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World Journal of Gastroenterology 2024年第10期30卷 1280-1286页

作者： Valerie Josephine Dirjayanto Jessica Audrey Daniel Martin Simadibrata Faculty of Medicine Universitas IndonesiaJakarta Pusat 10430DKI JakartaIndonesia Division of Gastroenterology and Hepatology Mayo ClinicRochesterMinnesota 55905United States Nuffield Department of Population Health University of OxfordOxford OX37LFUnited Kingdom

Yu et al’s study in the World Journal of Gastroenterology(2023)introduced a novel regimen of Vonoprazan-amoxicillin dual therapy combined with saccharomyces boulardii(***)for the rescue therapy against Helicobacter pylori(***),a pathogen responsible for peptic ulcers and gastric *** is a potassium-competitive acid blocker renowned for its rapid and long-lasting acid suppression,which is minimally affected by *** to proton pump inhibitors,which bind irreversibly to cysteine residues in the H+/K+-ATPase pump,Vonoprazan competes with the K+ions,prevents the ions from binding to the pump and blocks acid *** with increasing antibiotic resistance,effects on the gut microbiota,patient compliance,and side effects have led to the advent of a dual regimen for *** studies suggested that *** plays a role in stabilizing the gut barrier which improves *** eradication *** an acceptable safety profile,the dual-adjunct regimen was effective regardless of prior treatment failure and antibiotic resistance profile,thereby strengthening the applicability in clinical ***,*** comes in various formulations and dosages,warranting further exploration into the optimal dosage for supplementation in rescue ***,larger,randomized,double-blinded controlled trials are warranted to confirm these promising results.

关键词： Vonoprazan saccharomyces boulardii Helicobacter pylori Rescue therapy Eradication rate

The metabolic profiling of Chinese yam fermented by saccharomyces boulardii and the biological activities of its ethanol extract in vitro

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Food Science and Human Wellness 2024年第5期13卷 2718-2726页

作者： Xue Li Yiwen Shao Limin Hao Qiaozhen Kang Xiaolong Wang Jiaqing Zhu Changcheng Zhao Yanling Shi Jike Lu Juanjuan Yi School of Life Sciences Zhengzhou UniversityZhengzhou 450001China Food Laboratory of Zhongyuan Zhengzhou UniversityLuohe 462300China Systems Engineering Institute Academy of Military Sciences(AMS)Beijing 100010China Henan Yinfeng Biological Engineering Technology Co. Ltd.Zhengzhou 450000China

Chinese yam(Dioscorea opposita Thunb.),as one of the medicinal and edible homologous plants,is rich in various nutrients and functional *** this study,Chinese yam fermented by saccharomyces boulardii was performed to investigate its bioactive components and metabolic *** then,the main bioactive components and biological activities of fermented Chinese yam ethanol extract(FCYE)were *** showed that there were 49 up-regulated metabolites and 52 down-regulated metabolites in fermented Chinese yam compared to unfermented Chinese ***,corresponding metabolic pathways analysis initially revealed that the distribution of bioactive substances was concentrated on alcoholsoluble small molecular ***,the total polyphenol content and the total flavonoid content in FCYE were significantly increased,and the corresponding antioxidant and immunomodulatory activities in vitro were also significantly *** study provided a new reference for the comprehensive utilization of Chinese yam and laid a theoretical foundation for the development and application of natural probiotic-fermented products.

关键词： Chinese yam saccharomyces boulardii Metabolites Antioxidant Immunomodulation

Effectiveness of saccharomyces boulardii in a rat model of colitis

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World Journal of Gastroenterology 2012年第44期18卷 6452-6460页

作者： Mujde Soyturk Saba Mukaddes Saygili Huseyin Baskin Ozgul Sagol Osman Yilmaz Fatih Saygili Hale Akpinar Department of Gastroenterology Dokuz Eylul University School of MedicineInciraltiIzmir 35340Turkey Department of Internal Medicine Mediguven HospitalSalihli 45300ManisaTurkey Department of Clinical Microbiology Dokuz Eylul University School of MedicineInciraltiIzmir 35340Turkey Department of Pathology Dokuz Eylul University School of MedicineInciraltiIzmir 35340Turkey Department of Laboratory Animal Science Dokuz Eylul University School of MedicineInciraltiIzmir 35340Turkey Department of Gastroenterology Pamukkale University School of MedicineDenizli 20070Turkey

AIM:To investigate the effects of saccharomyces boulardii(***) in an experimental rat model of trinitrobenzene sulfonic acid(TNBS)-induced ***:Thirty-two Wistar albino female rats were categorized into five *** the first day of the study,50 mg TNBS was administered via a rectal catheter in order to induce colitis in all rats,except those in the control *** 14 d,the rats were fed a standard diet,without the administration of any additional supplements to either the control or TNBS groups,in addition to 1 mg/kg per day *** to the *** group,1 mg/kg per day methyl prednisolone(MP) to the MP *** animals in the *** + MP group were coadministered these doses of *** and *** the study,weight loss,stool consistency,and the presence of obvious blood in the stool were evaluated,and the disease activity index(DAI) for colitis was *** intestines were examined and colitis was macro-and microscopically *** serum and tissue levels of tumor necrosis factor-α(TNF-α) and nitric oxide(NO) were determined,and fungemia was evaluated in the blood ***:The mean DAI scores for the MP and *** + MP groups was significantly lower than the TNBS group(3.69 ± 0.61 vs 4.46 ± 0.34,P = 0.018 and 3.77 ± 0.73 vs 4.46 ± 0.34,P = 0.025,respectively).While no significant differences between the TNBS and the *** or MP groups could be determined in terms of serum NO levels,the level of serum NO in the *** + MP group was significantly higher than in the TNBS and *** groups(8.12 ± 4.25 μmol/L vs 3.18 ± 1.19 μmol/L,P = 0.013;8.12 ± 4.25 μmol/L vs 3.47 ± 1.66 μmol/L,P = 0.012,respectively).The tissue NO levels in the ***,MP and *** + MP groups were significantly lower than the TNBS group(16.62 ± 2.27 μmol/L vs 29.72 ± 6.10 μmol/L,P = 0.002;14.66 ± 5.18 μmol/Lvs 29.72 ± 6.10 μmol/L,P = 0.003;11.95 ± 2.34 μmol/Lvs 29.72 ± 6.10 μmol/L,P = 0.002,respectively).The tis

关键词： saccharomyces boulardii Rat Trinitroben-zene sulfonic acid Tumor necrOsis factor-m Nitric ox-ide Fungemia

Administration of saccharomyces boulardii mafic-1701 improves feed conversion ratio,promotes antioxidant capacity,alleviates intestinal inflammation and modulates gut microbiota in weaned piglets

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Journal of Animal Science and Biotechnology 2021年第2期12卷 689-699页

作者： Wenxiu Zhang Chengling Bao Jian Wang Jianjun Zang Yunhe Cao State Key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China

Background:Probiotics are used as a means to improve animal health and intestinal *** boulardii is a well-known probiotic;however,few studies have examined the effects of *** on weaned piglet ***,this 28-day study compared the effects of *** mafic-1701 and aureomycin in diets for weaned piglets on growth performance,antioxidant parameters,inflammation and intestinal *** hundred and eight piglets,weaned at 28 d of age(8.5±1.1 kg),were randomly divided into the three dietary treatment groups with six pens and six piglets per pen(half male and half female).The dietary treatment groups were as follows:1)basal diet(CON);2)basal diet supplemented with 75 mg/kg aureomycin(ANT);3)basal diet supplemented with 1×108 CFU/kg *** mafic-1701(SB).Results:Compared to CON group,SB group had higher feed efficiency(P<0.05)in the last 14 d and lower diarrhea rate(P<0.05)over the entire 28 *** superoxide dismutase in serum was markedly increased in SB group(P<0.05).Moreover,compared with CON group,SB group decreased the levels of pro-inflammatory cytokines interleukin-6(P<0.01)and Tumor necrosis factor-α(P<0.05)in *** of *** mafic-1701 increased the abundance of Ruminococcaceae_UCG_009 and Turicibacter(P<0.05),whereas the abundance of unclassified_Clostridiaceae_4 was decreased(P<0.05).Furthermore,*** mafic-1701 administration increased cecal concentration of microbial metabolites,isobutyrate and valerate(P<0.05).Conclusions:The improvement in feed conversion ratio,reduction in diarrhea rate in weaned piglets provided diets supplemented with *** mafic-1701 may be associated with enhanced antioxidant activity,antiinflammatory responses and improved intestinal microbial ecology.

关键词： Inflammation Microbiota saccharomyces boulardii Short chain fatty acid Weaned piglet

Systematic review and meta-analysis of saccharomyces boulardii in adult patients

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World Journal of Gastroenterology 2010年第18期16卷 2202-2222页

作者： Lynne V McFarland Department of Health Services Research and Development Puget Sound Veterans Administration Healthcare System Department of Medicinal Chemistry Box 357610School of PharmacyUniversity of Washington

This article reviews the evidence for efficacy and safety of saccharomyces boulardii(***) for various disease indications in adults based on the peerreviewed,randomized clinical trials and pre-clinical studies from the published medical literature(Medline,Clinical Trial websites and meeting abstracts) between 1976 and *** meta-analysis,only randomized,blinded controlled trials unrestricted by language were ***-clinical studies,volunteer studies and uncontrolled studies were excluded from the review of efficacy and meta-analysis,but included in the systematic *** 31 randomized,placebo-controlled treatment arms in 27 trials(encompassing 5029 study patients),*** was found to be significantly efficacious and safe in 84% of those treatment arms.A meta-analysis found a significant therapeutic efficacy for *** in the prevention of antibiotic-associated diarrhea(AAD)(RR = 0.47,95% CI:0.35-0.63,P < 0.001).In adults,*** can be strongly recommended for the prevention of AAD and the traveler's *** trials also support the use of this yeast probiotic for prevention of enteral nutrition-related diarrhea and reduction of Heliobacter pylori treatment-related *** shows promise for the prevention of *** disease recurrences;treatment of irritable bowel syndrome,acute adult diarrhea,Crohn's disease,giardiasis,human immunodeficiency virus-related diarrhea;but more supporting evidence is recommended for these *** use of *** as a therapeutic probiotic is evidence-based for both efficacy and safety for several types of diarrhea.

关键词： Probiotic Diarrhea saccharomyces boulardii Adult patients Meta-analysis

Role of a probiotic (saccharomyces boulardii) in management and prevention of diarrhoea

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World Journal of Gastroenterology 2006年第28期12卷 4557-4560页

作者： AG Billoo MA Memon SA Khaskheli G Murtaza Khalid Iqbal M Saeed Shekhani Ahson Q Siddiqi Department of Pediatrics Aga Khan UniversityKarachiParkistan Department of Pathology Kharadar General HospitalKarachiParkistan Department of Pediatrics Kharadar General HospitalKarachiParkistan Consultant Pediatrician Kharadar General HospitalKarachiParkistan Medical Director Kharadar General HospitalKarachiParkistan Assistant Professor of Medicine Hamdard UniversityParkistan Director Medical and Regulatory Affairs Hilton Pharma (Pvt.) LtdParkistan

AIM： To assess the efficacy and safety of saccharomyces boulardii （S. boulardii） in acute watery diarrhoea and its role in reducing the frequency of episodes of diarrhoea in subsequent two months. METHODS： Children from 2 mo to 12 years of age, with acute diarrhoea were selected according to inclusion criteria and randomised in S. boulardii group （treated with ORS, nutritional support and S. boulardii, 250 mg bid） and in control group （treated with ORS and nutritional support only）. Active treatment phase was 5 d and each child was followed for two months afterwards. Frequency and consistency of stools as well as safety of drug was assessed on every visit. A comparison of two groups was done in terms of number of diarrhoeal episode in subsequent two months. RESULTS： There were fifty patients in each group. Baseline characteristics such as mean age and the average frequency of stools were comparable in S. boulardii and control group at the time of inclusion in the trial. By d 3 it reduced to 2.7 and 4.2 stools per d respectively and by d 6 it reduced to 1.6 （5. boulardii Group） and 3.3 （control group）. The duration of diarrhoea was 3.6 d in S. boulardii group whereas it was 4.8 d in control group （P = 0.001）. In the following two months, S. boulardii group had a significantly lower frequency of 0.54 episodes as compared to 1.08 episodes in control group. The drug was well accepted and tolerated. There were no reports of the side effects during treatment period CONCLUSION： S. boulardii significantly reduces the frequency and duration of acute diarrhoea. The consistency of stool also improves. The drug is well-tolerated.

关键词： Acute watery diarrhoea Probiotic saccharomyces boulardii Frequency of episodes of diarrhoea Weight gain

saccharomyces boulardii Produces a Factor That Inhibits Mycobacterium intracellulare Burden in Human Macrophages

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Advances in Microbiology 2016年第13期6卷 965-974页

作者： An Bai Michael Weaver Fukai Bao Edward D. Chan Xiyuan Bai Department of Medicine Denver Veterans Affairs Medical Center Denver CO USA Departments of Medicine and Academic Affairs National Jewish Health Denver CO USA Yunnan Key Laboratory for Tropical Infectious Diseases Department of Microbiology and Immunology Kunming Medical University Kunming China Division of Pulmonary Sciences and Critical Care Medicine Department of Medicine University of Colorado School of Medicine Aurora CO USA

Lung disease caused by Non-Tuberculosis Mycobacteria (NTM) is increasing in prevalence. NTM lung disease is notable for poor response to therapy. saccharomyces boulardii is probiotic that can be effective in inflammatory gastrointestinal disease with diverse pathophysiology. The present study investigated the effects of the products of S. boulardii-B508 on burden of NTM-Mycobacterium intracellulare complex in human macrophage infection in vitro. It was found that the supernatant of S. boulardii-B508 inhibited the growth of Mycobacterium intracellulare in human macrophage infection and induced infected cell apoptosis. The data of RT-PCR showed that the products of S. boulardii-B508 inhibited IL-8 expression during M. intracellulare infection in human macrophages due to its effects on NF-kB activation. To the best of our knowledge, this is the first report of effective products of S. boulardii on NTM infection in human macrophage. S. boulardii possesses anti-NTM lung disease properties in human macrophage worthy of further evaluation in clinical studies.

关键词： saccharomyces boulardii Non-Tuberculosis Mycobacteria Nuclear-Factor Kappa B

酵母菌saccharomyces boulardii在健康受试者的免疫药理作用

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国外医学.药学分册 1987年第2期 123-123页

作者：李晓玉

96名健康成人(女43人,男53人),年龄17～75岁,平均46±21岁,经体检证明血象及各项免疫功能

关键词：酵母菌 saccharomyces boulardii 吞噬作用噬菌作用

Effects of saccharomycesboulardiion fecal short-chain fatty acids and microflora in patients on long-term total enteral nutrition

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World Journal of Gastroenterology 2005年第39期11卷 6165-6169页

作者： Stéphane M Schneider Fernand Girard-Pipau Jér(o|^)me Filippi Xavier Hébuterne Dominique Moyse Gustavo Calle Hinojosa Anne Pompei Patrick Rampal Department of Hepato-Gastroenterology and Clinical Nutrition Archet University Hospital NiceFrance Bacteriology Laboratory Archet University Hospital NiceFrance Biostatistician Paris France Department of Hepato-Gastroenterology Princess Grace Hospital Monte-CarloMonaco

AIM： To assess the effects of Sb on fecal flora and shortchain fatty acids （SCFA） in patients on long-term TEN. METHODS： Ten patients （3 females, 7 males, 59±5.5 years）, on TEN for a median of 13 mo （1-125）, and 15 healthy volunteers （4 females, 11 males, 32±2.0 years） received Sb （0.5 g bid PO） for 6 d. Two stool samples were taken before, on the last 2 d and 9-10 d after treatment, for SCFA measurement and for culture and bacterial identification. Values （mean4-SE） were compared using sign tests and ANOVA. RESULTS： Fecal butyrate levels were lower in patients （10.1±2.9 mmol/kg） than in controls （19.2±3.9, P= 0.02）. Treatment with Sb increased total fecal SCFA levels in patients （150.2＋27.2 vs 107.5±18.2 mmol/kg, P= 0.02） but not in controls （129.0±28.6 vs 113.0±15.2 mmol/kg, NS）. At the end of treatment with Sb, patients had higher fecal butyrate（16.0±4.4 vs 10.1 [2.9] mmol/kg, P= 0.004）. Total SCFAs remained high 9 d after treatment was discontinued. Before the treatment, the anaerobe to aerobe ratio was lower in patients compared to controls （2.4±2.3 vs 69.8±1.8, P= 0.003）. There were no significant changes in the fecal flora of TEN patients. CONCLUSION： Sb-induced increase of fecal SCFA concentrations （especially butyrate） may explain the preventive effects of this yeast on TEN-induced diarrhea.

关键词： Enteral nutrition Diarrhea saccharomyces boulardii Short-chain fatty acids Intestinal microbiota

Probiotics for gastrointestinal disorders: Proposed recommendations for children of the Asia-Pacific region

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World Journal of Gastroenterology 2017年第45期23卷 7952-7964页

作者： Donald Cameron Quak Seng Hock Musal Kadim Neelam Mohan Eell Ryoo Bhupinder Sandhu Yuichiro Yamashiro Chen Jie Hans Hoekstra Alfredo Guarino Department of Gastroenterology and Clinical Nutrition Royal Children’s Hospital Yong Loo Lin School of Medicine National University of Singapore Child Health Department Cipto Mangunkusumo HospitalUniversity of Indonesia Department of Pediatric Gastroenterology Hepatology And Liver Transplantation Department of Pediatrics Gachon UniversityGil Gachon Children’s Hosptial Department of Paediatric Gastroenterology Royal Hospital for Children Probiotics Research Laboratory Juntendo University Graduate School of Medicine The Children’s Hospital Zhejiang University School of Medicine Department of Pediatrics Hieronymus Bosch Hospital Unit of Pediatrics Infectious Diseases and Clinical Nutrition of the Department of Translational Medical Science-Section of Pediatrics University of Naples Federico II

Recommendations for probiotics are available in several regions. This paper proposes recommendations for probiotics in pediatric gastrointestinal diseases in the Asia-Pacific region. Epidemiology and clinical patterns of intestinal diseases in Asia-Pacific countries were discussed. Evidence-based recommendations and randomized controlled trials in the region were revised. Cultural aspects,health management issues and economic factors were also considered. Final recommendations were approved by applying the Likert scale and rated using the GRADE system. saccharomyces boulardii CNCM I-745(Sb) and Lactobacillus rhamnosus GG(LGG) were strongly recommended as adjunct treatment to oral rehydration therapy for gastroenteritis. Lactobacillus reuteri could also be considered. Probiotics may be considered for prevention of(with the indicated strains): antibiotic-associated diarrhea(LGG or Sb); Clostridium difficile-induced diarrhea(Sb); nosocomial diarrhea(LGG); infantile colic(L reuteri) and as adjunct treatment of Helicobacter pylori(Sb and others). Specific probiotics with a history of safe use in preterm and term infants may be considered in infants for prevention of necrotizing enterocolitis. There is insufficient evidence for recommendations in other conditions. Despite a diversity of epidemiological,socioeconomical and health system conditions,similar recommendations apply well to Asia pacific countries. These need to be validated with local randomized-controlled trials.

关键词： Lactobacillus rhamnosus Gastroenteritis Guidelines Probiotics Children Recommendations Asia-Pacific saccharomyces boulardii