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Toripalimab in combination with chemotherapy effectively suppresses local recurrence and metastatic sarcomatoid renal cell carcinoma:A case report

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World Journal of Clinical Cases 2024年第28期12卷 6230-6236页

作者： Ming-Zhu Gao Nian-Fei Wang Jin-You Wang Li Ma Yu-Cai Yang Department of Oncology the Second Affiliated Hospital of Anhui Medical UniversityHefei 230601China Department of Urology the Second Affiliated Hospital of Anhui Medical UniversityHefei 230601China Department of Pathology the Second Affiliated Hospital of Anhui Medical UniversityHefei 230601China

BACKGROUND sarcomatoid renal cell carcinoma(SRCC)is a rare variant of renal cell carcinoma associated with an unfavorable *** efficacy of conventional chemo-therapy and targeted therapies are limited,whereas the emergence of immune checkpoint inhibitor has introduced new avenues for managing advanced *** SUMMARY A 77-year-old female patient was referred to our hospital following the incidental detection of a right kidney tumor without specific *** tumor was successfully resected,and subsequent pathological examination confirmed *** experienced both local recurrence and distant metastasis eight months after the initial laparoscopic *** six cycles of toripalimab combined with pirarubicin chemotherapy,the patient achieved a partial ***-quently,the patient attained an almost-complete continuous response to toripa-limab monotherapy maintenance for an additional six *** has not experienced disease progression for 15 months,and her overall survival has reached 24 months thus *** Combination therapy with programmed death 1 antibodies and cytotoxic agents may be a recommended first-line treatment approach for SRCC.

关键词： Renal cell carcinoma sarcomatoid dedifferentiation Immune checkpoint inhibitor Chemotherapy Case report

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