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Application and mechanisms of sanhua decoction in the treatment of cerebral ischemia-reperfusion injury

World Journal of Clinical Cases 2024年第4期12卷 688-699页

作者： Ya-Kuan Wang Huang Lin Shu-Rui Wang Ru-Tao Bian Yang Tong Wen-Tao Zhang Ying-Lin Cui Department of Encephalopathy The Second Clinical College of Henan University of Chinese MedicineZhengzhou 450000Henan ProvinceChina Department of Encephalopathy Henan Provincial Hospital of Integrated Chinese and Western MedicineZhengzhou 450000Henan ProvinceChina Department of Traditional Chinese Medicine Classics Henan Provincial Hospital of Traditional Chinese Medicine(The Second Affiliated Hospital of Henan University of Chinese Medicine)Zhengzhou 450000Henan ProvinceChina Department of Central Laboratory Zhengzhou Traditional Chinese Medicine HospitalZhengzhou 450000Henan ProvinceChina Department of Encephalopathy Henan Provincial Hospital of Traditional Chinese Medicine(The Second Affiliated Hospital of Henan University of Chinese Medicine)Zhengzhou 450000Henan ProvinceChina Famous Doctor Hall Henan Provincial Hospital of Traditional Chinese Medicine(The Second Affiliated Hospital of Henan University of Chinese Medicine)Zhengzhou 450000Henan ProvinceChina

Cerebral ischemia-reperfusion is a process in which the blood supply to the brain is temporarily interrupted and subsequently ***,it is highly likely to lead to further aggravation of pathological damage to ischemic tissues or the nervous system.,and has accordingly been a focus of extensive clinical *** a traditional Chinese medicinal formulation,sanhua decoction has gradually gained importance in the treatment of cerebrovascular *** main constituents include Citrus aurantium,Magnolia officinalis,rhubarb,and Qiangwu,which are primarily used to regulate *** the treatment of neurological diseases,the therapeutic effects of the sanhua decoction are mediated via different pathways,including antioxidant,anti-inflammatory,and neurotransmitter regu-latory pathways,as well as through the protection of nerve cells and a reduction in cerebral *** the studies conducted to date,many have found that the application of sanhua decoction in the treatment of neurological diseases has clear therapeutic *** addition,as a natural treatment,the sanhua decoction has received widespread attention,given that it is safer and more effective than traditional Western ***,research on the mechanisms of action and efficacy of the sanhua decoctions in the treatment of cerebral ischemia-reperfusion injury is of considerable *** this paper,we describe the pathogenesis of cerebral ischemia-reperfusion injury and review the current status of its treatment to examine the therapeutic mechanisms of action of the sanhua *** hope that the findings of the research presented herein will contribute to a better understanding of the efficacy of this formulation in the treatment of cerebral ischemia-reperfusion,and provide a scientific basis for its application in clinical practice.

关键词： sanhua decoction Cerebral ischemia-reperfusion Mechanism of action Application progress Traditional Chinese medical science Review

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Evaluation of the famous classic formula sanhua decoction based on network pharmacology and multi-component quantitative analysis

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Traditional Medicine Research 2024年第1期9卷 1-13页

作者： Xin Zhang Wan-Cui Wang Jin-Kui Zhang Wei-Mei Zhang Peng-Wang Wang Peng-Cheng Lin Yong-Chang Lu Xia Li Wen-Yuan Gao College of Pharmacy Qinghai Minzu UniversityXining 810000China Qinghai Key Laboratory of Phytochemistry on Qinghai-Tibet Plateau Qinghai Minzu UniversityXining 810000China School of Pharmaceutical Science and Technology Tianjin UniversityTianjin 300000China Qinghai Engineering Technology Research Center of Modern Tibetan Medicine Creation Qinghai Minzu UniversityXining 810000China

Background:sanhua decoction has significant effects in the treatment of *** study of the sanhua decoction material benchmark was carried out to analyze the value transfer relationship between the Chinese herbal pieces and the substance ***:Network pharmacology was employed to investigate the potential active components and molecular mechanisms of sanhua decoction in the treatment of stroke.15 batches of sanhua decoction lyophilized powder were prepared using traditional formulas and subjected to high-performance liquid chromatography analysis to generate fingerprints of the sanhua decoction substance ***,a multi-component quantitative analysis method was established,allowing for the simultaneous determination of ten components,to study the transfer of quantity values between pieces and substance ***:60 active ingredients were screened from sanhua decoction by network pharmacology,of which gallic acid,magnolol honokiol,physcion,and aloe-emodin may have a greater effect than other active components.63 key targets and 134 pathways were predicted as the potential mechanism of sanhua decoction in treating *** fingerprint similarity of the sanhua decoction substance benchmarks was found to be good among the 15 batches,confirming the 19 common *** content of the 10 components was basically *** components’transfer rates were within 30%of their respective ***:This study provided a comprehensive and reliable strategy for the quality evaluation of sanhua decoction substance benchmarks and held significant importance in improving its application value.

关键词： sanhua decoction classic famous formula HPLC fingerprinting value transfer network pharmacology

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