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Inhibitory activity of polysaccharide extracts from three kinds of edible fungi on proliferation of human hepatoma smmc-7721 cell and mouse implanted S180 tumor

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World Journal of Gastroenterology 1999年第5期5卷 404-407页

作者： Jiang SM Xiao ZM Xu ZH Shandong Normal Univ Dept Biol Provincial Key Lab Anim Stress Jinan 250014 Shandong Prov Peoples R China Univ Heidelberg D-6900 Heidelberg Germany

AIM To determine the activities ofpolysaccharide extracts from Flammulina velutipes (Curt. ex Fr. ) Sing (FV), Lentinusedodes (LE) and Agaricus bisporus Sing (AB)on the proliferation of human hepatoma smmc-7721 cells in vitro and on mouse implanted S-180tumors in *** The polysaccharide extracts were isolated from the fruit bodies of FV, LE and AB by the methods of hot-water extraction, Sevag’sremoval of proteins, ethanol precipitation,trypsin digestion and ethanol fractionalprecipitation. Human hepatoma smmc-7721 cells were treated with 50 mg/L Polysaccharide extracts, and the mitosis index, mitochondria activity and cell proliferation were detected at different times in both control and experimental groups. The mice with S-180 implanted tumors were injected with the polysaccharide extracts at 24 mg/ kg body weight for 9 d and the tumorweight was measured on the 15th *** The mitosis index of hepatoma cells in vitro could be significantly decreased by treatment with the polysaccharide extracts fromthe three kinds of edible fungi (P smmc7721 cells treated with polysaccharide extracts were lower than those in control groups (P <0.005). The inhibition rates of polysaccharide extracts against implanted S-180 tumors in mice were 52.8%, 56.6% and 51 .9% respectivelycompared with that in c0ntrol ***0N The POIysaccharide extractsfrom the three kinds of edible fungi could inhibitnot only the Cultured malignant cells in vitfO butalso impIanted Sl80 tum0r i0 vivo.

关键词： polysaccharide, edible fungi liver neoplasm carcinoma, hepatocellular smmc7721, tumor cell, cultured implanted tumor, S-180 cell proliferation

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