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World Journal of Gastroenterology 2009年第20期15卷 2456-2462页

作者： Elisabetta Colombo Anna Latiano Orazio Palmieri Fabrizio Bossa Angelo Andriulli Vito Annese Unit of Gastroenterology Department of Medical Sciences IRCCS-CSS Hospital Laboratory of Genetic Research Department of Medical Sciences IRCCS-CSS Hospital Unit of Digestive Endoscopy Department of Medical SciencesIRCCS-CSS Hospital

The association between spondyloarthropathy and in flammatory bowel disease(IBD) is largely established, although prevalence is variable because of different population selection and diagnostic *** studies indicate that as many as 10%15% of cases of IBD are complicated by ankylosing spondylitis(AS) or other forms of spondylarthritis(SpA).Of note, ileal inflammation resembling IBD has been reported in up to two thirds of cases of SpA, and it has been suggested that the presence of ileitis is associated with the chronic ity of articular *** this observation is of interest to unravel the pathophysiology of the disease, systematic screening of patients with SpA by ileocolonos copy is not indicated in the absence of gut symptoms, as only a small proportion of patients with subclinical gut inflammation will develop overt IBD over *** existence of familial clustering of both IBD and AS, the coexistence of both conditions in a patient, the evidence of an increased risk ratio among f irstand seconddegree relatives of affected AS or IBD patients and f inally, the increased crossrisk ratios between AS and IBD, strongly suggest a shared genetic *** far, however, IL23R is the only identified susceptibility gene shared by both IBD and *** functional studies are still needed to better understand its pathogenic role, great ef fort is being spent therapeutically targeting this pathway that may prove effective for both disorders.

关键词： Inflammatory bowel disease Ulcerative colitis Crohn's disease Ankylosing spondlitis sacroiliitis Spondyloarthropathy

Occurrence of human leukocyte antigen B51-related ankylosing spondylitis in a family:Two case reports

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World Journal of Clinical Cases 2022年第3期10卷 992-999页

作者： Mie Jin Lim Eul Noh Ro-Woon Lee Kyong-Hee Jung Won Park Rheumatology/Internal Medicine Inha UniversityIncheon 22332South Korea Radiology Inha UniversityIncheon 22332South Korea

BACKGROUND Ankylosing spondylitis(AS)is strongly associated with the human leukocyte antigen(HLA)B27 *** regions where conventional polymerase chain reaction for HLA typing is available for antigens such as HLA B27 or HLA B51,it is common to perform the HLA B27 test for evaluation of *** HLA B27-associated clustered occurrences of AS have been reported in families,we report the first case series of HLA B51-related occurrences of AS in a *** SUMMARY A father and his daughters were diagnosed with AS and did not have the HLA B27 *** they were positive for HLA B51,they exhibited no signs of Behçet’s disease(BD).Of the five daughters,one had AS,and three,including the daughter with AS,were positive for HLA *** two daughters with the HLA B51 haplotype(excluding the daughter with AS)exhibited bilateral grade 1 sacroiliitis,whereas the daughters without the HLA B51 haplotype did not have ***,this Korean family exhibited a strong association with the HLA B51 haplotype and clinical sacroiliitis,irrespective of the symptoms of *** It is advisable to check for HLA B51 positivity in patients with AS/spondyloarthropathy who test negative for HLA B27.

关键词： Ankylosing spondylitis Spondyloarthropathy Human leukocyte antigen B51 Human leukocyte antigen B27 sacroiliitis Case report

Current issues in pediatric inflammatory bowel diseaseassociated arthropathies

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World Journal of Gastroenterology 2014年第1期20卷 45-52页

作者： Sabrina Cardile Claudio Romano Department of Pediatrics University of Messina98125 MessinaItaly

Joint involvement is the most common extraintestinal manifestation in children with inflammatory bowel disease (IBD) and may involve 16%-33% of patients at diagnosis or during follow-up. It is possible to distinguish asymmetrical, transitory and migrating arthritis (pauciarticular and polyarticular) and spondyloarthropathy (SpA). Clinical manifestations can be variable, and peripheral arthritis often occurs before gastrointestinal symptoms develop. The inflammatory intestinal pattern is variable, ranging from sub-clinical inflammation conditions, classified as indeterminate colitis and nodular lymphoid hyperplasia of the ileum, to Crohn’s disease or ulcerative colitis. Unlike the axial form, there is an association between gut inflammation and evolution of recurrent peripheral articular disease that coincides with a flare-up of intestinal disease. This finding seems to confirm a key role of intestinal inflammation in the pathogenesis of SpA. An association between genetic background and human leukocyte antigen-B27 status is less common in pediatric than n adult populations. Seronegative sacroiliitis and SpA are the most frequent forms of arthropathy in children with IBD. In pediatric patients, a correct therapeutic approach relies on the use of nonsteroidal antiinflammatory drugs, local steroid injections, physiotherapy and anti-tumor necrosis factor therapy (infliximab). Early diagnosis of these manifestations reduces the risk of progression and complications, and as well as increasing the efficacy of the therapy.

关键词： Inflammatory bowel disease Spondyloarthropathy sacroiliitis Infliximab Extraintestinal manifestations

Concurrent ankylosing spondylitis and myelodysplastic syndrome:A case report

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World Journal of Clinical Cases 2022年第6期10卷 1929-1936页

作者： Guan-Hua Xu Jin Lin Wei-Qian Chen Division of Rheumatology The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina

BACKGROUND Ankylosing spondylitis(AS)is an autoimmune disease characterized by sacroiliitis and spondylitis,with a few hematological *** syndromes(MDS)are a heterogeneous group of hematopoietic stem cell disorders with frequent autoimmune *** relationship between AS and MDS remains *** SUMMARY We describe a rare case of concurrent AS and *** 18-year-old man with low back pain and anemia was diagnosed with AS;however,the cause of anemia could not be determined by the first bone marrow *** recovered from anemia and the symptoms of AS resolved after treatment with etanercept,glucocorticoid,and blood transfusion,but he developed pancytopenia with an increased myeloblast count(from 2.5%to 9%).Chromosome analysis revealed del(7q)and trisomy *** anemia with excess of blasts-1(RAEB-1)/MDS was confirmed by repeating the bone marrow *** became blood transfusion-dependent and received decitabine-based chemotherapy but eventually *** We suspect that AS may be an early autoimmune phenomenon related to ***,a condition of coexistence cannot be excluded.

关键词： Ankylosing spondylitis Etanercept Myelodysplastic syndromes sacroiliitis Case report