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Assessing the accuracy of the Modified Chinese Autism Spectrum Rating Scale and Social Responsiveness Scale for screening Autism Spectrum Disorder in Chinese Children

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Neuroscience Bulletin 2017年第2期33卷 168-174页

作者： Bingrui Zhou Hao Zhou Lijie Wu Xiaobing Zou Xuerong Luo Eric Fombonne Yi Wang Weili Yan Xiu Xu Department of Child Healthcare Children’s Hospital of Fudan UniversityShanghai 201102China Department of Neurology Children’s Hospital of Fudan UniversityShanghai 201102China School of Public Health Harbin Medical UniversityHarbin 150081China Child Development Center The Third Affiliated HospitalSun Yat-Sen UniversityGuangzhou 510630China Department of Psychiatry The Second Xiangya Hospital of Central South UniversityChangsha 410011China Oregon Health and Science University PortlandOR 97239USA Department of Clinical Epidemiology Children’s Hospital of Fudan UniversityShanghai 201102China

The reported prevalence of autism spectrum disorder（ASD） has been increasing rapidly in many parts of the world. However, data on its prevalence in China are largely missing. Here, we assessed the suitability of the modi？ed Chinese version of a newly-developed ASD screening tool, the Modi？ed Chinese Autism Spectrum Rating Scales（MC-ASRS） in screening for ASD in Chi nese children aged 6–12 years, through comparison with the Social Responsiveness Scale（SRS） that has been widely used for ASD screening. We recruited the par ents/caregivers of 1588 typically-developing children and190 children with ASD aged 6–12 years to complete the MC-ASRS and SRS, and evaluated the validity of both scales in discriminating children with ASD from those developing typically. The results showed that MC-ASRSperformed as well as SRS in sensitivity, speci？city, and area-under-the-curve（both [0.95） in receiver operating characteristic analysis, with a fair false-negative *** results suggest that MC-ASRS is a promising tool for screening for children with ASD in the general Chinese population.

关键词： Autism spectrum disorder screening accuracy ROC analysis Modi?ed Chinese Autism Spectrum Rating Scale Social Responsiveness Scale

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Performance of the Autism Spectrum Rating Scale and Social Responsiveness Scale in Identifying Autism Spectrum Disorder Among Cases of Intellectual Disability

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Neuroscience Bulletin 2018年第6期34卷 972-980页

作者： Chunpei Li Hao Zhou Tianqi Wang Shasha Long Xiaonan Du Xiu Xu Weili Yan Yi Wang Department of Neurology Children's Hospital of Fudan University Department of Pediatrics Guizhou Provincial People's Hospital Medical College of Guizhou University Department of Child Health Children's Hospital of Fudan University Department of Clinical Epidemiology Children's Hospital of Fudan University State Key Laboratory of Medical Neurobiology Fudan University

The Autism Spectrum Rating Scale(ASRS) and the Social Responsiveness Scale(SRS) have been widely used for screening autism spectrum disorder(ASD) in the general population during epidemiological studies, but studies of individuals with intellectual disability(ID) are quite limited. Therefore, we recruited the parents/caregivers of 204 ASD cases, 71 ID cases aged 6–18 years from special education schools, and 402 typically developing(TD) children in the same age span from a communitybased population to complete the ASRS and SRS. The results showed that the ID group scored significantly lower on total and subscale scores than the ASD group on both scales(P \ 0.05) but higher than TD children(P \ 0.05).Receiver operating characteristic analyses demonstrated a similar fair performance in discriminating ASD from ID with the ASRS(area under the curve(AUC) = 0.709,sensitivity = 77.0%, specificity = 52.1%, positive predictive value(PPV) = 82.2%) and the SRS(AUC = 0.742,sensitivity = 59.8%, specificity = 77.5%, PPV = 88.4%).The results showed that individuals with ID had clear autistic traits and discriminating ASD from ID cases was quite challenging, while assessment tools such as ASRS and SRS, help to some degree.

关键词： Autism spectrum disorder Intellectual disability screening accuracy Autism Spectrum Rating Scale Social Responsiveness Scale

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