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Differentiating snail intermediate hosts of schistosoma *** molecular approaches:fundamental to successful integrated control mechanism in Africa

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Infectious Diseases of Poverty 2018年第1期7卷 301-313页

作者： Eniola Michael Abe Wei Guan Yun-Hai Guo Kokouvi Kassegne Zhi-Qiang Qin Jing Xu Jun-Hu Chen Uwem Friday Ekpo Shi-Zhu Li Xiao-Nong Zhou National Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionKey Laboratory of Parasite and Vector BiologyMOHNational Center for International Research on Tropical DiseasesMinistry of Science and TechnologyWHO Collaborating Centre for Tropical DiseasesShanghai 200020China Department of Pure&Applied Zoology Federal University of Agriculture AbeokutaAbeokutaNigeria

Background:Snail intermediate hosts play active roles in the transmission of snail-borne trematode infections in Africa.A good knowledge of snail-borne diseases epidemiology particularly snail intermediate host populations would provide the necessary impetus to complementing existing control *** body:This review highlights the importance of molecular approaches in differentiating snail hosts population structure and the need to provide adequate information on snail host populations by updating snail hosts genome database for Africa,in order to equip different stakeholders with adequate information on the ecology of snail intermediate hosts and their roles in the transmission of different ***,we identify the gaps and areas where there is need for urgent intervention to facilitate effective integrated control of schistosomiasis and other snail-borne trematode ***:Prioritizing snail studies,especially snail differentiation using molecular tools will boost disease surveillance and also enhance efficient schistosomaisis control programme in Africa.

关键词： Schistosomiasis snail host schistosoma spp. genome database Africa

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Schistosomiasis with special references to the mechanisms of evasion

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Journal of Coastal Life Medicine 2015年第11期 914-923页

作者： Nawras M.El-Saghier Mowafy Ekhlas Hamed Abdel-Hafeez Department of Medical Parasitology Faculty of MedicineMinia UniversityMinya 61519Egypt Department of Medical Parasitology College of MedicineUmm Al-Qura UniversityMakkahKSA

Schistosomiasis is a disease caused by infection with schistosoma *** affects 200 million people worldwide,especially in the developing *** are five known species of schistosoma which currently infect humans in various geographical *** with schistosoma *** to two forms of the disease:acute and *** infection can affect various organs within the human body including the brain,lungs,gut and the reproductive organs,which leads to neuroschistosomiasis,pulmonary schistosomiasis,hepato-intestinal schistosomiasis and urinary genital schistosomiasis,*** schistosoma *** a common denominator that they have the ability to infect,invade and evade the host’s immune *** *** a very complex organism that requires two hosts,mollusk and mammalian,to survive,propagate and complete its life ***,it has developed specific immune evasion mechanisms for each of *** schistosoma *** infected and established itself within its mammalian host as an adult worm,it evades the immune mechanism of that ***,the antigens released by the eggs can elicit an immune response with formation of granuloma around *** formation is the main characteristic lesion in schistosomiasis,which in the liver can cause hepatomegaly in hepato-intestinal *** paper will summarize various immune responses against the parasite as well as varieties of strategies which developed by the schistosoma *** persist within human hosts.

关键词： Schistosomiasis schistosoma spp. Immune responses Evasion mechanism

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Differentiating snail intermediate hosts ofspp. using molecular approaches: fundamental to successful integrated control mechanism in Africa

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贫困所致传染病(英文) 2018年第2期 6-7-8-9-10-11-12-13-14-15-16-17-18页

Background: Snail intermediate hosts play active roles in the transmission of snail-borne trematode infections in Africa. A good knowledge of snail-borne diseases epidemiology particularly snail intermediate host populations would provide the necessary impetus to complementing existing control *** body: This review highlights the importance of molecular approaches in differentiating snail hosts population structure and the need to provide adequate information on snail host populations by updating snail hosts genome database for Africa, in order to equip different stakeholders with adequate information on the ecology of snail intermediate hosts and their roles in the transmission of different diseases. Also, we identify the gaps and areas where there is need for urgent intervention to facilitate effective integrated control of schistosomiasis and other snail-borne trematode ***: Prioritizing snail studies, especially snail differentiation using molecular tools will boost disease surveillance and also enhance efficient schistosomaisis control programme in Africa.

关键词： Schistosomiasis Snail host schistosoma spp. Genome database Africa

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