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Challenges and strategies in progress of drug delivery system for traditional Chinese medicine salviae miltiorrhizae radix et rhizoma(Danshen)

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Chinese Herbal Medicines 2021年第1期13卷 78-89页

作者： Ruo-ning Wang Hua-cong Zhao Jian-yu Huang Hong-lan Wang Jun-song Li Yin Lu Liu-qing Di School of Pharmacy Nanjing University of Chinese MedicineNanjing 210046China Jiangsu Engineering Research Center for Efficient Delivery System of TCM Nanjing 210046China Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica Nanjing 210046China

Traditional Chinese medicines(TCMs), with a history of thousands of years, are widely used clinically with effective treatment. However, the drug delivery systems(DDSs) for TCMs remains major challenges due to the characteristics of multi-components including alkaloids, flavones, anthraquinones, glycosides,proteins, volatile oils and other types. Therefore, the novel preparations and technology of modern pharmaceutics is introduced to improve TCM therapeutic effects due to instability and low bioavailability of active ingredients. salviae miltiorrhizae radix et rhizoma, the radix and rhizomes of Salvia miltiorrhiza Bunge(Danshen in Chinese), is a well known Chinese herbal medicine for protecting the cardiovascular system, with active ingredients mainly including lipophilic tanshinones and hydrophilic salvianolic *** this review, this drug is taken as an example to present challenges and strategies in progress of DDSs for TCMs. This review would also summary the characteristics of active ingredients in it including physicochemical properties and pharmacological effects. The purpose of this review is to provide inspirations and ideas for the DDSs designed from TCMs by summarizing the advances on DDSs for both singleand multi-component from Danshen.

关键词： active ingredients challenges and strategies drug delivery systems Salvia miltiorrhiza Bunge salviae miltiorrhizae radix et rhizoma traditional Chinese medicines

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Simultaneous qualitative identification of all medicinal herbs in Zaoren Anshen capsule by thin-layer chromatography

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Journal of Chinese Pharmaceutical Sciences 2022年第7期31卷 499-506页

作者： Manjiang Xie Jie Wang Chenguang Dong Pengfei Tu Qingying Zhang State Key Laboratory of Natural and Biomimetic Drugs and Department of Natural Medicines School of Pharmaceutical SciencesPeking University Health Science CenterBejing 100191China

The holistic characterization and quality control of all the medicinal herbs of proprietary Chinese medicines(PCMs)are of great significance to ensure their safety,efficacy,and ***-layer chromatography(TLC),a simple and classic approach for qualitatively characterizing and examining quality markers of natural products,has been widely used in the characterization and quality control of traditional Chinese *** Anshen(ZRAS)capsule,prepared from three medicinal herbs of fried Ziziphi Spinosae Semen,Salvia Miltiorrhiza radix et rhizoma,and vinegar-processed Schisandrae Chinensis Fructus,is a famous PCM in China for the treatment of insomnia,amnesia,and dizziness in clinical ***,no effective method is available so far for simultaneous identification and examination of all the three medicinal herbs of ZRAS *** the present study,we developed a TLC method via twice-development and visualization by UV light or chromogenic agent,which could be used for simultaneous qualitative identification of all the three medicinal herbs of ZRAS capsule in one ***,the sample preparation method was *** developed TLC method was rapid,simple,low-cost,and effective,and thus it could be used for quality control of ZRAS capsule.

关键词： Zaoren Anshen capsule Ziziphi Spinosae Semen salviae miltiorrhizae radix et rhizoma Schisandrae Chinensis Fructus Thin-layer chromatography Qualitative identification

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