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Postoperative radiotherapy for thymus salivary gland carcinoma:A case report

World Journal of Clinical Cases 2022年第26期10卷 9484-9492页

作者： Rui Deng Nan-Jing Li Liang-Liang Bai Shi-Hong Nie Xiao-Wen Sun Yong-Sheng Wang Clinical Trial Center National Medical Products Administration Key Laboratory for Clinical Research and Evaluation of Innovative DrugsDepartment of Thoracic OncologyWest China HospitalSichuan UniversityCheng Du 610041Sichuan ProvinceChina Department of Radiation Oncology Cancer CenterWest China HospitalSichuan UniversityCheng Du 610041Sichuan ProvinceChina

BACKGROUND salivary gland cancer is a rare disease in which cancer cells form in the tissues of the salivary *** mostly occurs in the glands that have secretion functions,such as the parotid gland,sublingual gland and submandibular *** is very rare when it occurs in other nonsecreting ***,we report one case of salivary gland carcinoma occurring in the thymus and discuss related diagnoses and treatment *** SUMMARY One 33-year-old middle-aged man presented with a thymus mass without any clinical symptoms when he underwent regular physical ***,the patient was admitted to the hospital for further *** tomography(CT)showed that there was a mass of 3 cm×2.8 cm×1.5 cm in the thymus *** patient had no symptom of discomfort or tumor-related medical history *** completing the preoperative examinations,it was confirmed that the patient had indications for *** surgeon performed a transthoracoscope"thymectomy+pleural mucostomy"for *** the operation,the tumor tissue was quickly frozen,and the symptomatic section showed a malignant *** final pathological result suggested thymus salivary gland carcinoma-mucoepidermoid carcinoma(MEC).In the second month after surgery,we performed local area radiotherapy for the patient,with a total radiation dose of 50.4 Gy/*** 12 mo of surgery,the patient underwent positron emission tomography-CT examination,which indicated that there was no sign of tumor recurrence or *** 16 mo of operation,CT scan re-examination showed that there was no sign of tumor recurrence or *** of the time of publication,the patient was followed up for one and a half *** had no sign of tumor recurrence and continued to *** The incidence of MEC in the thymus is low,and its diagnosis needs to be combined with clinical features and imaging *** analysis plays a key role in the diagnosis of the *** w

关键词： Thymic tumor salivary gland carcinoma Mucoepidermoid carcinoma Postoperative Radiotherapy Case report

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The impact of interval between surgery and postoperative radiotherapy in major salivary gland carcinoma

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Journal of the National Cancer Center 2022年第3期2卷 188-194页

作者： Wenbin Yan Xiaomin Ou Chunying Shen Chaosu Hu Department of Radiation Oncology Fudan University Shanghai Cancer CenterShanghaiChina Department of Oncology Shanghai Medical CollegeShanghaiChina

Background:Radiotherapy following primary operation is strongly recommended for salivary gland carcinomas(SGCs)with adverse *** interval between surgery and the initiation of radiotherapy(SRT)varied and a prolonged SRT may cause failure of cancer ***,the association of SRT with survival is unclear in major ***:This retrospective study included a total of 346 patients who underwent radiotherapy after the pri-mary operation from Fudan University Shanghai Cancer Center from 2005 to *** best cutoffvalue of the SRT was determined by the maximum log-rank statistic *** primary endpoint of the study was over-all survival(OS).Correlations between variables and OS were conducted by the univariable analysis using the Log-rank method,and a multivariate Cox proportional hazards regression was performed to identify the indepen-dent prognostic factors associated with *** estimated survival rates were captured using the Kaplan-Meier ***:With a median follow-up time of 70.31 months,the estimated 5-year OS,LRFS,and DMFS were 83.3%,80.1%,and 75.9%,*** cutoffvalue for SRT was 8.5 weeks,while age,T stage,N stage,perineural invasion(PNI),pathological aggression,chemotherapy,and SRT were associated with OS in the univariable *** Cox regression analysis demonstrated that older age(P<0.001),T3-4 tumors(P=0.007),positive N stage(P<0.001),pathological aggression(P=0.014),and longer SRT(P=0.009)were independent prognostic factors for major *** the stratification model,we observed that delay in the SRT was associated with worse OS(P=0.006)in the high-risk group,whereas no significant difference was observed in the low-risk subgroup(P=0.61).Conclusions:The delay in the initiation of postoperative radiotherapy may be a prognostic factor for patients with major *** was suggested that radiotherapy should be delivered within 8.5 weeks following the operation,especially for patients with≥2 risk factors,includin

关键词： salivary gland carcinoma Primary surgery Postoperative radiotherapy Time-interval

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Texture analysis of pretreatment [18F] FDG PET/CT for the prognostic prediction of locally advanced salivary gland carcinoma treated with interstitial brachytherapy

Texture analysis of pretreatment [18F] FDG PET/CT for the pr...

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2019第一届全国口腔颌面-头颈肿瘤学术大会——聚合引领、协同发展

作者：钟奕伟伍文杰北京大学口腔医院

Purpose/Background:The aim of this study was to evaluate the prognostic value of positron emission tomography(PET) parameters and the PET texture features of fluorine 18-fluorodeoxyglucose([18F] FDG) uptake on pretreatment PET/computed tomography(CT) in patients with locally advanced salivary gland carcinoma treated with interstitial brachytherapy.

关键词： Texture analysis PET/CT Prognosis salivary gland carcinoma Brachytherapy

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Expression of cyclin-dependent kinase inhibitor 2A 16,tumour protein 53 and epidermal growth factor receptor in salivary gland carcinomas is not associated with oncogenic virus infection

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International Journal of Oral Science 2015年第1期7卷 18-22页

作者： Ellen Senft Juliana Lemound Angelika Stucki-Koch Nils-Claudius Gellrich Hans Kreipe Kais Hussein Institute of Pathology Hannover Medical School (MHH) Department of Cranio-Maxillo-Facial Surgery Hannover Medical School (MHH)

It is known that human papillomavirus （HPV） infection can cause squamous cell neoplasms at several sites, such as cervix uteri carcinoma and oral squamous carcinoma. There is little information on the expression of HPV and its predictive markers in tumours of the major and minor salivary glands of the head and neck. We therefore assessed oral salivary gland neoplasms to identify associations between HPV and infection-related epidermal growth factor receptor （EGFR）, cyclin-dependent kinase inhibitor 2A （CDKN2A/p16） and tumour protein p53 （TP53）. Formalin-fixed, paraffin-embedded tissue samples from oral salivary gland carcinomas （n=51） and benign tumours （n=26） were analysed by polymerase chain reaction （PCR） analysis for several HPV species, including high-risk types 16 and 18. Evaluation of EGFR, CDKN2A, TP53 and cytomegalovirus （CMV） was performed by immunohistochemistry. Epstein-Barr virus （EBV） was evaluated by EBV-encoded RNA in situ hybridisation. We demonstrated that salivary gland tumours are not associated with HPV infection. The expression of EGFR, CDKN2A and TP53 may be associated with tumour pathology but is not induced by HPV. CMV and EBV were not detectable. In contrast to oral squamous cell carcinomas, HPV, CMV and EBV infections are not associated with malignant or benign neoplastic lesions of the salivary glands.

关键词： cyclin-dependent kinase inhibitor 2A human papillomavirus salivary gland carcinoma

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