检索结果-南通市图书馆

synthetic biology approaches for improving the specificity and efficacy of cancer immunotherapy

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2024年第5期21卷 436-447页

作者： Bo Zhu Hang Yin Di Zhang Meiling Zhang Xiaojuan Chao Luca Scimeca Ming-Ru Wu Department of Liver Surgery Center of Hepato-Pancreato-Biliary SurgeryInstitute of Precision MedicineThe First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China. Department of Cancer Immunology and Virology Dana-Farber Cancer InstituteBostonMA 02215USA. Department of Immunology Harvard Medical SchoolBostonMA 02115USA. Drug Safety Research&Evaluation Takeda Pharmaceuticals International CompanyCambridgeMA 02139USA. Medical Research Institute Guangdong Provincial People’s HospitalSouthern Medical UniversityGuangzhou 510080China.

Immunotherapy has shown robust efficacy in treating a broad spectrum of hematological and solid *** the transformative impact of immunotherapy on cancer treatment,several outstanding challenges *** challenges include on-target off-tumor toxicity,systemic toxicity,and the complexity of achieving potent and sustainable therapeutic *** biology has emerged as a promising approach to overcome these obstacles,offering innovative tools for engineering living cells with customized *** review provides an overview of the current landscape and future prospects of cancer immunotherapy,particularly emphasizing the role of synthetic biology in augmenting its specificity,controllability,and *** delineate and discuss two principal synthetic biology strategies:those targeting tumor surface antigens with engineered immune cells and those detecting intratumoral disease signatures with engineered gene *** review concludes with a forwardlooking perspective on the enduring challenges in cancer immunotherapy and the potential breakthroughs that synthetic biology may contribute to the field.

关键词： synthetic biology Cancer immunotherapy Gene circuit Gene therapy Adoptive cell therapy.

synthetic biology identifies the minimal gene set required for paclitaxel biosynthesis in a plant chassis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2023年第12期16卷 1951-1961页

作者： Youjun Zhang Lorenz Wiese Hao Fang Saleh Alseekh Leonardo Perez de Souza Federico Scossa John Molloy Mathias Christmann Alisdair R.Fernie Max-Planck-Institut fur Molekulare Pflanzenphysiologie Am Muhlenberg 114476 Potsdam-GolmGermany Center of Plant Systems biology and Biotechnology 4000 PlovdivBulgaria Institute of Chemistry and Biochemistry Freie Universitat BerlinTakustraBe 314195 BerlinGermany Department of Biomolecular Systems Max Planck Institute of Colloids and Interfaces14476 PotsdamGermany Research Center for Genomics and Bioinformatics(CREA-GB) Via Ardeatina 54600178 RomeItaly

The diterpenoid paclitaxel(Taxol)is a chemotherapy medication widely used as a first-line treatment against several types of solid *** supply of paclitaxel from natural sources is ***,missing knowledge about the genes involved in several specific metabolic steps of paclitaxel biosynthesis has rendered it difficult to engineer the full *** this study,we used a combination of transcriptomics,cell biology,metabolomics,and pathway reconstitution to identify the complete gene set required for the heterologous production of *** identified the missing steps from the current model of paclitaxel biosynthesis and confirmed the activity of most of the missing enzymes via heterologous expression in Nicotiana ***,we identified a new C4β-C20 epoxidase that could overcome the first bottleneck of metabolic *** used both previously characterized and newly identified oxomutases/epoxidases,taxane 1β-hydroxylase,taxane 9aα-hydroxylase,taxane 9α-dioxygenase,and phenylalanine-CoA ligase,to successfully biosynthesize the key intermediate baccatin Ill and to convert baccatin Ill into paclitaxel in *** combination,these approaches establisha metabolic route to taxoidbiosynthesis and provide insights into the unique chemistry that plants use to generate complex bioactive metabolites.

关键词： paclitaxel biosynthesis synthetic biology baccatin Ill biosynthesis Taxus

synthetic biology techniques to tackle heavy metal pollution and poisoning

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

synthetic and Systems Biotechnology 2022年第3期7卷 841-846页

作者： Adithi Somayaji Soumodeep Sarkar Shravan Balasubramaniam Ritu Raval Department of Biotechnology Manipal Institute of TechnologyManipal Academy of Higher EducationManipalIndia Manipal BioMachines Manipal Institute of TechnologyManipal Academy of Higher EducationManipalIndia

The requirement for natural resources and energy increases continually with the increase in *** inevitable result of this is soil,water,and air pollution with diverse pollutants,including heavy *** biology involves using modular,interchangeable biological parts,devices in standard chassis or whole organisms to achieve a programmed result that can be quantified and optimized till it meets the required *** makes synthetic biology techniques very popular to tackle pressing global issues such as heavy metal *** review aimed to highlight various advancements as well as benefits,risks,and problems in synthetic biology techniques for detection,bioaccumulation,and biosorption of various heavy metals using engineered *** found that while such an approach is cost-effective,accessible,and efficient,there are several inherent technological and ethical issues including but not limited to metabolic burden and consequences of use of genetically modified organisms *** these hurdles will probably take time and innumerable conversations,and should be done through education and a culture of responsible research,rather than enforcing restrictions on the development of synthetic biology.

关键词： Heavy metals Biosensors Bioremediation synthetic biology Responsible research

synthetic biology in the UK-An outline of plans and progress

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

synthetic and Systems Biotechnology 2016年第4期1卷 243-257页

作者： L.J.Clarke R.I.Kitney UK synthetic biology Leadership Council UK Department of BioEngineering Imperial CollegeUK Faculty of Life Sciences University of ManchesterUK BionerG UK EPSRC National Centre for synthetic biology and Innovation UK Institute of Systems and synthetic biology UK BioMedical Systems Engineering Imperial CollegeUK BioMedical Systems EngineeringImperial CollegeUK

synthetic biology is capable of delivering new solutions to key challenges spanning the bioeconomy,both nationally and *** this significant potential and the associated need to facilitate its translation and commercialisation the UK government commissioned the production of a national synthetic biology Roadmap in 2011,and subsequently provided crucial support to assist its *** infrastructural investments have been made,and important strides made towards the development of an effectively connected community of practitioners and interest groups.A number of synthetic biology Research Centres,DNA Synthesis Foundries,a Centre for Doctoral Training,and an Innovation Knowledge Centre have been established,creating a nationally distributed and integrated network of complementary facilities and *** UK synthetic biology Leadership Council published a UK synthetic biology Strategic Plan in 2016,increasing focus on the processes of translation and *** 50 start-ups,SMEs and larger companies are actively engaged in synthetic biology in the UK,and inward investments are starting to *** these initiatives provide an important foundation for stimulating innovation,actively contributing to international research and development partnerships,and helping deliver useful benefits from synthetic biology in response to local and global needs and challenges.

关键词： synthetic biology Engineering biology Biodesign Roadmap Responsible Research and Innovation(RRI) Innovation and Knowledge Centre(IKC) synthetic biology Leadership Council(SBLC) Bioeconomy

An international comprehensive benchmarking analysis of synthetic biology in China from 2015 to 2020

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Engineering 2022年第8期35卷 211-226页

作者： Meiru Jiang Cong Chen Tao Chen Chao Zhao Zhiwen Wang Frontier Science Center for synthetic biology and Key Laboratory of Systems Bioengineering(Ministry of Education) SynBio Research PlatformCollaborative Innovation Center of Chemical Science and Engineering(Tianjin)School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China Center for Biosafety Research and Strategy Tianjin UniversityTianjin 300072China

As a new interdisciplinary field,synthetic biology has led to valuable innovations in the fields of medicine,chemistry,agriculture,energy and *** this paper,we systematically review the development status of global synthetic biology in the past six years,and make an in-depth benchmarking analysis of the field in *** the aid of Scopus and SciVal,we analyze the scholarly output of synthetic biology in the world and individual countries,including publication distribution,popular journals and eminent ***,the research focus and concepts,citation impact and collaborations are also examined using numerical index methods such as the field-weighted citation impact(FWCI)and relative activity index(RAI),showing the differences between data more *** study aims to offer a comprehensive understanding of the research status of synthetic biology in China and the world,offering a benchmarked overview of the results as a reference to guide the development of this field in the future.

关键词： synthetic biology Scopus SciVal Output Citation impact Collaboration

Current advances of biocontainment strategy in synthetic biology

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Engineering 2023年第4期56卷 141-151页

作者： Xueying Zhu Zhaoyang Zhang Bin Jia Yingjin Yuan Frontier Science Center for synthetic biology and Key Laboratory of Systems Bioengineering(Ministry of Education) School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China

synthetic biotechnology has led to the widespread application of genetically modified organisms(GMOs)in biochemistry, bioenergy, and therapy. However, the uncontrolled spread of GMOs may lead to genetic contamination by horizontal gene transfer, resulting in unpredictable biosafety risks. To deal with these challenges, many effective methods have been developed for biocontainment. In this article, we summarize and discuss recent advances in biocontainment strategies from three aspects: DNA replication, transcriptional regulation, and protein translation. We also briefly introduce the efforts in the biocontainment convention, such as the recent publication of the Tianjin Biosecurity Guidelines for the Code of Conduct for Scientists.

关键词： Genetically modified organisms(GMOs) Biocontainment Biosecurity synthetic biology Molecular biology Biotechnology

synthetic biology： a new approach to stud bioloaical pattern formation

在线全文

学校读者我要写书评

暂无评论

Frontiers of Electrical and Electronic Engineering in China 2013年第4期8卷 246-252页

作者： Chenli Liu Xiongfei Fu Jian-Dong Huang Department of Biochemistry The University of Hong Kong Hong Kong China Department of Physics The University of Hong Kong Hong Kong China Center for synthetic biology Engineering Research Guangzhou Institute of Advanced Technology Chinese Academy of Sciences Guangzhou 511458 China

The principles and molecular mechanisms underlying biological pattern formation are difficult to elucidate in most cases due to the overwhelming physiologic complexity associated with the natural context. The understanding of a particular mechanism, not to speak of underlying universal principles, is difficult due to the diversity and uncertainty of the biological systems. Although current genetic and biochemical approaches have greatly advanced our understanding of pattern formation, the progress mainly relies on experimental phenotypes obtained from time- consuming studies of gain or loss of function mutants. It is prevailingly considered that synthetic biology will come to the application age, but more importantly synthetic biology can be used to understand the life. Using periodic stripe pattern formation as a paradigm, we discuss how to apply synthetic biology in understanding biological pattern formation and hereafter foster the applications like tissue engineering.

关键词： Genetic Circuit Pattern Formation Periodic Pattern synthetic Biologist synthetic biology

Efficient production of chemicals from microorganism by metabolic engineering and synthetic biology

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Engineering 2021年第2期34卷 14-28页

作者： Yang Zhang Jing Yu Yilu Wu Mingda Li Yuxuan Zhao Haowen Zhu Changjing Chen Meng Wang Biqiang Chen Tianwei Tan National Energy R&D Center for Biorefinery Beijing University of Chemical TechnologyBeijing 100029China

The use of traditional chemical catalysis to produce chemicals has a series of drawbacks,such as high dependence on fossil resources,high energy consumption,and environmental *** the development of synthetic biology and metabolic engineering,the use of renewable biomass raw materials for chemicals synthesis by constructing efficient microbial cell factories is a green way to replace traditional chemical catalysis and traditional microbial *** review mainly summarizes several types of bulk chemicals and high value-added chemicals using metabolic engineering and synthetic biology strategies to achieve efficient microbial *** addition,this review also summarizes several strategies for effectively regulating microbial cell *** strategies can achieve the coupling balance of material and energy by regulating intracellular material metabolism or energy metabolism,and promote the efficient production of target chemicals by microorganisms.

关键词： Chemicals synthetic biology Metabolic regulation Microbial cell factory

synthetic biology:Recent progress,biosafety and biosecurity concerns,and possible solutions

在线全文

学校读者我要写书评

暂无评论

Journal of Biosafety and Biosecurity 2019年第1期1卷 22-30页

作者： Fangzhong Wang Weiwen Zhang Center for Biosafety Research and Strategy Tianjin UniversityTianjinPR China Laboratory of synthetic Microbiology School of Chemical Engineering and TechnologyTianjin UniversityTianjinPR China Key Laboratory of Systems Bioengineering(Ministry of Education) Tianjin UniversityTianjinPR China SynBio Research Platform Collaborative Innovation Center of Chemical Science and Engineering(Tianjin)PR China

synthetic biology is a new interdisciplinary research area that uses engineering principles as guidelines for biological *** research goals to modify existing biological systems or to create new ones,the recent applications of synthetic biology have expanded approaches and tools for conventional biological *** this article,we first briefly review the development and progress of synthetic biology over the past *** the contributions of synthetic biology to basic life science research,human health,environmental protection,and even economic growth have been widely observed,potential biosafety,biosecurity,and ethical risks related to synthetic biology have also emerged in recent years as technology becomes less expensive,more mature,and more *** provide a brief assessment of the risks associated with the possible misuse or abuse of this technology in various areas and discuss concerns from three points of view:biosafety,biosecurity risks,and ***,to address challenges arising from the rapid progress of synthetic biology,technical,ethical,and regulatory measures were developed or discussed in recent years,including laboratory level precautionary measures for biosafety and biosecurity related to synthetic biology(such as genetic safeguards and firewalls),ethical codes of conduct for biological scientists,and regulations or oversight rules from personal,national,and international perspectives.A brief summary of these efforts is provided.

关键词： synthetic biology Biosafety Biosecurity Ethics Genetic firewall Genetic safeguard Code of conduct Governance regulation