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Journal of Integrative Plant Biology 2022年第10期64卷 1952-1965页

作者： Jie Qian Min Zheng Lingyu Wang Yu Song Jiawen Yan Yi‐Feng Hsu School of Life Sciences Southwest UniversityChongqing 400715China

Faithful DNA replication is one of the most essential processes in almost all living organisms.However,the proteins responsible for organellar DNA replication are still largely unknown in plants.Here,we show that the two mitochondriontargeted single-stranded DNA-binding(ssb)proteins ssb1 and ssb2 directly interact with each other and act as key factors for mitochondrial DNA(mt DNA)maintenance,as their single or double loss-of-function mutants exhibit severe germination delay and growth retardation.The mt DNA levels in mutants lacking ssb1 and/or ssb2 function were two-to four-fold higher than in the wild-type(WT),revealing a negative role for ssb1/2 in regulating mt DNA replication.Genetic analysis indicated that ssb1 functions upstream of mitochondrial DNA POLYMERASE IA(POLIA)or POLIB in mt DNA replication,as mutation in either gene restored the high mt DNA copy number of the ssb1-1 mutant back to WT levels.In addition,ssb1 and ssb2 also participate in mitochondrial genome maintenance by influencing mt DNA homologous recombination(HR).Additional genetic analysis suggested that ssb1 functions upstream of ORGANELLAR SINGLE-STRANDED DNABINDING PROTEIN1(OSB1)during mt DNA replication,while ssb1 may act downstream of OSB1and MUTS HOMOLOG1 for mt DNA HR.Overall,our results yield new insights into the roles of the plant mitochondrion-targeted ssb proteins and OSB1 in maintaining mt DNA stability via affecting DNA replication and DNA HR.

关键词： Arabidopsis mitochondria mtDNA replication mtDNA recombination ssb

Anti-SSA/ssb-negative primary Sjögren’s syndrome presenting with hypokalemia:A case report

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World Journal of Emergency Medicine 2022年第2期13卷 149-151页

作者： Hai-yan Tu Shu-ling Yue Li-jun Mou Department of Nephrology the Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310009China Guangzhou KingMed Center for Clinical Laboratory Co.Ltd. Guangzhou 510320China

Dear editor,Here we report a rare case of a patient presented with repeated hypokalemia and metabolic acidosis secondary to primary Sjögren’s syndrome(pSS).Though no significantly raised titers of anti-SSA/ssb antibodies was detected in our case,minor salivary gland biopsy,kidney biopsy and positive Schirmer’s test confirmed the diagnosis of pSS.

关键词： diagnosis ssb SSA

ssb peptide and DNA co-immunization induces inhibition of anti-dsDNA antibody production in rabbits

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Chinese Medical Journal 2008年第3期121卷 227-230页

作者： DING Min ZHANG Jian-zhong Department of Dermatology Peking University People's HospitalBeijing 100044 China

Background Patients with systemic lupus erythematosus often have various autoantibodies. The relationship between these antibodies is still poorly understood. The aim of the present study was to observe the anti-ssb antibody and anti-dsDNA antibody production profiles following immunization with synthetic ssb peptide alone, DNA alone or co-immunization with these two antigens. Methods ssb 214-225 aa peptide was synthesized by organic chemistry solid-phase peptide synthesis. Rabbits were immunized with the following antigens： synthetic ssb peptide linked with keyhole limpet hemocyanin （KLH）, DNA, ssb plus dsDNA, KLH and PBS. Antibodies were measured by ELISA. Histopathology and direct immufluorescence assays were also applied. Results Anti-ssb and anti-dsDNA antibodies were produced following immunization with ssb peptide and DNA respectively. The level of ssb antibody in the co-immunization group was higher than that of the ssb peptide immunization group. The level of anti-dsDNA antibody in the co-immunization group was, however, lower than that in the DNA immunization group. Meanwhile, the level of anti-ssb antibody was higher than that of anti-DNA antibody in the co-immunization group. No morphological or immunological abnormalities were found in the heart, liver, kidney, spleen or skin tissues. Conclusion Inhibition of anti-dsDNA-antibody was induced by co-immunization with synthesized ssb peptide and DNA, which might explain, at least partly, the mild disease in some LE subsets associated with ssb antibody.

关键词： lupus erythematosus antibody ssb dsDNA immunization

Novel full-duplex ssb WDM-RoF system with SLM technique for decreasing PAPR

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Optoelectronics Letters 2013年第4期9卷 309-312页

作者：肖要强陈林李凡何海珍 Key Laboratory for Micro-/Nano-Optoelectronic Devices of Ministry of Education College of Information Science and EngineeringHunan University

A novel full-duplex single-sideband (ssb) wavelength division multiplexing radio over fiber (WDM-RoF) system with selected mapping (SLM) technique for decreasing peak-to-average power ratio (PAPR) is proposed in this paper. At the central office (CO), the generated ssb signal carrying 10 Gbit/s 16-ary quadrature amplitude modulation orthogonal frequency division multiplexing (16QAM-OFDM) downstream signal with SLM technique is sent to the base station, and 60 GHz ssb optical signal carrying 10 Gbit/s 16QAM-OFDM upstream signal is sent back to CO utilizing the wavelength-reuse technology. Simulation results show the proposed method for PAPR reduction can effectively improve the sensitivity of receiver, and the power penalty of the 16QAM-OFDM downlink (uplink) signal is about 2 dB (3 dB) at BER of 1×10-3 after 42 km standard single-mode fiber (SSMF) transmission.

关键词： SLM技术 PAPR ssb F系统全双工 TEC 正交频分复用标准单模光纤

干燥综合征患者唾液流率与口干症状的一致性分析

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口腔医学研究 2023年第8期39卷 751-754页

作者：卫明慧汪苑苑汪玉红王新文杜望磊口颌系统重建与再生全国重点实验室国家口腔疾病临床医学研究中心陕西省口腔疾病临床医学研究中心第四军医大学口腔医院口腔黏膜病科陕西西安710032 空军军医大学第一附属医院临床免疫科陕西西安710032

目的:分析干燥综合征(Sjögren's syndrome,SS)患者口干症状与静息唾液流率下降的一致性,并探讨影响静息唾液流率的相关因素。方法:采集151例确诊SS患者的临床资料,包括口干症状、静息唾液流率、血液学指标及临床病史等,应用Kappa一致性... 详细信息

目的:分析干燥综合征(Sjögren's syndrome,SS)患者口干症状与静息唾液流率下降的一致性,并探讨影响静息唾液流率的相关因素。方法:采集151例确诊SS患者的临床资料,包括口干症状、静息唾液流率、血液学指标及临床病史等,应用Kappa一致性检验和Spearman相关性检验进行统计学分析。结果:干燥综合征患者中唾液流率下降与口干症有极低的一致性,进一步分析发现,静息唾液流率下降与SS病程、ANA抗体滴度、IgM水平及自身免疫性肝病呈正相关关系。结论:SS患者唾液流率下降与口干症状缺乏一致表现,静息唾液流率虽然对SS有一定的预测及监控价值,但受到多种因素影响可能出现波动,了解其影响因素并实施定向干预,有助于SS患者的口腔健康管理。

关键词：干燥综合征静息唾液流率 IgM 口干自身免疫性肝病 SSA ssb

Sea State Bias Estimation with Least Absolute Shrinkage and Selection Operator(LASSO)

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Journal of Ocean University of China 2018年第5期17卷 1019-1025页

作者： ZHONG Guoqiang LIU Benxiu GUO Yingting MIAO Hongli College of Computer Science and Technology Ocean University of China

With the sea-level rising,the measurement of sea surface height(SSH) is attracting more and more attention in the area of oceanography.Satellite radar altimeter is usually used to measure the SSH.However,deviation between the measured value and the actual one always exists.Among others,the sea state bias(ssb) is a main reason to cause the deviation.In general,one needs to estimate ssb first to correct the measured SSH.Currently,existing ssb estimation methods more or less have shortcomings,such as with many parameters,high prediction error and long training time.In this paper,we introduce an effective and efficient linear model called LASSO to the ssb estimation.The LASSO algorithm minimizes the residual sum of squares under the condition that the sum of the absolute values of each coefficient is less than a certain constant.In the implementation of LASSO,we use the significant wave height and wind speed to fit the LASSO model.Hence,the applied model has only 3 parameters,corresponding to the two inputs and a bias.Experimental results on the data of JASON-2,JASON-3,T/P and HY-2 radar altimetry show that LASSO performs better than geophysical data records(GDR) and ordinary least squares(OLS) estimator.Moreover,from the running time,we can see that LASSO is very efficient.

关键词：评价方法偏爱操作员收缩训练时间线性模型雷达高度表 ssb

Numerical Analysis of Electrically Tunable Delay-Line with an ssb Modulator

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光学学报 2003年第S1期23卷 619-620页

作者： Tetsuya Kawanishi Masayuki Izutsu Communications Research Laboratory 4-2-1 Nukui-kita Koganei Tokyo 184-8795 JapanCommunications Research Laboratory 4-2-1 Nukui-kita Koganei Tokyo 184-8795 Japan

By using an optical system simulator, we investigated the tunable delay-line with an optical ssb modulator and an optical fiber loop, where the delay can be controlled by the electric signal fed to the modulator.

关键词： ssb be of Numerical Analysis of Electrically Tunable Delay-Line with an ssb Modulator were FBG line into with

BOTTOM BARYONS(B=-1)∧_b^0=udb,≡_b^0=usb,≡_b^-=dsb,Ω_b^-=ssb

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Chinese Physics C 2014年第9期38卷 1536-1543页

作者： K.A.Olive K.Agashe C.Amsler M.Antonelli J.-F.Arguin D.M.Asner H.Baer H.R.Band R.M.Barnett T.Basaglia C.W.Bauer J.J.Beatty V.I.Belousov J.Beringer G.Bernardi S.Bethke H.Bichsel O.Biebe E.Blucher S.Blusk G.Brooijmans O.Buchmueller V.Burkert M.A.Bychkov R.N.Cahn M.Carena A.Ceccucci A.Cerr D.Chakraborty M.-C.Chen R.S.Chivukula K.Copic G.Cowan O.Dahl G.D'Ambrosio T.Damour D.de Florian A.de Gouvea T.DeGrand P.de Jong G.Dissertor B.A.Dobrescu M.Doser M.Drees H.K.Dreiner D.A.Edwards S.Eidelman J.Erler V.V.Ezhela W.Fetscher B.D.Fields B.Foster A.Freitas T.K.Gaisser H.Gallagher L.Garren H.-J.Gerber G.Gerbier T.Gershon T.Gherghetta S.Golwala M.Goodman C.Grab A.V.Gritsan C.Grojean D.E.Groom M.Grnewald A.Gurtu T.Gutsche H.E.Haber K.Hagiwara C.Hanhart S.Hashimoto Y.Hayato K.G.Hayes M.Heffner B.Heltsley J.J.Hernandez-Rey K.Hikasa A.Hocker J.Holder A.Holtkamp J.Huston J.D.Jackson K.F.Johnson T.Junk M.Kado D.Karlen U.F.Katz S.R.Klein E.Klempt R.V.Kowalewski F.Krauss M.Kreps B.Krusche Yu.V.Kuyanov Y.Kwon O.Lahav J.Laiho P.Langacker A.Liddle Z.Ligeti C.-J.Lin T.M.Liss L.Littenberg K.S.Lugovsky S.B.Lugovsky F.Maltoni T.Mannel A.V.Manohar W.J.Marciano A.D.Martin A.Masoni J.Matthews D.Milstead P.Molaro K.Monig F.Moortgat M.J.Mortonson H.Murayama K.Nakamura M.Narain P.Nason S.Navas M.Neubert P.Nevski Y.Nir L.Pape J.Parsons C.Patrignani J.A.Peacock M.Pennington S.T.Petcov Kavli IPMU A.Piepke A.Pomarol A.Quadt S.Raby J.Rademacker G.Raffel B.N.Ratcliff P.Richardson A.Ringwald S.Roesler S.Rolli A.Romaniouk L.J.Rosenberg J L.Rosner G.Rybka C.T.Sachrajda Y.Sakai G.P.Salam S.Sarkar F.Sauli O.Schneider K.Scholberg D.Scott V.Sharma S.R.Sharpe M.Silari T.Sjostrand P.Skands J.G.Smith G.F.Smoot S.Spanier H.Spieler C.Spiering A.Stahl T.Stanev S.L.Stone T.Sumiyoshi M.J.Syphers F.Takahashi M.Tanabashi J.Terning L.Tiator M.Titov N.P.Tkachenko N.A.Tornqvist D.Tovey G.Valencia G.Venanzoni M.G.Vincter P.Vogel A.Vogt S.P.Wakely W.Walkowiak C.W.Walter D.R.Ward G.Weiglein D.H.Weinberg E.J.Weinberg M.White L.R.Wiencke C.G.Wohl L.Wolfenstein J.Womersley C.L. University of Minnesota School of Physics and Astronomy116 Church St.S.E.MinneapolisMN 55455USA University of Maryland Department of PhysicsCollege ParkMD 20742-4111USA Albert Einstein Center for Fundamental Physics Universitat BernCH-3012 BernSwitzerland Lab.Nazionali di Frascati dell'INFN CP 13via E.Fermi40I-00044 Frascati(Roma)Italy Departement de physique Universite de MontrealC.P.6128succ.centre-villeMontreal(Quebec) H3C 3J7Canada Pacific Northwest National Laboratory 902 Battelle BoulevardRichlandWA 99352USA Department of Physics and Astronomy University of OklahomaNormanOK 73019USA Department of Physics University of WisconsinMadisonWI 53706USA Physics Division Lawrence Berkeley National Laboratory1 Cyclotron RoadBerkeleyCA 94720USA CERN European Organization for Nuclear ResearchCH-1211 Geneve 23Switzerland Department of Physics The Ohio State University191 W.Woodruff Ave.ColumbusOH 43210 COMPAS Group Institute for High Energy PhysicsRU- 142284ProtvinoRussia LPNHE IN2P3-CNRS et Universites de Paris 6 et 7F-75252 ParisFrance Max-Planck-Institute of Physics 80805 MunichGermany Department of Physics University of WashingtonSeattleWA 98195USA Ludwig-Maximilians-Universitat Fakultdt für PhysikSchellingstr.4D-80799 MünchenGermany Enrico Fermi Institute and Department of Physics University of ChicagoChicagoIL 60637-1433USA Department of Physics Syracuse UniversitySyracuseNY13244USA Department of Physics Columbia University538 W.120th StreetNew YorkNY10027 USA High Energy Physics Group Blackett LaboratoryImperial CollegePrince Consort RoadLondon SW7 2AZUK Jefferson Lab 12000 Jefferson Ave.Newport NewsVA 23606USA Department of Physics University of VirginiaPO Box 400714CharlottesvilleVA 22904USA Fermi National Accelerator Laboratory P.O.Box 500BataviaIL 60510USA Kavli Institute for Cosmological Physics University of ChicagoChicagoIL 60637-1433USA Department of Physics and Astronomy University of SussexFalmerBrighton BN1 9QHUK Department o

In the quark model, a ∧b0 is an isospin-0 udb state. The lowest ∧b0 ought to have JP = 1/2＋. None of I, J, or P have actually been measured.

关键词： HBC b~0 dsb ssb BOTTOM BARYONS

Synchronization of Fourier-Synthesized Optical Pulses to a Mode-Locked Optical Clock

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光学学报 2003年第S1期23卷 475-476页

作者： Masaharu Hyodo Kazi Sarwal Abedin Noriaki Onodera Masayoshi Watanabe Kansai Advanced Research Center Communications Research Laboratory 588-2 Iwaoka Nishi-ku Kobe 651-2492 JapanCommunications Research Laboratory 4-2-1 Nukui-kitamachi Koganei Tokyo 184-8795 JapanNational Defense Academy 1-10-20 Hashirimizu Yokosuka 239-8686 JapanKansai Advanced Research Center Communications Research Laboratory 588-2 Iwaoka Nishi-ku Kobe 651-2492 Japan

A Fourier-synthesized 40-GHz optical pulse train was successfully synchronized to an 8-GHz optical clock generated from a mode-locked fiber ring laser. The measured timing jitter of the synchronization was 0.43 ps.

关键词： of as be GHz FWM Synchronization of Fourier-Synthesized Optical Pulses to a Mode-Locked Optical Clock Figure were ssb from

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5G NR毫米波系统时频同步技术研究

5G NR毫米波系统时频同步技术研究

作者：刘宽电子科技大学

学位级别：硕士

毫米波频段技术已经应用于5G商用阶段,可以满足5G大规模通信系统更高速的数据传输需求,并且可以缓解日益严重的频带频谱紧张问题。在5G阶段,毫米波频段逐渐被纳入可考虑的通信频段之中,为了进一步提升通信质量,波束赋型技术也被大量地... 详细信息

毫米波频段技术已经应用于5G商用阶段,可以满足5G大规模通信系统更高速的数据传输需求,并且可以缓解日益严重的频带频谱紧张问题。在5G阶段,毫米波频段逐渐被纳入可考虑的通信频段之中,为了进一步提升通信质量,波束赋型技术也被大量地使用。通过多天线协同发射信号,可以控制信号功率在某一方向集中。通过集中朝向接收机方向的信号功率来对抗来自多径信道和毫米波在自由空间中高衰落的压力,也是在毫米波频段进行数据通信的前提。为了更好的利用波束赋型技术,5G NR规定了一种固定结构的信号,同步信号和PBCH块（简称ssb）,用来在用户初始接入阶段服务用户进行初始的波束扫描以及时频同步等操作。本文首先介绍了毫米波MIMO通信系统的背景意义以及研究现状,回顾在过去LTE时代MIMO技术在通信系统中的应用,并结合5G NR标准分析了5G时代毫米波MIMO技术与过去的不同。在此基础上,针对5G NR中广泛应用的波束扫描技术,给出了基于5G NR标准中波束扫描的初始接入方案,在方案中介绍了5G NR使用的同步信号结构以及时域发送模式,并且给出了较为广泛应用的毫米波信道模型。接下来从波束扫描可能带来的同步信号利用率低下的问题入手,引入了基于传统锁相环算法以及本文所提基于卡尔曼滤波器的时频精同步算法。通过仿真,比较了这两种算法在波束未覆盖用户带来的较低信噪比条件下的时频同步性能,验证了本文所提卡尔曼滤波时频精同步算法的优势。之后进行了时频同步系统的初步硬件实现,给出了4倍过采样条件下的时频同步电路图,搭配动态阈值模块,通过连续检测同步峰的形式锁定同步序列,并且具有一定的频偏纠正能力。最后分析了硬件电路实现时频精同步的后续改进方向。

关键词：毫米波 ssb 时频同步硬件实现