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An Updated Overview of the Treatment of Colorectal and Gastric Cancer Using Saffron

Journal of Clinical and Nursing Research 2022年第2期6卷 173-179页

作者： Mahdieh Darroudi Elnaz Nazari Nima Khalili-Tanha Majid Rezayi Majid Khazaei Department of Physiology Faculty of MedicineMashhad University of Medical ScienceMashhadIran Medical Toxicology Research Centre Mashhad University of Medical ScienceMashhadIran Metabolic Syndrome Research Centre Mashhad University of Medical ScienceMashhadIran Department of Medical Biotechnology and Nanotechnology School of ScienceMashhad University of Medical ScienceMashhadIran

Despite the increasing number of drugs and treatments available for cancer patients,the effect of cancer on the quality of life of patients and their life expectancy is ***,many new therapeutic options have shown to have adverse effects without improving *** days,natural plants and chemopreventive drugs are commonly *** is a new form of therapy that targets specific premalignant-malignant ***-derived substances,such as polyphenols,flavonoids,carotenoids,alkaloids,etc.,have a range of biological *** extensive studies on the anti-inflammatory effect of saffron carotenoids,they are also bioactive in some other ways,including the inhibition of tumor growth and the induction of cell *** addition to interfering with a wide array of signaling molecules,this substance has pleiotropic effects:it inhibits pro-inflammatory molecules,transcription factors,enzymes,protein kinases,protein transport proteins,proteins that are crucial for cell survival,growth factors,proteins that regulate the cell cycle,and *** has high oral bioavailability and is,therefore,suitable for treating gastrointestinal *** antioxidant and anti-proliferative property of saffron makes it a promising chemopreventive agent for colorectal *** contrast with in vitro studies devoted to saffron and in vivo studies on animal models,saffron has rarely been assessed in clinical studies dealing with gastrointestinal ***,several clinical trials are in progress in this domain,although saffron has no approved medical indication as of yet.

关键词： safron Colorectal cancer Gastric cancer Chemoprevention Treatment

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