检索结果-南通市图书馆

Food Science and Human Wellness 2023年第6期12卷 2369-2380页

作者： Xiao Hu Yujiao Qian Zhipeng Gao Gaoyang Li Fuhua Fu Jiajing Guo Yang Shan Hunan Agriculture Product Processing Institute International Joint Lab on Fruits&Vegetables ProcessingQuality and SafetyHunan Key Lab of Fruits&Vegetables StorageProcessingQuality and SafetyHunan Academy of Agricultural SciencesChangsha 410125China College of Animal Science and Technology Hunan Agricultural UniversityChangsha 410128China

The microbial potential of Penicillium has received critical *** present research aimed to elucidate the efficacy of crude enzyme secreted from Penicillium oxalicum WX-209 in degrading citrus segments and evaluate the safety of the *** showed that citrus segment membranes gradually dissolved after treatment with the crude enzyme solution,indicating good degradation *** significant differences in body weight,food ingestion rate,hematology,blood biochemistry,and weight changes of different organs were found between the enzyme intake and control *** experiments showed that the crude enzyme had high biological ***,the whole genome of *** WX-209 was sequenced by PacBio and Illumina ***-five scaffolds were assembled to generate 36 Mbp size of genome sequence comprising 11369 predicted genes modeled with a GC content of 48.33%.A total of 592 genes were annotated to encode enzymes related to carbohydrates,and some degradation enzyme genes were identified in strain *** WX-209.

关键词： Penicillium oxalicum WX-209 Crude enzyme Degradation safety evaluation Genome sequencing

safety evaluation of Commercial Vehicle Driving Behavior Using the AHP–CRITIC Algorithm

在线全文

学校读者我要写书评

暂无评论

Journal of Shanghai Jiaotong university(Science) 2023年第1期28卷 126-135页

作者：庞娜罗文广吴若园蓝红莉覃永新苏琦 School of Electrical and Information Engineering Guangxi Key Laboratory of Auto Parts and Vehicle TechnologyGuangxi University of Science and TechnologyLiuzhou 545006GuangxiChina Liuzhou OVM Machinery Co. Ltd.Liuzhou 545005GuangxiChina

To prevent and reduce road traffic accidents and improve driver safety awareness and bad driving be-haviors,we propose a safety evaluation method for commercial vehicle driving *** driving style clas-sification indexes were extracted using driving data from commercial vehicles and four primary and ten secondary safety evaluation *** on the stability of commercial vehicles transporting goods,the acceleration index is divided into three levels according to the statistical third quartile,and the evaluation expression of the safety index evaluation is *** were divided into conservative,moderate,and radical using K-means++.The weights corresponding to each index were calculated using a combination of the analytic hierarchy process(AHP)and criteria importance through intercriteria correlation(CRITIC),and the driving behavior scores of various drivers were calculated according to the safety index score *** established AHP-CRITIC safety evaluation model was verified using the actual driving behavior data of commercial vehicle *** calculation results show that the proposed evaluation model can clearly distinguish between the types of drivers with different driving styles,verifying its rationality and *** evaluation results can provide a reference for transportation management departments and enterprises.

关键词： commercial vehicle driving behavior analytic hierarchy process(AHP) criteria importance through intercriteria correlation(CRITIC) safety evaluation driving style

Pre-clinical study of human umbilical cord mesenchymal stem cell transplantation for the treatment of traumatic brain injury: safety evaluation from immunogenic and oncogenic perspectives

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2022年第2期17卷 354-361页

作者： Gang Wang Hua-Ling Wu Yue-Ping Liu De-Qi Yan Zi-Lin Yuan Li Chen Qian Yang Yu-Song Gao Bo Diao Basic Medical Laboratory General Hospital of the Central Theater CommandWuhanHubei ProvinceChina Hubei Key Laboratory of Central Nervous System Tumor and Intervention WuhanHubei ProvinceChina Department of Clinical Laboratory The Third People’s Hospital of YongzhouYongzhouHunan ProvinceChina Department of Neurosurgery 990th Hospital of Joint Logistic Support Troops of PLAZhumadianHenan ProvinceChina

Stem cell therapy is a promising strategy for the treatment of traumatic brain injury(TBI). However, animal experiments are needed to evaluate safety;in particular, to examine the immunogenicity and tumorigenicity of human umbilical cord mesenchymal stem cells(hu MSCs) before clinical application. In this study, hu MSCs were harvested from human amniotic membrane and umbilical cord vascular tissue. A rat model of TBI was established using the controlled cortical impact method. Starting from the third day after injury, the rats were injected with 10 μL of 5 × 10^(6)/m L hu MSCs by cerebral stereotaxis or with 500 μL of 1 × 10^(6)/m L hu MSCs via the tail vein for 3 successive days. hu MSC transplantation decreased the serum levels of proinflammatory cytokines in rats with TBI and increased the serum levels of anti-inflammatory cytokines, thereby exhibiting good immunoregulatory function. The transplanted hu MSCs were distributed in the liver, lung and brain injury sites. No abnormal proliferation or tumorigenesis was found in these organs up to 12 months after transplantation. The transplanted hu MSCs negligibly proliferated in vivo, and apoptosis was gradually observed at later stages. These findings suggest that hu MSC transplantation for the treatment of traumatic brain injury displays good safety. In addition, hu MSCs exhibit good immunoregulatory function, which can help prevent and reduce secondary brain injury caused by the rapid release of inflammatory factors after TBI. This study was approved by the Ethics Committee of Wuhan General Hospital of PLA(approval No. 20160054) on November 1, 2016.

关键词： cell transplantation immune regulation inflammation mesenchymal stem cells safety evaluation immunogenicity traumatic brain injury tumorigenesis

Novel functional food from an invasive species Polygonum cuspidatum:safety evaluation,chemical composition,and hepatoprotective effects

在线全文

学校读者我要写书评

暂无评论

Food Quality and safety 2022年第4期6卷 678-689页

作者： Yunting Zhang Chengwu Song Hongzhi Du Yulin Chen Xiao Huang Ling Gong Pengtao You Juan Deng Yimei Liu Haidong Feng Zezhi Zhang Kun Yu Yunzhong Chen College of Pharmacy Hubei University of Chinese MedicineWuhanChina Hubei Key Laboratory of Resources and Chemistry of Chinese Medicine Hubei University of Chinese MedicineWuhanChina Shiyan Academy of Agricultural Sciences ShiyanChina Institute of Engineering Technology of Chinese Traditional Medicine and Health Food of Hubei Province WuhanChina

Accidentally,we found that the shoots of Polygonum cuspidatum(SPC)have been consumed for centuries as a traditional vegetable in the Shennongjia region of *** residents believe that SPC has biological effects such as antibacterial,anti-aging,and *** provide scientific support for the use of SPC as a functional food,SPC was evaluated in terms of safety,chemical composition,and antioxidant activity both in vivo and in *** the first,SPC exhibited no adverse cytotoxic effects or acute toxicity in *** the chemical composition of SPC was determined by ultrahigh performance liquid chromatography–electrospray ionization–quadrupole time of flight tandem mass spectrometry(UHPLC-ESI-QTOF-MS/MS).Twenty-two compounds were identified from the SPC extracts,including phenolic,flavonoid,stilbene,and ***,an acute ethanol-induced oxidative stress model in mice showed hepatoprotective *** brief,our study indicated that SPC is a safe,multifunctional food with antioxidant and hepatoprotective ***,the consumption of SPC as a functional food provides a novel strategy for the efficient utilization of the invasive plant.

关键词： Polygonum cuspidatum UHPLC-ESI-QTOF-MS/MS safety evaluation antioxidant activity hepatoprotective effect

safety evaluation Method for Long-Term Operation of Metro Based on Combination Weighting Method

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Shanghai Jiaotong university(Science) 2020年第6期25卷 700-705页

作者： CAO Weiwei LI Mingguang WU Wei XIA Xiaohe SHI Yujin State Key Laboratory of Ocean Engineering Department of Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China Shanghai Institute of Geological Survey Shanghai 200072China

Metros are critical infrastructure in big cities and evaluation of their safe operation is of increasing *** make a reasonable safety evaluation for the metro during operation,this paper establishes a rational safety evaluation model based on long-term monitoring data of Shanghai Metro Line *** evaluation indicators,ie.,absolute settlement,relative curvature,deformation rate and curvature radius,are *** hierar-chy process(AHP)and entropy method are combined to determine the weights of the *** risk level values at different mileage are calculated and five danger levels are defined accordingly to determine the safety state of Shanghai Metro Line 2,ie.,safe,relatively safe,critical,relatively dangerous,and *** evaluation of Shanghai Metro Line 2 shows that:83.81%areas of Shanghai Metro Line 2 are in safe,relatively safe and critical states,while 15.63%and 0.57%areas are in relatively dangerous and dangerous states,respectively;the parts of Shanghai Metro Line 2 where the risk level values exceed the critical value are mainly distributed around the mileage at 6.0-7.5km and 8.5-11.0 km,and the risk level value peaks around the mileage at 7.3km,to which much attention should be attached and relevant protective measures be taken;the sections with the high risk level values coincide with the distinctly deforming arcas of the metro,indicating that this evaluation method is valid.

关键词： long-term deformation safety evaluation combination weighting method Shanghai Metro

safety evaluation of Diacylglycerol Microemulsion in Rats/Mice

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Agricultural Sciences in China 2011年第7期10卷 1117-1124页

作者： HUANG Tao CHEN Ying SHOU Tian-xing YANG Jing LI Duo Department of Food Science and Nutrition Zhejiang University Hangzhou 310029 P.R.China Centre of Nutrition and Food safety of Asia Pacific Clinical Nutrition Society Hangzhou 310029 P.R.China

The objective of the present study was to evaluate potential adverse effects of diacylglycerol microemulsion （DAGM） in rats/mice. Acute safety evaluation was carried out by giving intragastrically with 20 mL 25% DAG kg-1 body weight of DAGM or water with two groups of mice. Chronic safety evaluation with 40 male and 40 female Sprague-Dawley rats was carried out by setting a control group and 3 different dose groups （n=10 male＋10 female） administered with DAGM with 6.7, 10 and 20 mL kg-1 body weight per day. Relevant parameters of liver and kidney function and biochemistry were determined by standard methods at end point. Acute toxicity study revealed the maximum tolerated dose （MTD） of DAGM was 20 mL kg-1 body weight in mice. No death was observed at the dose of 20 mL kg-1 body weight per day. Chronic safety evaluation did not show significant changes on hematological, histopathologic, clinical, and biochemical tests when administered at levels of 6.7, 10 and 20 mL kg-1 body weight per day to rats for 30 d. No significant body weight changes were observed in different dosages in both male and female rats. Our results suggested that acute and chronic adverse effects were not observed in histology and clinical parameters in both mice and rats. The results suggested that DAGM is safe at the experimental levels.

关键词： safety evaluation diacylglycerol microemulsion acute safety chronic safety

New methods of safety evaluation for rock/soil mass surrounding tunnel under earthquake

在线全文

学校读者我要写书评

暂无评论

Journal of Central South University 2014年第7期21卷 2935-2943页

作者：程选生 DOWDING Charles H 田瑞瑞 School of Civil Engineering Lanzhou University of Technology Department of Civil and Environmental Engineering Northwestern University Key Laboratory of Urban Security and Disaster Engineering of Education Ministry Beijing University of Technology

The objective of this work is to obtain the seismic safety coefficient and fracture surface and proceed with the seismic safety evaluation for the rock mass or soil mass surrounding a tunnel,and the limitation of evaluating seismic stability is considered using the pseudo-static strength *** using the finite element software ANSYS and the strength reduction method,new methods of seismic safety evaluation for the rock mass or soil mass surrounding a tunnel are put forward,such as the dynamic finite element static shear strength reduction method and dynamic finite element shear strength reduction *** order to prove the feasibility of the proposed methods,the results of numerical examples are compared with that of the pseudo-static strength reduction *** results show that 1) the two methods are both feasible,and the plastic zone first appears near the bottom corners; 2) the safety factor of new method Ⅱ is smaller than that of new method I but generally,and the difference is very ***,in order to ensure the safety of the structure,two new methods are proposed to evaluate the seismic stability of the rock mass or soil mass surrounding a tunnel.A theoretical basis is provided for the seismic stability of the rock mass or soil mass and the lining surrounding a tunnel and also provided for the engineering application.

关键词： tunnel rock or soil mass surrounding tunnel earthquake stability safety evaluation

safety evaluation of Sustainable Uranium Development in China Combined with an Analytical GAN Framework

在线全文

学校读者我要写书评

暂无评论

Journal of Resources and Ecology 2020年第4期11卷 394-404页

作者： LIU Liangyan CHENG Ming School of Management Wuhan University of Science and TechnologyWuhan 430081China Department of Energy Cycle Technology Wuhan University of Science and TechnologyWuhan 430081China

Uranium is the basic raw material for nuclear energy and is quite highly *** a safe supply of uranium is important for safeguarding sustainable nuclear *** purpose of this study is to evaluate the sustainability of uranium development in China based on dynamic system modeling combined with GAN(Generative Adversarial Network)*** considered eight essential indicators and 42 sub-indicators as part of a detailed quantitative description,and then developed a framework to evaluate and rank China-specific sustainability in light of the quantitative performance of five options for fuel cycle transition *** began by using KMO sample measurements and the Bartlett Test of Sphericity to determine the suitability of factor analysis and the fitness of the corrected model map and observation *** then analyzed the roles of different representatives of the decision makers and their impacts on the overall ranking by applying GAN methods from a weighted *** transition scenarios identified are 1)Pressurized Heavy Water Reactors,2)Mixed Light Water Reactor+Fast Reactor,3)Mixed LWR+FR fuel cycle scheme with heterogeneous irradiation,4)Mixed Pressurized Water Reactor+FR fuel cycle scheme with plutonium recycled directly and repeatedly,and 5)Sodium-cooled fast breeder reactor power *** results showed that scenario 1 is the most unsustainable and highly confrontational scenario with a high demand for uranium resources,the lowest sustainability and a high level of antagonism among *** the other hand,Scenario 5 requires more advanced technology but exhibits less antagonism among the departments,and thus it largely satisfies the basic requirements for uranium sustainability and low levels of *** this paper,a safety assessment index system for the uranium supply is computed using a GAN *** system plays a crucial role in the sustainable supply and development of uranium,and provides flexibility fo

关键词： uranium sustainable development safety evaluation index system

Accelerated testing for automated vehicles safety evaluation in cut-in scenarios based on importance sampling,genetic algorithm and simulation applications

在线全文

学校读者我要写书评

暂无评论

Journal of Intelligent and Connected Vehicles 2018年第1期1卷 28-38页

作者： Yiming Xu Yajie Zou Jian Sun Tongji University ShanghaiChina

Purpose–It would take billions of miles’field road testing to demonstrate that the safety of automated vehicle is statistically significantly higher than the safety of human driving because that the accident of vehicle is rare ***/methodology/approach–This paper proposes an accelerated testing method for automated vehicles safety evaluation based on improved importance sampling(IS)*** the typical cut-in scenario as example,the proposed method extracts the critical variables of the ***,the distributions of critical variables are statistically *** genetic algorithm is used to calculate the optimal IS parameters by solving an optimization *** the error of distribution fitting,the result is modified so that it can accurately reveal the safety benefits of automated vehicles in the real ***–Based on the naturalistic driving data in Shanghai,the proposed method is validated by *** result shows that compared with the existing methods,the proposed method improves the test efficiency by 35 per cent,and the accuracy of accelerated test result is increased by 23 per ***/value–This paper has three ***,the genetic algorithm is used to calculate IS parameters,which improves the efficiency of ***,the result of test is modified by the error correction parameter,which improves the accuracy of test ***,typical high-risk cut-in scenarios in China are analyzed,and the proposed method is validated by simulation.

关键词： Genetic algorithm Simulation Automated vehicles Importance sampling Lane changing safety evaluation High-risk scenarios

The clinical effect and safety evaluation of Shugan Quzhi capsule in the treatment of adult simple obesity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Chinese Pharmaceutical Sciences 2017年第12期26卷 890-894页

作者：林志燕田怀平李方秦丽萍张欣陆晓彤上海交通大学医学院附属新华医院上海200092

Shugan Quzhi capsule is a hospital preparation of Xinhua Hospital affiliated to School of Medicine, Shanghai Jiaotong University. It has been used to treat adult patients with fatty liver caused by obesity, high cholesterol and other factors. In the present study, we investigated the clinical efficacy and safety of Shugan Quzhi capsule in adult simple obesity. The patients were randomly divided into the treatment group and control group. The whole treatment lasted 2 months under the same nutritional condition and diet intervention. Body weight, body mass index, total cholesterol, triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, alanine aminotransferase, aspartate aminotransferase, blood urea nitrogen, creatinine, urine and blood routine examination were recorded before and after treatment. Our data showed that the total effective rate of treatment group was 66.67%, and body weight and body mass index after treatment the body were significantly decreased （P〈0.01）. The levels of total cholesterol, triglyceride, high-density lipoprotein and low-density lipoprotein after treatment were lower than before treatment, but there was no statistical difference （P〉0.05）. The total effective rate of control group was 39.13%, and the body weight and body mass index atter treatment were also significantly lower than before （P〈0.01）. There was no significant difference between the treatment group and control group （P〉0.05）. There were no significant changes in liver function, renal function, urine routine and blood routine examination data after treatment. The results suggested that Shugan Quzhi capsule had certain therapeutic efficacy and safety in adult simple obesity.

关键词： Simple obesity Adult Shugan Quzhi Capsule Clinical efficacy safety evaluation