： Early second-trimester Surgical Abortion D & E Misoprostol Cervical Priming

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