检索结果-南通市图书馆

Changes of macromolecular organizations in nonjunctional sarcolemmas after cross-innervation──a study offast-and slow-twitch muscle fibres in rats

引用

Cell Research 1995年第2期5卷 143-154页

作者： LU JIANLI TIEFENG ZHANG FUJIN QU BEIHUA QIAN SHIKAI HUANG(Shanghai Institute of Physiology, Chinesc Academy of Scicnces, 320 Yue-Yang Road, Shanghai 200031, China) Shanghai Institute of Physiology Chinese Academy of Sciences Shanghai China

The purpose of the present study was to analyse the changes of macromolecular organizations in nonjunctional sarcolemmas of different types of skeletal muscle fibres after cross-innervation. In normal rats the mean density of square arrays (6 nm particles organized in orthogonal arrays) was 9.02/μm2 for the nonjunctional sarcolemmas of fast-twitch extensor digitorum longus (control EDL,CE) nuscle fibres and 0.34/μm2 for the nonjunctional sarcolemmas of slow-twitch soleus (control SOL, CS) muscle fibres. After cross-innervation between the fast-twitch EDL and slow-twitch SOL muscle fibres by slow and fast muscle merves respectively for three months, the mean density was 0.45/μm2 for the nonjunetional sarcolemmas of the operated-EDL (OE) and 8.3/μm2 for the nonjunctional sarcolemmas of the operated SOL (OS). This indicates that the cross-innervation causes a reciprocal transformation of the number and distribution of such macromolecular organizations in the electrically excitable nonjunctional sarcolemmas.

关键词： sarcolemma square array cross-innervation freeze-fracturing rat(Wistar)

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Promising therapeutic approaches of utrophin replacing dystrophin in the treatment of Duchenne muscular dystrophy

引用

Fundamental Research 2022年第6期2卷 885-893页

作者： Ruo Wu Yafeng Song Shiwen Wu Yongchang Chen State Key Laboratory of Primate Biomedical Research&Institute of Primate Translational Medicine Kunming University of Science and TechnologyKunming 650500China Yunnan Key Laboratory of Primate Biomedical Research Kunming 650500China Institute of Sport and Health Science Beijing Sport UniversityNo.48 Xinxi RoadHaidian DistrictBeijing 100084China Department of Neurology Chinese PLA General Hospital28 Fuxing RoadHaidian DistrictBeijing 100853China

Duchenne muscular dystrophy(DMD)is a serious genetic neuromuscular rare disease that is prevalent and caused by the mutation/deletion of the X-linked DMD gene that encodes *** is a dystrophin homologous protein on human chromosome *** and utrophin are highly *** can recruit many dystrophin-glycoprotein complex(DGC)-related proteins and co-localize at the sarcolemma in the early stage of human embryonic ***,utrophin is overexpressed naturally at the mature myofiber sarcolemma in DMD ***,utrophin is considered the most promising homologous protein to replace *** review summarizes various modulating drugs and gene therapy approaches for utrophin *** a universal method to treat DMD disease,utrophin has a promising therapeutic prospect and deserves further investigation.

关键词： Utrophin Dystrophin Duchenne muscular dystrophy sarcolemma Therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：