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Allelic functional variation of FimH among salmonella enterica subspecies

Animal Diseases 2023年第4期3卷 265-274页

作者： Xiamei Kang Jiaqi Chen Xiao Zhou Abdelaziz Ed-Dra Min Yue Instituteof Preventive Veterinary Sciences&Department of Veterinary Medicine Zhejiang University College of Animal SciencesHangzhou 310058China Laboratory of Engineering and Applied Technologies Higher School of TechnologySultan Moulay Slimane UniversityPB:591Mghila University Campus23000Beni MellalMorocco Hainan Institute of Zhejiang University SanyaChina Zhejiang Provincial Key Laboratory of Preventive Veterinary Medicine Hangzhou 310058China

salmonella enterica has a wide diversity,with numerous serovars belonging to six different subspecies with dynamic animal-host *** FimH protein is the adhesin mediating binding to various cells,and slight amino acid discrepancy significantly affects the adherence *** date,the general function of FimH variability across dif-ferent subspecies of salmonella enterica has not been *** investigate the biological functions of FimH among the six salmonella enterica subspecies,the present study performed several assays to determine biofilm for-mation,Caenorhabditis elegans killing,and intestinal porcine enterocyte cell IPEC-J2 adhesion by using various FimH allele *** general,allelic mutations in both the lectin and pilin domains of FimH could cause changes in bind-ing affnity,such as the N79S *** also observed that the N79S variation in salmonella Dublin increased the adhesive ability of IPEC-J2 ***,a new amino acid substitution,T260M,within the pilin domain in one subspecies llb strain beneficial to binding to cells was highlighted in this study,even though the biofilm-forming and Caenorhabditis elegans-killing abilities exhibited no significant differences in *** with point muta-tions being a natural tendency due to positive selection in harsh environments,we speculate that allelic variation T26oM probably contributes to pathoadaptive evolution in salmonella enterica subspecies llb.

关键词： salmonella subspecies FimH Amino acid substitution Binding Allelic variation

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