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Protective effects of salvia miltiorrhizae on the hearts of rats with severe acute pancreatits or obstructive jaundice

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第3期10卷 193-202页

作者： Xi-ping ZHANG Guang-hua FENG Jie ZHANG Yang CAI Hua TIAN Xiao-feng ZHANG Yi-feng ZHOU Zhi-wei WANG Ke-yi WANG Department of General SurgeryHangzhou First People 's Hospital Hangzhou 310006 China The First College of Clinical Medicine Zhejiang University of Traditional Chinese Medicine Hangzhou 310053 China Department of General Surgery the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China Department of Digest Hangzhou First People 's Hospital Hangzhou 310006 China Centralab Hangzhou First People's Hospital Hangzhou 310006 China

Objective： To investigate the therapeutic effects and mechanisms of salvia miltiorrhizae （Danshen） in the treatment of severe acute pancreatitis （SAP）- or obstructive jaundice （OJ）-induced heart injury. Methods： A total of 288 rats were used for SAP- （n= 108） and O J-associated （n= 180） experiments. The rats were randomly divided into sham-operated, model control, and salvia miltiorrhizae-treated groups. According to the difference of time points after operation, SAP rats in each group were subdivided into 3, 6 and 12 h subgroups （n=12）, whereas OJ rats were subdivided into 7, 14, 21, and 28 d subgroups （n=lS）. At the corresponding time points after operation, the mortality rates of the rats, the contents of endotoxin and phospholipase A2 （PLA：） in blood, and pathological changes of the hearts were investigated. Results： The numbers of dead SAP and OJ rats in the treated groups declined as compared with those in the model control group, but not significantly （P〉0.05）. The contents ofendotoxin （at 6 and 12 h in SAP rats and on 7, 14, 21, and 28 d in OJ rats, respectively） and PLA2 （at 6 and 12 h in SAP rats and on 28 d in OJ rats, respectively） in the treated group were significantly lower than those in the model control group （P〈0.01 and P〈0.001, respectively）. Besides, myocardial pathological injuries were mitigated in SAP and OJ rats. Conclusion： In this study, we found that salvia rniltiorrhizae improved myocardial pathological changes, reduced the content of PLA2 in blood, and decreased the mortality rates of SAP and OJ rats, exerting protective effects on the hearts of the rats.

关键词： salvia miltiorrhizae Traditional Chinese medicine Severe acute pancreatitis (SAP) Obstructive jaundice (O J) Heart

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