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spect-computed tomography in rats with TNBS-induced colitis: A first step toward functional imaging

World Journal of Gastroenterology 2017年第2期23卷 216-223页

作者： Rachel Marion-Letellier Pierre Bohn Romain Modzelewski Pierre Vera Moutaz Aziz Charlène Guérin Guillaume Savoye Céline Savoye-Collet INSERM Unit UMR1073 Rouen University and Rouen University Hospital QUANTIF LITIS EA 4108 Rouen University and Rouen University Hospital Service d’Anatomo-pathologie Rouen University Hospital Gastroenterology department Rouen University Hospital Radiology department Rouen University Hospital

AIMTo assess the feasibility of spect-computed tomography (CT) in rats with trinitrobenzene sulfonic acid (TNBS)-induced acute colitis and confront it with model inflammatory *** was induced in Sprague-Dawley rats by intrarectal injection of TNBS (n = 10) while controls received vehicle (n = 10). spect-CT with intravenous injection of 10 MBq of 67Ga-Citrate was performed at day 2. spect-CT criteria were colon wall thickness and maximal wall signal intensity. Laboratory parameters were assessed: colon weight:length ratio, colon cyclooxygenase-2 expression by western blot and histological inflammatory *** weight/length ratio, colon COX-2 expression and histological inflammatory score were significantly higher in the TNBS group than in the control group (P = 0.0296, P spectively). Pixel max tend to be higher in the TNBS group than in the control group but did not reach statistical significance (P = 0.0662). Maximal thickness is significantly increased in the TNBS group compared to the control group (P = 0.0016) while colon diameter is not (P = 0.1904). Maximal thickness and colon diameter were correlated to colon COX-2 expression (P = 0.0093, P = 0.009 respectively) while pixel max was not (P = 0.22). Maximal thickness was significantly increased when inflammation was histologically observed (P = 0.0043) while pixel max and colon diameter did not (P = 0.2452, P = 0.3541, respectively).CONCLUSIONspect-CT is feasible and easily distinguished control from colitic rats.

关键词： Crohn’ s disease Colitis Colitis imaging Cyclooxygenase-2 spect-computed tomography

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