检索结果-南通市图书馆

脑内血肿国际外科治疗试验(stich)中自发性幕上脑内血肿患者早期手术与保守治疗的疗效对比随机试验

世界核心医学期刊文摘（神经病学分册） 2005年第6期1卷 8-9页

作者： Mendelow A.D. Gregson B.A. Fernandes H.M. 黄卫东 Department of Neurosurgery Newcastle General Hospital Newcastle upon Tyne NE4 6BE United Kingdom

Background Spontaneous supratentorial intracerebral haemorrhage accounts for 20% of all stroke- related sudden neurological deficits, has the highest morbidity and mortality of all stroke, and the role of surgery remains controversial. We undertook a prospective randomised trial to compare early surgery with initial conservative treatment for patients with intracerebral haemorrhage. Methods A parallel- group trial design was used. Early surgery combined haematoma evacuation (within 24 h of randomisation) with medical treatment. Initial conservative treatment used medical treatment, although later evacuation was allowed if necessary. We used the eight- point Glasgow outcome scale obtained by postal questionnaires sent directly to patients at 6 months follow- up as the primary outcome measure. We divided the patients into good and poor prognosis groups on the basis of their clinical status at randomisation. For the good prognosis group, a favourable outcome was defined as good recovery or moderate disability on the Glasgow outcome scale. For the poor prognosis group, a favourable outcome also included the upper level of severe disability. Analysis was by intention to treat. Findings 1033 patients from 83 centres in 27 countries were randomised to early surgery (503) or initial conservative treatment (530). At 6 months, 51 patients were lost to follow- up, and 17 were alive with unknown status. Of 468 patients randomised to early surgery, 122 (26% ) had a favourable outcome compared with 118 (24% ) of 496 randomised to initial conservative treatment (odds ratio 0.89 [95% CI 0.66- 1.19], p=0.414); absolute benefit 2.3% (- 3.2to 7.7), relative benefit 10% (- 13 to 33). Interpretation Patients with spontaneous supratentorial intracerebral haemorrhage in neurosurgical units show no overall benefit from early surgery when compared with initial conservative treatment.

关键词：脑内血肿 stich 随机试验中度残疾保守治疗组预后良好邮寄调查临床状况 Glasgow 神经损害

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：