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In vitro characterization of novel nanostructured collagen-hydroxyapatite composite scaffolds doped with magnesium with improved biodegradation rate for hard tissue regeneration

引用

Bioactive Materials 2021年第10期6卷 3383-3395页

作者： Iulian V.Antoniac Aurora Antoniac Eugeniu Vasile Camelia Tecu Marco Fosca Viktoriya G.Yankova Julietta V.Rau University Politehnica of Bucharest 313 Splaiul Independentei StreetDistrict 6060042BucharestRomania Academy of Romanian Scientists 54 Splaiul Independentei StreetDistrict 5050094BucharestRomania Istituto di Struttura della Materia Consiglio Nazionale delle Ricerche(ISM-CNR)Via del Fosso del Cavaliere10000133RomeItaly Sechenov First Moscow State Medical University Institute of PharmacyDepartment of AnalyticalPhysical and Colloid ChemistryTrubetskaya 8Build.2Moscow119991Russia

New materials are required for bone healing in regenerative medicine able to temporarily substitute damaged bone and to be subsequently resorbed and replaced by endogenous *** inspiration from basic composition of the mammalian bones,composed of collagen,apatite and a number of substitution ions,among them magnesium(Mg2+),in this work,novel composite scaffolds composed of collagen(10%)-hydroxyapatite(HAp)(90%)and collagen(10%)-HAp(80%)-Mg(10%)were *** lyophilization was used for composites *** insight into the nanostructural nature of the developed scaffolds was performed by Scanning Electron Microscopy coupled with Energy Dispersive X-Ray and Transmission Electron Microscopy coupled with Energy Dispersive *** HAp nanocrystallite clusters and Mg nanoparticles were homogeneously distributed within the scaffolds and adherent to the collagen *** samples were tested for degradation in Simulated Body Fluid(SBF)solution by soaking for up to 28 *** release of Mg from collagen(10%)-HAp(80%)-Mg(10%)composite during the period of up to 21 days was attested,this composite being characterized by a decreased degradation rate with respect to the composite without *** developed composite materials are promising for applications as bone substitute materials favouring bone healing and regeneration.

关键词： Composite Collagen Hydroxyapatite Magnesium scaffold Hard tissue regeneration scaffold degradation

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