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Analysis of the anti-T2DM components in dichloromethane fraction of schisandra sphenanthera and its mechanism

Traditional Medicine Research 2025年第1期10卷 27-43页

作者： Shi-Bo Feng Hai-Hui Jiang Hui-Li Kang Yi Jiang Hua-Wei Zhang Xiao-Mei Song Yu-Ze Li Wen-Li Huang Dong-Dong Zhang Chong Deng School of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China School of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine Shaanxi University of Chinese MedicineXianyang 712046China Key Laboratory for Research and Development of“Qin Medicine”of Shaanxi Administration of Traditional Chinese Medicine Xianyang 712046China Shaanxi Key Laboratory of Research and Application of“Taibai Qi Yao” Xianyang 712046China

Background:The type 2 diabetes mellitus(T2DM)pharmacodynamic study of various parts of schisandra sphenanthera was conducted in the previous stage,and it was found that dichloromethane extracted part(SDP)had a significant hypoglycemic ***,the components of SDP were analyzed,and the specific mechanism of its anti-T2DM was ***:We used a high-fat,high-sugar diet in combination with streptozotocin to induce a T2DM rat model,and the model rats were divided into two groups according to body weight and blood ***,oral glucose tolerance test,fasting blood glucose,low density lipoprotein cholesterol,superoxide dismutase,insulin,glycated hemoglobin,total cholesterol,nonesterified free fatty acids,alanine aminotransferase,high-density lipoprotein cholesterol,aspartate aminotransferase,malondialdehyde,and glutathione peroxidase were measured,organ indices were calculated,and pathological sections of pancreas and liver were *** 16S rRNA V3–V4 region of intestinal flora was sequenced to explore the effect of SDP on biochemical indicators and intestinal *** on the above indicators,the anti-T2DM mechanism of SDP in schisandra sphenanthera was ***:After six weeks of administration,the biochemical indices of diabetic rats were diminished compared to the control *** SDP could significantly increase the gut microbialα-diversity index,resulting in significant changes in the flora of T2DM rats,with increased richness and diversity,reduced harmful flora,and significantly back-regulated the levels of acetic acid,propionic acid,and butyric ***:SDP can improve the symptoms associated with elevated blood glucose,dyslipidemia,elevated fasting insulin levels,and damaged glucose tolerance in *** against T2DM may be through the control of intestinal flora to normalize and exert anti-diabetic effect;its main active components may be lignans and terpenoids.

关键词： schisandra sphenanthera T2DM intestinal flora HPLC

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schisandra sphenanthera extract(Wuzhi Tablet)protects against chronic-binge and acute alcohol-induced liver injury by regulating the NRF2-ARE pathway in mice

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Acta Pharmaceutica Sinica B 2017年第5期7卷 583-592页

作者： Xuezhen Zeng Xi Li Chenshu Xu Fulin Jiang Yufei Mo Xiaomei Fan Yaoting Li Yiming Jiang Dongshun Li Min Huang Huichang Bi School of Pharmaceutical Sciences Sun Yat-sen University Department of Pharmacy School of Medicine Shenzhen University Shenzhen Bao'an Maternal and Child Health Hospital

Alcohol abuse leads to alcoholic liver disease and no effective therapy is currently *** Tablet(WZ), a preparation of extract from schisandra sphenanthera that is a traditional hepatoprotective herb, exerted a significant protective effect against acetaminophen-induced liver injury in our recent studies, but whether WZ can alleviate alcohol-induced toxicity remains unclear. This study aimed to investigate the contribution of WZ to alcohol-induced liver injury by using chronic-binge and acute models of alcohol feeding. The activities of ALT and AST in serum were assessed as well as the level of GSH and the activity of SOD in the liver. The expression of CYP2E1 and proteins in the NRF2-ARE signaling pathway including NRF2, GCLC, GCLM, HO-1 were measured, and the effect of WZ on NRF2 transcriptional activity was determined. We found that both models resulted in liver steatosis accompanied by increased transaminase activities, but that liver injury was significantly attenuated by WZ. WZ administration also inhibited CYP2E1 expression induced by alcohol, and elevated the level of GSH and the activity of SOD in the liver. Moreover, the NRF2-ARE signaling pathway was activated by WZ andthe target genes were all upregulated. Furthermore, WZ significantly activated NRF2 transcriptional activity. Collectively, our study demonstrates that WZ protected against alcohol-induced liver injury by reducing oxidative stress and improving antioxidant defense, possibly by activating the NRF2-ARE pathway.

关键词： Alcoholic liver injury schisandra sphenanthera Wuzhi Tablet NRF2-ARE Oxidative stress

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Schisanlactone G,a new 3,4-seco-lanostane triterpenoid from schisandra sphenanthera

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Chinese Chemical Letters 2009年第5期20卷 601-603页

作者： Rong Ren Guo Jun Luo Hong Mei Li Zhao Yuan Wu Hai Zhou Li Rong Tao Li The College of Life Science and Technology Kunming University of Science and Technology Kunming 650224 PR China

A new 3,4-seco-lanostane triterpenoid, schisanlactone G （1）, was isolated from the fruits of schisandra sphenanthera. Its structure was established on the basis of extensive spectroscopic analysis.

关键词： schisandra sphenanthera Triterpenoid Schisanlactone G

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Chemical constituents from schisandra sphenanthera

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Chinese Chemical Letters 2008年第6期19卷 696-698页

作者： Rong Tao Li Zhi Ying Weng Jian Xin Pu Han Dong Sun State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences Kunming 650204 China The College of Life Sciences and Technology Kunming University of Science and Technology 253 Xuehu Road Kunming 650093 China

The chemical constituents of the stems of schisandra sphenanthera are described for the first time. This investigation has resulted in the isolation of a new phenolic glycoside （1）, along with seven known compounds.... 详细信息

关键词： schisandra sphenanthera Phenolic glycoside 4,6-Dihydroxyphenyl-l-butanone-2-β-D-O-glucopyranoside

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华中五味子的化学成分及其抗炎活性研究

华中五味子的化学成分及其抗炎活性研究

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作者：任荣昆明理工大学

学位级别：硕士

The dissertation is composed of four chapters. In the first chapter, the research advance of the chemical constitutes and bioactivities of the family schisandraceae were summarized. In the second chapter, the isolation and identification of the chemical constitutes from the fruits of schisandra sphenanthera Rehd. et Wils were described. Reports in the chapter 3 were about the anti-inflammatory activity of the compounds from S. sphenanthera. The last chapter was a summary report of the research work.(1)S. sphenanthera belongs to the genus schisandra of the family schisandraceae. It is widely distributed in Sichuan, Hubei, Shanxi, Shanxi, Yunnan, Henan province. The fruits of S. sphenanthera are used as an antitussive, tonic and sedative agent under the name of Wuweizi in traditional Chinese medicine together with the fruits of schisandra chinensis Baill. The genus schisandra plants, belonging to the economically and medicinally important family schisandraceae, has proved to be a rich source of dibenzocyclooctadiene lignans, as well as lanostane and cycloartane triterpenes, which have been found to possess many beneficial pharmacological effects. Intensive research on this plant led to the discovery of two drugs:schisantherin A and dimethylbiphenydicarboxylate, for the treatment of hepatitis.(2) In the preceding paper of this plant, we have reported the chemical constituents of the fruits of schisandra sphenanthera, but no new compound was isolated. As a part of our research program to find new compounds with anti-inflammatory activities from S. sphenanthera Rehd. et Wils,19 compounds, including lignans, triterpenoids, steroids, and flavanols, were isolated and identified by the means of chromatographic methods and spectroscopic evidences. Among them, three compounds were showed to be new ones, including a new 3,4-seco-lanostane triterpenoid, schisanlactone G (1) and two new dibenzocyclooctadiene lignans, chloromethyl schisantherin B (2) and methylgomisin O (3

关键词： schisandra sphenanthera lignans triterpenoids anti-inflammatory activity

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