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Spectral Characterization and Antimicrobial Activity of Some Schiff Bases Derived from 4-Methyl-2-aminophenol

Chinese Journal of Chemistry 2012年第4期30卷 970-978页

作者： Gurbuz, Demet Cinarli, Adem Tavman, Aydin Birteksoz, A. Seher Department of Chemistry Faculty of Engineering Istanbul University 34320 Avcilar Istanbul Turkey Department of Pharmaceutical Microbiology Faculty of Pharmacy Istanbul University 34452 Beyazit Istanbul Turkey

A series of N-（5-methyl-2-hydroxyphenyl）-（2/3/4/5-substituted）-benzaldimines （I--XlII） were synthesized us- ing appropriate synthetic route. Their structures were characterized by FT-IR, UV-Visible, ESI-MS, 1H- and 13C-NMR spectroscopic techniques and analytical methods. The crystal structure of N-（5-methyl-2-hydroxyphenyl）- 3,4-dimethoxybenzaldimine （XIII） was determined by X-ray diffraction at room temperature. Relationship between the melting points and the structures of the compounds were examined. Antibacterial activities of the compounds were evaluated against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Klebsiella pneumo- niae, Pseudomonas aeruginosa and Proteus mirabilis. Antifungal activities were reported for Candida albieans. Some of the schiffbases showed considerable antimicrobial activity against S. aureus and C. albicans.

关键词： schiffbases methylhydroxyphenyl spectroscopy X-ray diffraction antimicrobial

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Spectral Characterization and Antimicrobial Activity of Some Schiff Bases Derived from 4-Chloro-2-aminophenol and Various Salicylaldehyde Derivatives

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Chinese Journal of Chemistry 2012年第2期30卷 449-459页

作者： Cinarli, Adem Gurbuz, Demet Tavman, Aydin Birteksoz, A. Seher Istanbul University Faculty of Engineering Department of Chemistry 34320 Avcilar Istanbul Turkey Istanbul University Faculty of Pharmacy Department of Pharmaceutical Microbiology 34452 Beyazit Istanbul Turkey

A series of N-（5-chloro-2-hydroxyphenyl）-（3/4/5-substituted）-salicylaldimines （I--XI） were synthesized using appropriate synthetic route. Their structures were characterized by FT-IR, UV-Visible, ESI-MS, 1H and 13C NMR spectroscopic techniques and analytical methods. The crystal structure of N-（5-chloro-2-hydroxyphenyl）-5-bromo- salicylaldimine （V） was determined by X-ray diffraction at room temperature. Relationship between the melting points and the structures of the compounds was examined. Antimicrobial activity of the compounds was evaluated against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus mirabilis. Antifungal activities were reported for Candida albicans. Schiff bases showed considerable antimicrobial activity against S. aureus, S, epidermidis and C. albicans. N-（5-Chloro-2-hydroxyphenyl）-3-hydroxy-salieylaldimine （II） has the broadest and highest antimicrobial activity according to the others.

关键词： salicylaldimine schiffbases X-ray diffraction spectroscopy antimicrobial

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Synthesis of 4-aminoantipyrine Schiff bases and their antimicrobial activities

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Journal of Chinese Pharmaceutical Sciences 2018年第11期27卷 753-766页

作者： Olatunde S.Oladeji Monisola I.Ikhile Carine M.D.Fotsing Messai Mamo Patrick G.Ndungu Derek T.Ndinteh Department of Applied Chemistry Faculty of Science University of Johannesburg

Various compounds of 4-aminoantipyrine Schiff bases(M1–M12) were synthesized via a condensation reaction of 4-aminoantipyrine with different benzaldehydes through a conventional method of refluxing the mixture for 3–4 h. The synthesized Schiff bases were characterized by using elemental analyses, FT-IR, UV-Vis, Mass, 1 H and 13 C NMR spectroscopy. The antimicrobial activity of the synthesized Schiff bases was investigated against 12 bacterial strains(Mycobacterium smegmatis, Bacillus cereus, Bacillus subtilis, Enterococcus faecalis, Staphylococcus epidermidis, Klebsiella pneumonia, Escherichia coli, Enterobacter cloacae, Klebsiella oxytoca, Proteus vulgaris, Enterobacter aerogenes, and Pseudomonas aeruginosa), and antifungal activities were tested against seven fungal strains(Aspergillus flavus, Aspergillus carbonarious, Aspergillus parasiticus, Aspergillus fumigatus, Aspergillus niger, Fusarium verticillioides and Fusarium proliferatum). The antimicrobial activities of the synthesized compounds were compared with standard streptomycin and nalidixic acid. The results obtained from antibacterial assay indicated that M1–M12 inhibited potential growth of Proteus vulgaris with minimum inhibitory concentrations(MICs) ranging from 15.6–250 μg/mL compared with the standard nalidixic acid with an MIC of 500 μg/mL. Moreover, we could conclude that most of the tested compounds experienced mild to low activities at 15.6 μg/mL. Their activities could be attributed to their low concentration s. The antifungal analysis showed that the tested fungi were not sensitive to the prepared Schiff bases at the prepared concentration of 500 μg/mL. Therefore, we recommended further analysis on both cytotoxicity and minimum bactericidal concentration(MBC) to ascertain their potential effects against human cells.

关键词： 4-Aminoantipyrine Antibacterial schiffbases Antifungal Synthesis Inhibition

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Synthesis and Biological Evaluation of Some Schiff Bases Compounds Derivative of 2,5-di（p-aminophenyl） -3,6-diphenyl Pyrazine

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Journal of Chemistry and Chemical Engineering 2012年第8期6卷 682-685页

作者： Mouayad. N. Mohammed Department of chemistry College of science Qadisyia University Qadisyia 964 Iraq

In this present, a new series of schiffbases from 2,5-di（p-aminophenyl）-3,6-diphenyl pyrazine in the presence of the benzil, 4-bromo benzaldehyde, 4-chlor benzaldehyde, 4-hydroxy benzaldehyde, 4-nitro benzaldehyde and 4-methyl benzaldehyde were studied. The structures of the synthesized compounds were determined on the basis of their Infra-red spectra, H-nuclear magnetic resonase and analysis elemental analysis spectral data. The purity of the synthesized compounds was checked by performing thin layer chromatography. The antibacterial activity was evaluated by paper disc diffusion method.

关键词： P-amino benzaldehyde pyrazine schiffbases synthesis spectroscopic.

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