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Governance of Violence Risk in Patients with Severe Mental Disorders:From a Case of a schizophrenic’s Filicide

Journal of Forensic Science and Medicine 2023年第2期9卷 190-193页

作者： Da‑Ming Sun Jun‑Nan Huang Criminal Law College East China University of Political Science and LawShanghaiChina

Schizophrenia is a chronic,prolonged illness with a significant tendency to relapse and a high disease *** are often affected by psychotic symptoms and commit violent assaults that manifest as criminal *** the same time,such patients generally have poor medication adherence,which also makes them more likely to commit *** our case,a single mother with a history of psychiatric illness strangled her 4-year-old biological son to death with a rope,put the body in a bathtub and divided it,ate some of the victim’s organs;the results of her forensic mental health identification indicated she was in a period of illness at the time of the offense and did not have the competence for criminal *** adherence is an important factor affecting relapse in patients with *** new medications have been introduced and researchers have been improving medication adherence through many ways such as patient education and family therapy since the 1980s,the level of medication adherence is still poor,with a nonadherence rate of about 50%.This report suggests that in practice,attention should be given to improving patients’medication adherence,guardians of patients and their communities should strengthen their monitoring and care,including knowing the patients’medication adherence and monitoring them to take their medication as prescribed,together with systematic psychotherapy for patients to prevent them from relapsing and committing violent ***,when assessing the patient’s risk of violence,the realistic factors in crime motives and the impact of guardians(family)should be taken into account to evaluate the risk of violence objectively and comprehensively.A final point is that social support for patients with mental disorders and their families should be improved.

关键词： Community care governance of violence risk guardianship schizophrenic

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Computer system for simulation of human perception. Some implications for the pathophysiology of the schizophrenic syndrome

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Journal of Biomedical Science and Engineering 2010年第10期3卷 964-977页

作者： Bernhard J. Mitterauer 不详

After the description of a brain model based on glial-neuronal interactions, a computer system for simulation of human perception, called clocked perception system, is proposed. The computer system includes a receptor field with sensors, each of which receives data with specific characteristics. These data are passed to processors, whereby only those connections between sensors and processors are released that are suited for an evaluation of the data according to a combination of specific data dictated by a phase program circuit. The computer system also includes a selector circuit that discards those dictated program commands that lead to a “senseless” computation result. A motor program circuit for the control of effectors may be connected to the computer system which at least contributes to the movement of the receptor field in order to bring the receptor field closer to suitable data with specific characteristics for better execution of the program. From disorders of the computer system implications are deduced for the pathophysiology of the schizophrenic syndrome. Finally, a novel treatment approach to this syndrome is proposed.

关键词： Glial-Neuronal Interactions Clocked Perception System Technical Implementation schizophrenic Syndrome

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Relationships between clozapine and norclozapine plasma concentrations, clozapine dose, and clinical response in Tunisian patients with schizophrenia-treatment resistance

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Open Journal of Psychiatry 2012年第4期2卷 262-268页

作者： Aida Taieb Fatma B’chir Roland Molinié José-Edmundo Nava-Saucedo Jaafer Nakhli Marc-André Fliniaux Bechir Ben Hadj Ali Saad Saguem Laboratory of Natural Substances National Institute of Research and Physical Chemical Analysis Technopole Sidi Thabet Metabolic Biophysics and Applied Pharmacology Laboratory Department of Biophysics Medicine Faculty of Sousse Sousse Tunisia Psychiatry Department of Central Hospital University (CHU) Sousse Tunisia Unit of Plant Biology and Insect Pests University of Picardy Jules Verne Amiens France

The present study investigated relationships between clozapine dose, clozapine and norclozapine plasma concentrations, and clinical responses to clozapine treatment in Tunisian schizophrenics. Fourteen schizophrenia-treatment resistant patients, recruited for this study, were treated with clozapine for 45 days. Patient health improvement was assessed before and after each cycle of two weeks of clozapine therapy, using the Brief Psychiatric Rating Scale (BPRS). Plasma clozapine and norclozapine concentrations were determined by high-performance liquid chromatography (HPLC). No significant correlations between plasma clozapine and norclozapine concentrations and clinical health improvement among our schizophrenic patients were found. However, a significant correlation was observed between clinical health improvement given by BPRS scores and norclozapine plasma concentration to daily clozapine dose ratio (NCZ/D). Despite the small sample size of our study, our findings suggest that the clozapine therapy response variations observed in our patients may be, in part, explained by the interindividual differences in plasma norclozapine concentration to clozapine dose ratio (NCZ/D). So the NCZ/D parameter could be used as a good indicator for adjusting the clozapine dose-adaptation strategy and consequently for improving the clinical psychopathological state of schizophrenia-treatment resistant patients.

关键词： Clozapine Norclozapine HPLC Tunisian schizophrenic BPRS

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Methods to Be Developed for Some First Applications of Mitochondrial Filamentation

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Open Journal of Biophysics 2013年第1期3卷 51-53页

作者： Mario Gosalvez Laboratorio y Servicio de Bioquímica Experimental Clinica and Hospital Universitario Puerta de Hierro Madrid and Majadahonda Comunidad de Madrid Spain

The new field of mitochondrial filamentation and its first potential applications are just getting underway (1-7), following a series of pilot experiments in our laboratory over the past few decades (8-14). I should like to give a brief overview of the role that some new methods are playing in this emerging area of physiological bioenergetics, supported by a few references to our contributions as I scarcely have the faculties now to understand other specific contributions. This new field is brimming with promises for medicine, science and society, in general. I cannot and must not be concrete or comprehensive, because I honestly feel that it is now that matters are really beginning to take off, assisted by the most appropriate international capabilities.

关键词： Mitochondrial Filamentation schizophrenic Psychoses Obesity

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