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Prognostic Factors for Survival of stage ib Upper Lobe Non-small Cell Lung Cancer Patients: A Retrospective Study in Shanghai, China

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Chinese Journal of Cancer Research 2011年第4期23卷 265-270页

作者： Wen-li Wang Yang Shen-tu1 Zhi-qiang Wang Shanghai Lung Cancer Center Shanghai Chest Hospital School of Medicine Shanghai Jioo Tong University Shanghai 200030 China Center for Chronic Disease School of Medicine University of Queensland Health Sciences Building Royal Brisbane & Women's HospitalHerston QLD 4029 Australia

Objective: To identify clinical and pathologic factors that were associated with the survival of stage ib upper lobe non-small cell lung cancer (NSCLC) patients. Methods: A retrospective study of 147 subjects who had undergone curative resection for stage ib upper lobe NSCLC was performed. Patients who had received any adjuvant or neo-adjuvant chemotherapy were excluded. Survival function curves were estimated using the Kaplan-Meier procedure. Crude and adjusted hazard ratios (HRs) of potential prognostic factors were estimated using Cox proportional hazards models. Results: Five factors, including age, tumor size, histologic grade of differentiation, number of removed superior mediastinal lymph node stations and presence of visceral pleura invasion, were significantly and independently associated with mortality risk. Adjusted HRs were 2.6 [95% confidence interval (95% CI): 1.1?6.5] and 4.6 (95% CI: 1.9?11) for those aged 58?68 years and those >68 years, respectively, relative to those aged 5 cm (vs ?3.0 cm) were 2.3 (95% CI: 1.1?4.9) and 4.3 (95% CI: 1.9?10), respectively. The presence of visceral pleura invasion also increased the risk of mortality (HR=4.0, 95% CI: 1.3?12). Conclusion: Advanced age, larger tumor size, poorly differentiated histology, smaller number of removed superior mediastinal lymph node stations, and presence of visceral pleura invasion were associated with poor survival of surgically treated stage ib upper lobe NSCLC patients.

关键词： Non-small cell lung cancer stage ib Prognosis Lymphadenectomy

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stage ib, HA AND PROXIMAL Iib, CARCINOMA OF THE UTERINE CERVIX, TREATED BY IRRADIATION ALONE OR IN COMBINATION WITH SURGERY

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Chinese Journal of Cancer Research 1990年第1期2卷 73-78页

作者：任传富 J M Bachaud M Delannes F Izar P Martel N J Daly Division of Radiation Therapy Center Claudius Regaud Toulouse Cedex France Department of Radiation Therapy General Hospital of Tianjin Medical College of Tianjin Division of Radiation Therapy Center Claudius Regaud Toulouse Cedex France Division of Surgery Center Claudius Regaud Toulouse Cedex France Division of Radiation Therapy Center Claudius Regaud Toulouse Cedex Francehis is a report of a nonrandomized comparison of treatment results of 139 patients with stage IB HA and proximal IIB carcinoma of the uterine cervix treated by radiation alone and 113 treated with a combination of radiation and surgery. The five-year tumor free acturial survival for the patients with stage IB either with irradiation alone (RT) or combined with surgery (RS) was approximately 87%. For stage Ⅱ the tumor free actuarial five-year survival 79% with patients of RS and 76% with RT. In the 113 patients treated with RS there were 18 (16%). In the 139 patients treated by RT there were 18 (13%) recurrences of pelvic 4 local recurrences 11 combined with parametrial and free parametrial recurrences. There was no significant difference in the survival and recurrence rate of the patients treated with either method. Major complications were comparable in both groups (RT approximately 25% and RS approximately 10%) but 2/3 of those complications recovered without sequelae. The most frequent minor complication in the patients treated with RT was rectosigmoiditis.

This is a report of a nonrandomized comparison of treatment results of 139 patients with stage ib, HA and proximal Iib carcinoma of the uterine cervix treated by radiation alone and 113 treated with a combination of radiation and surgery. The five-year tumor free acturial survival for the patients with stage ib either with irradiation alone (RT) or combined with surgery (RS) was approximately 87%. For stage Ⅱ the tumor free actuarial five-year survival 79% with patients of RS, and 76% with RT. In the 113 patients treated with RS there were 18 (16%). In the 139 patients treated by RT there were 18 (13%) recurrences of pelvic, 4 local recurrences, 11 combined with parametrial, and free parametrial recurrences. There was no significant difference in the survival and recurrence rate of the patients treated with either method. Major complications were comparable in both groups (RT approximately 25% and RS approximately 10%), but 2/3 of those complications recovered without sequelae. The most frequent minor complication in the patients treated with RT was rectosigmoiditis.

关键词： TREATED BY IRRADIATION ALONE OR IN COMBINATION WITH SURGERY stage ib CARCINOMA OF THE UTERINE CERVIX

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