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Validity of subjective assessment as screening tool for dry eye disease and its association with clinical tests

International Journal of Ophthalmology(English edition) 2015年第1期8卷 174-181页

作者： Kavita R Bhatnagar Sonali Pote Sudeep Pujari Dhiraj Deka Department of Ophthalmology Dr.D.Y. Patil Medical CollegeHospital & Research Center

AIM: To determine the role of subjective assessment using Mc Monnies dry eye questionnaire in diagnosing dry eye disease and its association with clinical ***: There were 500 patients screened for dry eye using Mc Monnies dry eye questionnaire between May to October 2013 at the outpatient Department of Ophthalmology of a medical college hospital. All 500 patients were subjected to clinical tests. Dry eye was defined as having one or more symptoms often or all the time. Positive signs were if one or both eyes revealed tear film breakup time(TBUT) of ≤10s, a schirmer test score of ≤10 mm, a Rose Bengal staining score of ≥1, a Lissamine green staining score of ≥1 or existence of meibomian gland disease(≥grade 1). Statistical analysis was performed to describe the distribution of symptoms and signs, to assess the correlations between Mc Monnies score(MS) and variable clinical signs of dry eye, and to explore the association between dry eye symptoms and variable clinical signs. Analysis was performed using software package Epi info. A Probability(P) value using Chi-square test of schirmer test, TBUT, Rose Bengal staining and Lissamine green staining was 25.6%,15.20%, 20.80%, 23.60%, and 22.60% respectively. Among those with severe symptoms(MS>20), 75.86% had a low TBUT(schirmer’s I test(≤10 mm),86.20% had Rose Bengal staining score of ≥1, 79.31%had Lissamine green staining score of ≥1. We found statistically significant associations between positive schirmer test and arthritis(P <0.002), dryness elsewhere(P <0.001), contact lens use(P < 0.002), systemic medication(P <0.0001), sleeping with eyes partly open(P <0.002), history of dry eyes treatment(P <0.0001),environmental factors(P <0.001), swimming(P <0.001).· CONCLUSION: Subjective assessment plays an important role in diagnosing dry eye disease. There is strong c

关键词： Mc Monnies dry eye questionnaire schirmer test tear film breakup time test Rose Bengal staining Lissamine green staining

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Prevalence of Dry Eye and Its Association with Various Risk Factors in Rural Setup of Western Uttar Pradesh in a Tertiary Care Hospital

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Open Journal of Preventive Medicine 2016年第1期6卷 57-63页

作者： Ravi Ranjan Sushil Kumar Shukla Chandra Veer Singh B. N. Mishra Sriti Sinha B. D. Sharma Department of Ophthalmology U. P. Rural Institute of Medical Sciences and Research Saifai India Department of Community Medicine U. P. Rural Institute of Medical Sciences and Research Saifai India Department of Pharmacology U. P. Rural Institute of Medical Sciences and Research Saifai India Department of Community Medicine R. D. Gardi Medical College Ujjain India District Hospital Etawah India

Purpose: To study the prevalence of dry eye in a hospital based population of rural setup and to evaluate its association with various risk factors. Material and Methods: In this cross sectional study, patients above 20 years of age were screened randomly for dry eye. An 8 points questionnaires, slit lamp examination of meibomian glands, tear film breakup time, fluorescein staining of cornea, schirmer test were used to diagnose dry eye. The diagnosis was made when three of the five parameters were positive. The role of various occupations as well as role of different exposure factors like sunlight, excessive wind, smoking, drugs, and air pollution as dry eye risk factors was accessed. Result: Out of 445, 45.39% patients had dry eye. Dry eye prevalence was higher in those above 70 years of age (74%). It was higher in male population (51.82%) compare to female population (37.37%), nearly equal in rural (46.04%) and urban population (44.31%) and highest among factory workers (90%). Correlation of dry eye with drugs (P = 0.0002), sunlight/high temperature (P = 0.0003) and smoking (P = 0.03) were significant. Conclusion: This is a hospital based study which provides prevalence of dry eye in rural region of western Uttar Pradesh. It is more common in old age male population and significantly higher in factory workers. Out of different modifiable risk factors most important are drugs, sunlight/high temperature and smoking.

关键词： Dry Eye Fluorescein Stain schirmer test Tear Film Break up Time

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藻酸盐诱发兔合格伦综合征的实验研究

藻酸盐诱发兔合格伦综合征的实验研究

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第三次全国涎腺疾病学术会议

作者：何巍李龙江郑州大学第一附属医院口腔颌面外科四川大学华西口腔医学院口腔颌面外科

＜正＞研究目的:研究藻酸盐是SS的发病原因之一,采用藻酸盐诱发出类似人类SS的动物模型。研究方法:采用已获藻酸盐免疫的新西兰白兔16只,随机分为A1、B1两组,A2、B2组各为6只正常新西兰白兔作为对照组,间隔1d经腮腺导管灌注藻酸盐,分别... 详细信息

＜正＞研究目的:研究藻酸盐是SS的发病原因之一,采用藻酸盐诱发出类似人类SS的动物模型。研究方法:采用已获藻酸盐免疫的新西兰白兔16只,随机分为A1、B1两组,A2、B2组各为6只正常新西兰白兔作为对照组,间隔1d经腮腺导管灌注藻酸盐,分别于2w（A组）和4w（B组）后检测类似于人类SS在唾液量、施墨实验（schirmer test）、T淋巴细胞亚群、腮腺造影和组织病理等方面的改变。研究结果: A1组和B1组的唾液量明显低于对照组,差异显著,而且,B1组也明显少于A1组,差异显著;schirmer test在A1、B1、A2、B2组中均无差异;腮腺造影的结果:A1组表

关键词： SS 藻酸盐腮腺 schirmer test 腮腺造影 HE染色兔

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